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Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET.
Age Ageing. 2009 Sep; 38(5):521-7.AA

Abstract

INTRODUCTION

previous studies have suggested that smoking, living alone and having a high body mass index may increase risk of developing dementia whereas a normal body mass index, having received education and moderate alcohol consumption may decrease risk. Dementia risk also increases with age and is thought to be higher in hypertensives.

METHOD

we used data collected in the Hypertension in the Very Elderly Trial (HYVET), and cognitive function was assessed using the Mini-Mental State Examination (MMSE) at baseline and annually. Participants with a fall in MMSE to <24 or with a fall of 3 points in any 1 year were investigated further. The association of baseline sociodemographic, medical and lifestyle factors with incident dementia or decline in MMSE scores was assessed by regression models.

RESULTS

incident dementia occurred in 263 of 3,336 participants over a mean follow-up of 2 years. In multivariate analyses, being underweight, BMI < 18.5 (HR 1.90, 95% CI 1.06-3.39) or obese, BMI >30 (HR 1.84, 95% CI 1.24-2.72), increased risk of incident dementia as did piracetam use (HR 2.72, 95% CI 1.60-4.63). Receiving formal education was associated with a reduced risk (HR 0.59, 95% CI 0.45-0.78). There was no association with smoking, alcohol and gender. Similar results were found when examining mean annual change in the MMSE score.

DISCUSSION

our results for BMI and education agree with those from other studies. The increased risk associated with piracetam may reflect awareness of memory problems before any diagnosis of dementia has been made. Trial participants may be healthier than the general population and further studies in the general population are required.

Authors+Show Affiliations

Care of the Elderly, Faculty of Medicine, Imperial College London, W12 0NN, UK. r.peters@imperial.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19553357

Citation

Peters, Ruth, et al. "Sociodemographic and Lifestyle Risk Factors for Incident Dementia and Cognitive Decline in the HYVET." Age and Ageing, vol. 38, no. 5, 2009, pp. 521-7.
Peters R, Beckett N, Geneva M, et al. Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET. Age Ageing. 2009;38(5):521-7.
Peters, R., Beckett, N., Geneva, M., Tzekova, M., Lu, F. H., Poulter, R., Gainsborough, N., Williams, B., de Vernejoul, M. C., Fletcher, A., & Bulpitt, C. (2009). Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET. Age and Ageing, 38(5), 521-7. https://doi.org/10.1093/ageing/afp094
Peters R, et al. Sociodemographic and Lifestyle Risk Factors for Incident Dementia and Cognitive Decline in the HYVET. Age Ageing. 2009;38(5):521-7. PubMed PMID: 19553357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sociodemographic and lifestyle risk factors for incident dementia and cognitive decline in the HYVET. AU - Peters,Ruth, AU - Beckett,Nigel, AU - Geneva,Mariela, AU - Tzekova,Maria, AU - Lu,Fang Hong, AU - Poulter,Ruth, AU - Gainsborough,Nicola, AU - Williams,Brian, AU - de Vernejoul,Marie-Christine, AU - Fletcher,Astrid, AU - Bulpitt,Christopher, Y1 - 2009/06/24/ PY - 2009/6/26/entrez PY - 2009/6/26/pubmed PY - 2009/11/6/medline SP - 521 EP - 7 JF - Age and ageing JO - Age Ageing VL - 38 IS - 5 N2 - INTRODUCTION: previous studies have suggested that smoking, living alone and having a high body mass index may increase risk of developing dementia whereas a normal body mass index, having received education and moderate alcohol consumption may decrease risk. Dementia risk also increases with age and is thought to be higher in hypertensives. METHOD: we used data collected in the Hypertension in the Very Elderly Trial (HYVET), and cognitive function was assessed using the Mini-Mental State Examination (MMSE) at baseline and annually. Participants with a fall in MMSE to <24 or with a fall of 3 points in any 1 year were investigated further. The association of baseline sociodemographic, medical and lifestyle factors with incident dementia or decline in MMSE scores was assessed by regression models. RESULTS: incident dementia occurred in 263 of 3,336 participants over a mean follow-up of 2 years. In multivariate analyses, being underweight, BMI < 18.5 (HR 1.90, 95% CI 1.06-3.39) or obese, BMI >30 (HR 1.84, 95% CI 1.24-2.72), increased risk of incident dementia as did piracetam use (HR 2.72, 95% CI 1.60-4.63). Receiving formal education was associated with a reduced risk (HR 0.59, 95% CI 0.45-0.78). There was no association with smoking, alcohol and gender. Similar results were found when examining mean annual change in the MMSE score. DISCUSSION: our results for BMI and education agree with those from other studies. The increased risk associated with piracetam may reflect awareness of memory problems before any diagnosis of dementia has been made. Trial participants may be healthier than the general population and further studies in the general population are required. SN - 1468-2834 UR - https://www.unboundmedicine.com/medline/citation/19553357/Sociodemographic_and_lifestyle_risk_factors_for_incident_dementia_and_cognitive_decline_in_the_HYVET_ L2 - https://academic.oup.com/ageing/article-lookup/doi/10.1093/ageing/afp094 DB - PRIME DP - Unbound Medicine ER -