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Properties of theophylline tablets dry powder coated with Eudragit((R)) E PO and Eudragit((R)) L 100-55.
Pharm Dev Technol. 2009 Apr 21 [Online ahead of print]PD

Abstract

The aim of the present study was to investigate the influence of Eudragit((R)) E PO on the drug release mechanism of Eudragit((R)) L 100-55 film coatings applied to theophylline tablets by a dry powder coating technique. The process was entirely liquid-free. Calculation of the Flory-Huggins interaction parameter based on solubility parameters suggested immiscibility of the two copolymers. MDSC thermograms were characterized by two glass transitions for the investigated Eudragit((R)) E PO/Eudragit((R)) L 100-55 ratios and confirmed incomplete miscibility of the copolymers at processing conditions. FT-IR analysis was employed to study binding interactions of the polymers. Due to the higher affinity of the plasticizer, triethyl citrate, for Eudragit((R)) E PO compared to Eudragit((R)) L 100-55, redistribution of the plasticizer was observed during the curing phase of the process. Plasticizer migration also affected the initial phase of drug release from powder-coated theophylline tablets that were stored for four weeks. Drug release from powder-coated tablets was dependent on the polymer blend ratio, coating thickness, and the pH of the dissolution medium. A broad range of pH dependent theophylline release profiles were obtained as a function of the polymer blend ratio. The particle size of the coating powder influenced the microstructure of the film coating.

Authors+Show Affiliations

College of Pharmacy, The University of Texas at Austin, Austin, 78712 USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19552552

Citation

Sauer, Dorothea, and James McGinity. "Properties of Theophylline Tablets Dry Powder Coated With Eudragit((R)) E PO and Eudragit((R)) L 100-55." Pharmaceutical Development and Technology, 2009.
Sauer D, McGinity J. Properties of theophylline tablets dry powder coated with Eudragit((R)) E PO and Eudragit((R)) L 100-55. Pharm Dev Technol. 2009.
Sauer, D., & McGinity, J. (2009). Properties of theophylline tablets dry powder coated with Eudragit((R)) E PO and Eudragit((R)) L 100-55. Pharmaceutical Development and Technology.
Sauer D, McGinity J. Properties of Theophylline Tablets Dry Powder Coated With Eudragit((R)) E PO and Eudragit((R)) L 100-55. Pharm Dev Technol. 2009 Apr 21;. PubMed PMID: 19552552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Properties of theophylline tablets dry powder coated with Eudragit((R)) E PO and Eudragit((R)) L 100-55. AU - Sauer,Dorothea, AU - McGinity,James, Y1 - 2009/04/21/ PY - 2009/6/26/entrez PY - 2009/6/26/pubmed PY - 2009/6/26/medline SP - EP - JF - Pharmaceutical development and technology JO - Pharm Dev Technol N2 - The aim of the present study was to investigate the influence of Eudragit((R)) E PO on the drug release mechanism of Eudragit((R)) L 100-55 film coatings applied to theophylline tablets by a dry powder coating technique. The process was entirely liquid-free. Calculation of the Flory-Huggins interaction parameter based on solubility parameters suggested immiscibility of the two copolymers. MDSC thermograms were characterized by two glass transitions for the investigated Eudragit((R)) E PO/Eudragit((R)) L 100-55 ratios and confirmed incomplete miscibility of the copolymers at processing conditions. FT-IR analysis was employed to study binding interactions of the polymers. Due to the higher affinity of the plasticizer, triethyl citrate, for Eudragit((R)) E PO compared to Eudragit((R)) L 100-55, redistribution of the plasticizer was observed during the curing phase of the process. Plasticizer migration also affected the initial phase of drug release from powder-coated theophylline tablets that were stored for four weeks. Drug release from powder-coated tablets was dependent on the polymer blend ratio, coating thickness, and the pH of the dissolution medium. A broad range of pH dependent theophylline release profiles were obtained as a function of the polymer blend ratio. The particle size of the coating powder influenced the microstructure of the film coating. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/19552552/Properties_of_theophylline_tablets_dry_powder_coated_with_Eudragit__R___E_PO_and_Eudragit__R___L_100_55_ L2 - https://www.tandfonline.com/doi/full/10.1080/10837450902882369 DB - PRIME DP - Unbound Medicine ER -
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