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Dose-dependent effects of decaffeinated coffee on endothelial function in healthy subjects.
Eur J Clin Nutr 2009; 63(10):1200-5EJ

Abstract

BACKGROUND/OBJECTIVES

Coffee is known to contain antioxidant substances whose effects may be blunted because of caffeine that may unfavorably affect the cardiovascular system. This study was designed to investigate the acute dose-dependent effects of decaffeinated coffee (DC) on endothelial function measured by the brachial artery flow-mediated dilation (FMD).

SUBJECTS/METHODS

A total of 15 (8 men and 7 women) healthy nonobese subjects underwent a single-blind, crossover study. Subjects ingested one and two cups of decaffeinated Italian espresso coffee in random order at 5- to 7-day intervals.

RESULTS

In the hour following the ingestion of two cups of DC, FMD increased (mean+/-s.e.m.): 0 min, 7.4+/-0.7%; 30 min, 8.0+/-0.6%; 60 min, 10.8+/-0.8%; P<0.001) as compared to consumption of one cup of DC (0 min, 6.9+/-0.7%; 30 min, 8.4+/-1.2%; 60 min, 8.5+/-1.1%; 3 x 2 repeated-measures analysis of variance: P=0.037 for time x treatment effect). Blood pressure did not differ between groups, and basal heart rate was lower in the two-cup group at baseline and 60 min.

CONCLUSIONS

The present study demonstrated a significant acute favorable dose-dependent effect of decaffeinated espresso coffee on endothelial function. Further studies are needed to investigate the effects of chronic use of DC especially with respect to caffeinated coffee and in subjects with cardiovascular diseases.

Authors+Show Affiliations

Faculty of Medicine, Department of Internal Medicine, Cardiovascular and Kidney Diseases, University of Palermo, Palermo, Italy. silbus@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19550428

Citation

Buscemi, S, et al. "Dose-dependent Effects of Decaffeinated Coffee On Endothelial Function in Healthy Subjects." European Journal of Clinical Nutrition, vol. 63, no. 10, 2009, pp. 1200-5.
Buscemi S, Verga S, Batsis JA, et al. Dose-dependent effects of decaffeinated coffee on endothelial function in healthy subjects. Eur J Clin Nutr. 2009;63(10):1200-5.
Buscemi, S., Verga, S., Batsis, J. A., Tranchina, M. R., Belmonte, S., Mattina, A., ... Cerasola, G. (2009). Dose-dependent effects of decaffeinated coffee on endothelial function in healthy subjects. European Journal of Clinical Nutrition, 63(10), pp. 1200-5. doi:10.1038/ejcn.2009.51.
Buscemi S, et al. Dose-dependent Effects of Decaffeinated Coffee On Endothelial Function in Healthy Subjects. Eur J Clin Nutr. 2009;63(10):1200-5. PubMed PMID: 19550428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose-dependent effects of decaffeinated coffee on endothelial function in healthy subjects. AU - Buscemi,S, AU - Verga,S, AU - Batsis,J A, AU - Tranchina,M R, AU - Belmonte,S, AU - Mattina,A, AU - Re,A, AU - Rizzo,R, AU - Cerasola,G, Y1 - 2009/06/24/ PY - 2009/6/25/entrez PY - 2009/6/25/pubmed PY - 2010/1/5/medline SP - 1200 EP - 5 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 63 IS - 10 N2 - BACKGROUND/OBJECTIVES: Coffee is known to contain antioxidant substances whose effects may be blunted because of caffeine that may unfavorably affect the cardiovascular system. This study was designed to investigate the acute dose-dependent effects of decaffeinated coffee (DC) on endothelial function measured by the brachial artery flow-mediated dilation (FMD). SUBJECTS/METHODS: A total of 15 (8 men and 7 women) healthy nonobese subjects underwent a single-blind, crossover study. Subjects ingested one and two cups of decaffeinated Italian espresso coffee in random order at 5- to 7-day intervals. RESULTS: In the hour following the ingestion of two cups of DC, FMD increased (mean+/-s.e.m.): 0 min, 7.4+/-0.7%; 30 min, 8.0+/-0.6%; 60 min, 10.8+/-0.8%; P<0.001) as compared to consumption of one cup of DC (0 min, 6.9+/-0.7%; 30 min, 8.4+/-1.2%; 60 min, 8.5+/-1.1%; 3 x 2 repeated-measures analysis of variance: P=0.037 for time x treatment effect). Blood pressure did not differ between groups, and basal heart rate was lower in the two-cup group at baseline and 60 min. CONCLUSIONS: The present study demonstrated a significant acute favorable dose-dependent effect of decaffeinated espresso coffee on endothelial function. Further studies are needed to investigate the effects of chronic use of DC especially with respect to caffeinated coffee and in subjects with cardiovascular diseases. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/19550428/Dose_dependent_effects_of_decaffeinated_coffee_on_endothelial_function_in_healthy_subjects_ L2 - http://dx.doi.org/10.1038/ejcn.2009.51 DB - PRIME DP - Unbound Medicine ER -