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Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome.

Abstract

BACKGROUND

Polycystic ovary syndrome (PCOS) is the most common endocrine cause of hirsutism, acne and pattern alopecia, often characterised by ovulation disorders (usually manifested as oligo- or amenorrhea). In addition, 30-40% of women with PCOS have impaired glucose tolerance, and a defect in the insulin signalling pathway seems to be implicated in the pathogenesis of insulin resistance. For this reason, insulin-lowering medications represent novel approach in women with PCOS. The aim of this study was to evaluate the effects of myo-inositol (MYO), an isoform of inositol, belonging to the vitamin B complex, in the treatment of cutaneous disorders like hirsutism and acne.

METHODS

Fifty patients with PCOS were enrolled in the study. BMI, LH, FSH, insulin, HOMA index, androstenedione, testosterone, free testosterone, hirsutism and acne were evaluated at the baseline and after receiving MYO therapy for 6 months.

RESULTS

After 3 months of MYO administration, plasma LH, testosterone, free testosterone, insulin and HOMA index resulted significantly reduced; no significant changes were observed in plasma FSH and androstenedione levels. Both hirsutism and acne decreased after 6 months of therapy.

DISCUSSION

MYO administration is a simple and safe treatment that ameliorates the metabolic profile of patients with PCOS, reducing hirsutism and acne.

Links

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  • Authors+Show Affiliations

    ,

    Gynecological-Obstetric Department, IRCCS San Raffaele Hospital, Vita-Salute University, Milan, Italy. m.zacche@gmail.com

    , , , ,

    Source

    MeSH

    Acne Vulgaris
    Adult
    Drug Administration Schedule
    Female
    Hirsutism
    Homeostasis
    Humans
    Inositol
    Insulin
    Luteinizing Hormone
    Polycystic Ovary Syndrome
    Testosterone
    Treatment Outcome
    Vitamin B Complex
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19551544

    Citation

    Zacchè, Martino Maria, et al. "Efficacy of Myo-inositol in the Treatment of Cutaneous Disorders in Young Women With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 25, no. 8, 2009, pp. 508-13.
    Zacchè MM, Caputo L, Filippis S, et al. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25(8):508-13.
    Zacchè, M. M., Caputo, L., Filippis, S., Zacchè, G., Dindelli, M., & Ferrari, A. (2009). Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 25(8), pp. 508-13. doi:10.1080/09513590903015544.
    Zacchè MM, et al. Efficacy of Myo-inositol in the Treatment of Cutaneous Disorders in Young Women With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2009;25(8):508-13. PubMed PMID: 19551544.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. AU - Zacchè,Martino Maria, AU - Caputo,Luigi, AU - Filippis,Susanna, AU - Zacchè,Gabrio, AU - Dindelli,Moreno, AU - Ferrari,Augusto, PY - 2009/6/25/entrez PY - 2009/6/25/pubmed PY - 2010/1/28/medline SP - 508 EP - 13 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 25 IS - 8 N2 - BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrine cause of hirsutism, acne and pattern alopecia, often characterised by ovulation disorders (usually manifested as oligo- or amenorrhea). In addition, 30-40% of women with PCOS have impaired glucose tolerance, and a defect in the insulin signalling pathway seems to be implicated in the pathogenesis of insulin resistance. For this reason, insulin-lowering medications represent novel approach in women with PCOS. The aim of this study was to evaluate the effects of myo-inositol (MYO), an isoform of inositol, belonging to the vitamin B complex, in the treatment of cutaneous disorders like hirsutism and acne. METHODS: Fifty patients with PCOS were enrolled in the study. BMI, LH, FSH, insulin, HOMA index, androstenedione, testosterone, free testosterone, hirsutism and acne were evaluated at the baseline and after receiving MYO therapy for 6 months. RESULTS: After 3 months of MYO administration, plasma LH, testosterone, free testosterone, insulin and HOMA index resulted significantly reduced; no significant changes were observed in plasma FSH and androstenedione levels. Both hirsutism and acne decreased after 6 months of therapy. DISCUSSION: MYO administration is a simple and safe treatment that ameliorates the metabolic profile of patients with PCOS, reducing hirsutism and acne. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/19551544/Efficacy_of_myo_inositol_in_the_treatment_of_cutaneous_disorders_in_young__women_with_polycystic_ovary_syndrome_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590903015544 DB - PRIME DP - Unbound Medicine ER -