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A global study of pathogens and host risk factors associated with infectious gastrointestinal disease in returned international travellers.
J Infect. 2009 Jul; 59(1):19-27.JI

Abstract

OBJECTIVES

Infectious gastrointestinal disease (IGD) is a significant cause of morbidity in returned international travellers. This study aims to elucidate host and travel characteristics associated with IGD presentation, and describe the broad spectrum of aetiological pathogens responsible by geographic region of acquisition and reason for travel.

METHODS

We analyzed demographic, clinical and microbiological data recorded for ill, returned international travellers presenting to GeoSentinel Surveillance Network sites globally during the period September 1996-December 2005.

RESULTS

A total of 25,867 returned travellers were analyzed, of whom 7442 (29%) patients had a total of 8273 IGD diagnoses. Multivariate analysis demonstrated that IGD presentation was associated significantly with female sex (OR: 1.11; p=0.001); younger age group; attending a pre-travel medical appointment (OR: 1.28; p<0.0001); and travelling for the reason of tourism. Travelling for longer periods (>28 days) was associated with lower risk (OR: 0.93; p=0.04). Of the 2902 clinically significant pathogens isolated, 65% were parasitic, 31% bacterial and 3% viral. Presentation of IGD by specific pathogen varied markedly dependent on geographic region of recent travel, and reason for travel.

CONCLUSIONS

Host characteristics, region of travel and category of traveller, significantly impact on the relative likelihood of presenting with a broad range of pathogen-specific IGD.

Authors+Show Affiliations

National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19552961

Citation

Swaminathan, Ashwin, et al. "A Global Study of Pathogens and Host Risk Factors Associated With Infectious Gastrointestinal Disease in Returned International Travellers." The Journal of Infection, vol. 59, no. 1, 2009, pp. 19-27.
Swaminathan A, Torresi J, Schlagenhauf P, et al. A global study of pathogens and host risk factors associated with infectious gastrointestinal disease in returned international travellers. J Infect. 2009;59(1):19-27.
Swaminathan, A., Torresi, J., Schlagenhauf, P., Thursky, K., Wilder-Smith, A., Connor, B. A., Schwartz, E., Vonsonnenberg, F., Keystone, J., & O'Brien, D. P. (2009). A global study of pathogens and host risk factors associated with infectious gastrointestinal disease in returned international travellers. The Journal of Infection, 59(1), 19-27. https://doi.org/10.1016/j.jinf.2009.05.008
Swaminathan A, et al. A Global Study of Pathogens and Host Risk Factors Associated With Infectious Gastrointestinal Disease in Returned International Travellers. J Infect. 2009;59(1):19-27. PubMed PMID: 19552961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A global study of pathogens and host risk factors associated with infectious gastrointestinal disease in returned international travellers. AU - Swaminathan,Ashwin, AU - Torresi,Joseph, AU - Schlagenhauf,Patricia, AU - Thursky,Karin, AU - Wilder-Smith,Annelies, AU - Connor,Bradley A, AU - Schwartz,Eli, AU - Vonsonnenberg,Frank, AU - Keystone,Jay, AU - O'Brien,Daniel P, AU - ,, Y1 - 2009/05/31/ PY - 2008/10/10/received PY - 2009/04/27/revised PY - 2009/05/13/accepted PY - 2009/6/26/entrez PY - 2009/6/26/pubmed PY - 2009/8/29/medline SP - 19 EP - 27 JF - The Journal of infection JO - J. Infect. VL - 59 IS - 1 N2 - OBJECTIVES: Infectious gastrointestinal disease (IGD) is a significant cause of morbidity in returned international travellers. This study aims to elucidate host and travel characteristics associated with IGD presentation, and describe the broad spectrum of aetiological pathogens responsible by geographic region of acquisition and reason for travel. METHODS: We analyzed demographic, clinical and microbiological data recorded for ill, returned international travellers presenting to GeoSentinel Surveillance Network sites globally during the period September 1996-December 2005. RESULTS: A total of 25,867 returned travellers were analyzed, of whom 7442 (29%) patients had a total of 8273 IGD diagnoses. Multivariate analysis demonstrated that IGD presentation was associated significantly with female sex (OR: 1.11; p=0.001); younger age group; attending a pre-travel medical appointment (OR: 1.28; p<0.0001); and travelling for the reason of tourism. Travelling for longer periods (>28 days) was associated with lower risk (OR: 0.93; p=0.04). Of the 2902 clinically significant pathogens isolated, 65% were parasitic, 31% bacterial and 3% viral. Presentation of IGD by specific pathogen varied markedly dependent on geographic region of recent travel, and reason for travel. CONCLUSIONS: Host characteristics, region of travel and category of traveller, significantly impact on the relative likelihood of presenting with a broad range of pathogen-specific IGD. SN - 1532-2742 UR - https://www.unboundmedicine.com/medline/citation/19552961/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-4453(09)00159-5 DB - PRIME DP - Unbound Medicine ER -