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Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET.

Abstract

INTRODUCTION

previous studies have suggested that smoking, living alone and having a high body mass index may increase risk of developing dementia whereas a normal body mass index, having received education and moderate alcohol consumption may decrease risk. Dementia risk also increases with age and is thought to be higher in hypertensives.

METHOD

we used data collected in the Hypertension in the Very Elderly Trial (HYVET), and cognitive function was assessed using the Mini-Mental State Examination (MMSE) at baseline and annually. Participants with a fall in MMSE to <24 or with a fall of 3 points in any 1 year were investigated further. The association of baseline sociodemographic, medical and lifestyle factors with incident dementia or decline in MMSE scores was assessed by regression models.

RESULTS

incident dementia occurred in 263 of 3,336 participants over a mean follow-up of 2 years. In multivariate analyses, being underweight, BMI < 18.5 (HR 1.90, 95% CI 1.06-3.39) or obese, BMI >30 (HR 1.84, 95% CI 1.24-2.72), increased risk of incident dementia as did piracetam use (HR 2.72, 95% CI 1.60-4.63). Receiving formal education was associated with a reduced risk (HR 0.59, 95% CI 0.45-0.78). There was no association with smoking, alcohol and gender. Similar results were found when examining mean annual change in the MMSE score.

DISCUSSION

our results for BMI and education agree with those from other studies. The increased risk associated with piracetam may reflect awareness of memory problems before any diagnosis of dementia has been made. Trial participants may be healthier than the general population and further studies in the general population are required.

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  • Authors+Show Affiliations

    ,

    Care of the Elderly, Faculty of Medicine, Imperial College London, W12 0NN, UK. r.peters@imperial.ac.uk

    , , , , , , , , ,

    Source

    Age and ageing 38:5 2009 Sep pg 521-7

    MeSH

    Aged, 80 and over
    Aging
    Alcohol Drinking
    Antihypertensive Agents
    Cognition Disorders
    Dementia
    Educational Status
    Female
    Follow-Up Studies
    Humans
    Hypertension
    Incidence
    Life Style
    Male
    Nootropic Agents
    Piracetam
    Predictive Value of Tests
    Randomized Controlled Trials as Topic
    Regression Analysis
    Risk Factors
    Smoking
    Socioeconomic Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19553357

    Citation

    Peters, Ruth, et al. "Sociodemographic and Lifestyle Risk Factors for Incident Dementia and Cognitive Decline in the HYVET." Age and Ageing, vol. 38, no. 5, 2009, pp. 521-7.
    Peters R, Beckett N, Geneva M, et al. Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET. Age Ageing. 2009;38(5):521-7.
    Peters, R., Beckett, N., Geneva, M., Tzekova, M., Lu, F. H., Poulter, R., ... Bulpitt, C. (2009). Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET. Age and Ageing, 38(5), pp. 521-7. doi:10.1093/ageing/afp094.
    Peters R, et al. Sociodemographic and Lifestyle Risk Factors for Incident Dementia and Cognitive Decline in the HYVET. Age Ageing. 2009;38(5):521-7. PubMed PMID: 19553357.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET. AU - Peters,Ruth, AU - Beckett,Nigel, AU - Geneva,Mariela, AU - Tzekova,Maria, AU - Lu,Fang Hong, AU - Poulter,Ruth, AU - Gainsborough,Nicola, AU - Williams,Brian, AU - de Vernejoul,Marie-Christine, AU - Fletcher,Astrid, AU - Bulpitt,Christopher, Y1 - 2009/06/24/ PY - 2009/6/26/entrez PY - 2009/6/26/pubmed PY - 2009/11/6/medline SP - 521 EP - 7 JF - Age and ageing JO - Age Ageing VL - 38 IS - 5 N2 - INTRODUCTION: previous studies have suggested that smoking, living alone and having a high body mass index may increase risk of developing dementia whereas a normal body mass index, having received education and moderate alcohol consumption may decrease risk. Dementia risk also increases with age and is thought to be higher in hypertensives. METHOD: we used data collected in the Hypertension in the Very Elderly Trial (HYVET), and cognitive function was assessed using the Mini-Mental State Examination (MMSE) at baseline and annually. Participants with a fall in MMSE to <24 or with a fall of 3 points in any 1 year were investigated further. The association of baseline sociodemographic, medical and lifestyle factors with incident dementia or decline in MMSE scores was assessed by regression models. RESULTS: incident dementia occurred in 263 of 3,336 participants over a mean follow-up of 2 years. In multivariate analyses, being underweight, BMI < 18.5 (HR 1.90, 95% CI 1.06-3.39) or obese, BMI >30 (HR 1.84, 95% CI 1.24-2.72), increased risk of incident dementia as did piracetam use (HR 2.72, 95% CI 1.60-4.63). Receiving formal education was associated with a reduced risk (HR 0.59, 95% CI 0.45-0.78). There was no association with smoking, alcohol and gender. Similar results were found when examining mean annual change in the MMSE score. DISCUSSION: our results for BMI and education agree with those from other studies. The increased risk associated with piracetam may reflect awareness of memory problems before any diagnosis of dementia has been made. Trial participants may be healthier than the general population and further studies in the general population are required. SN - 1468-2834 UR - https://www.unboundmedicine.com/medline/citation/19553357/Sociodemographic_and_lifestyle_risk_factors_for_incident_dementia_and_cognitive_decline_in_the_HYVET_ L2 - https://academic.oup.com/ageing/article-lookup/doi/10.1093/ageing/afp094 DB - PRIME DP - Unbound Medicine ER -