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Color Doppler imaging and ocular pulse amplitude in glaucomatous and healthy eyes.
Eur J Ophthalmol. 2009 Jul-Aug; 19(4):580-7.EJ

Abstract

PURPOSE

To determine factors influencing color Doppler imaging (CDI) measurements, to compare retrobulbar flow velocities between patients with glaucoma and healthy controls, and to describe the correlation between CDI and ocular pulse amplitude (OPA).

METHODS

Patients with normal tension (n=28) or primary open angle glaucoma (n=19) and healthy controls (n=22) underwent CDI and OPA measurements. Intraocular pressure, corneal thickness, blood pressure, and heart rate were also measured. Spearman correlations were used to explore relations among these variables. A regression model for repeated measures was applied to compare between diagnostic groups the flow velocity indices in the retrobulbar vessels.

RESULTS

Retrobulbar diastolic blood flow velocities correlated with diastolic blood pressure and perfusion pressure (range of Spearman rho [rho] coefficients=0.25-0.28; p=0.044-0.013 for the different vessels). Corneal thickness showed a positive correlation with systolic and diastolic flow velocities in the central retinal artery (rho=0.29 and 0.31; p=0.017 and 0.011 for peak systolic and end diastolic velocity, respectively). Systolic and diastolic blood flow velocities were reduced in the retrobulbar vessels of patients with normal tension glaucoma (P=0.0004) as well as primary open angle glaucoma (P=0.003) compared to healthy controls. A correlation was found between OPA and the resistive index in the retrobulbar vessels of the healthy controls (range rho=0.42-0.53; p=0.059-0.014).

CONCLUSIONS

Retrobulbar blood flow velocities are reduced in patients with primary open angle glaucoma and normal tension glaucoma. Blood pressure and corneal thickness may influence CDI measurements. OPA correlates with the resistive index in CDI.

Authors+Show Affiliations

Department of Ophthalmology, University Hospitals Leuven, Campus St Raphaël, Leuven - Belgium. ingeborg.stalmans@uzleuven.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19551672

Citation

Stalmans, Ingeborg, et al. "Color Doppler Imaging and Ocular Pulse Amplitude in Glaucomatous and Healthy Eyes." European Journal of Ophthalmology, vol. 19, no. 4, 2009, pp. 580-7.
Stalmans I, Harris A, Fieuws S, et al. Color Doppler imaging and ocular pulse amplitude in glaucomatous and healthy eyes. Eur J Ophthalmol. 2009;19(4):580-7.
Stalmans, I., Harris, A., Fieuws, S., Zeyen, T., Vanbellinghen, V., McCranor, L., & Siesky, B. (2009). Color Doppler imaging and ocular pulse amplitude in glaucomatous and healthy eyes. European Journal of Ophthalmology, 19(4), 580-7.
Stalmans I, et al. Color Doppler Imaging and Ocular Pulse Amplitude in Glaucomatous and Healthy Eyes. Eur J Ophthalmol. 2009 Jul-Aug;19(4):580-7. PubMed PMID: 19551672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Color Doppler imaging and ocular pulse amplitude in glaucomatous and healthy eyes. AU - Stalmans,Ingeborg, AU - Harris,Alon, AU - Fieuws,Steffen, AU - Zeyen,Thierry, AU - Vanbellinghen,Veerle, AU - McCranor,Lynne, AU - Siesky,Brent, PY - 2009/6/25/entrez PY - 2009/6/25/pubmed PY - 2009/12/16/medline SP - 580 EP - 7 JF - European journal of ophthalmology JO - Eur J Ophthalmol VL - 19 IS - 4 N2 - PURPOSE: To determine factors influencing color Doppler imaging (CDI) measurements, to compare retrobulbar flow velocities between patients with glaucoma and healthy controls, and to describe the correlation between CDI and ocular pulse amplitude (OPA). METHODS: Patients with normal tension (n=28) or primary open angle glaucoma (n=19) and healthy controls (n=22) underwent CDI and OPA measurements. Intraocular pressure, corneal thickness, blood pressure, and heart rate were also measured. Spearman correlations were used to explore relations among these variables. A regression model for repeated measures was applied to compare between diagnostic groups the flow velocity indices in the retrobulbar vessels. RESULTS: Retrobulbar diastolic blood flow velocities correlated with diastolic blood pressure and perfusion pressure (range of Spearman rho [rho] coefficients=0.25-0.28; p=0.044-0.013 for the different vessels). Corneal thickness showed a positive correlation with systolic and diastolic flow velocities in the central retinal artery (rho=0.29 and 0.31; p=0.017 and 0.011 for peak systolic and end diastolic velocity, respectively). Systolic and diastolic blood flow velocities were reduced in the retrobulbar vessels of patients with normal tension glaucoma (P=0.0004) as well as primary open angle glaucoma (P=0.003) compared to healthy controls. A correlation was found between OPA and the resistive index in the retrobulbar vessels of the healthy controls (range rho=0.42-0.53; p=0.059-0.014). CONCLUSIONS: Retrobulbar blood flow velocities are reduced in patients with primary open angle glaucoma and normal tension glaucoma. Blood pressure and corneal thickness may influence CDI measurements. OPA correlates with the resistive index in CDI. SN - 1120-6721 UR - https://www.unboundmedicine.com/medline/citation/19551672/Color_Doppler_imaging_and_ocular_pulse_amplitude_in_glaucomatous_and_healthy_eyes_ L2 - https://journals.sagepub.com/doi/10.1177/112067210901900410?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -