Tags

Type your tag names separated by a space and hit enter

Mitochondrial dysfunction and Parkinson's disease genes: insights from Drosophila.
Dis Model Mech. 2009 Jul-Aug; 2(7-8):336-40.DM

Abstract

Parkinson's disease (PD), one of the most common neurodegenerative disorders worldwide, currently lacks a cure. Although most PD cases occur sporadically, studies from rare genetic mutations give significant insights into addressing the pathological mechanism of not only familial PD, but also sporadic PD. Recent PD research focuses on generating genetic mutant animal models that recapitulate the features of human PD patients. Significant advances in PD research have resulted from studying Drosophila mutants of several identified PD-associated genes because they show strikingly visible phenotypes. In particular, previous studies with the Drosophila mutants parkin and PINK1, which are two common causative genes among PD familial forms, have suggested strongly that mitochondrial dysfunction is the prominent cause for the PD pathogenesis and that these two PD genes are in a common pathway, with Parkin downstream of PINK1. Recent genetic studies have revealed that the PINK1-Parkin pathway is involved in regulating the mitochondrial remodeling process. In addition, PINK1 was recently found to regulate the localization of Parkin through direct phosphorylation. Here, we briefly review these new and exciting findings in Drosophila PD models and discuss how using these models can further advance PD studies.

Authors+Show Affiliations

National Creative Research Initiatives Center for Cell Growth Regulation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Kusong-Dong, Yusong-Gu, Taejon 305-701, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19553694

Citation

Park, Jeehye, et al. "Mitochondrial Dysfunction and Parkinson's Disease Genes: Insights From Drosophila." Disease Models & Mechanisms, vol. 2, no. 7-8, 2009, pp. 336-40.
Park J, Kim Y, Chung J. Mitochondrial dysfunction and Parkinson's disease genes: insights from Drosophila. Dis Model Mech. 2009;2(7-8):336-40.
Park, J., Kim, Y., & Chung, J. (2009). Mitochondrial dysfunction and Parkinson's disease genes: insights from Drosophila. Disease Models & Mechanisms, 2(7-8), 336-40. https://doi.org/10.1242/dmm.003178
Park J, Kim Y, Chung J. Mitochondrial Dysfunction and Parkinson's Disease Genes: Insights From Drosophila. Dis Model Mech. 2009 Jul-Aug;2(7-8):336-40. PubMed PMID: 19553694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial dysfunction and Parkinson's disease genes: insights from Drosophila. AU - Park,Jeehye, AU - Kim,Yongsung, AU - Chung,Jongkyeong, PY - 2009/6/26/entrez PY - 2009/6/26/pubmed PY - 2009/10/9/medline SP - 336 EP - 40 JF - Disease models & mechanisms JO - Dis Model Mech VL - 2 IS - 7-8 N2 - Parkinson's disease (PD), one of the most common neurodegenerative disorders worldwide, currently lacks a cure. Although most PD cases occur sporadically, studies from rare genetic mutations give significant insights into addressing the pathological mechanism of not only familial PD, but also sporadic PD. Recent PD research focuses on generating genetic mutant animal models that recapitulate the features of human PD patients. Significant advances in PD research have resulted from studying Drosophila mutants of several identified PD-associated genes because they show strikingly visible phenotypes. In particular, previous studies with the Drosophila mutants parkin and PINK1, which are two common causative genes among PD familial forms, have suggested strongly that mitochondrial dysfunction is the prominent cause for the PD pathogenesis and that these two PD genes are in a common pathway, with Parkin downstream of PINK1. Recent genetic studies have revealed that the PINK1-Parkin pathway is involved in regulating the mitochondrial remodeling process. In addition, PINK1 was recently found to regulate the localization of Parkin through direct phosphorylation. Here, we briefly review these new and exciting findings in Drosophila PD models and discuss how using these models can further advance PD studies. SN - 1754-8411 UR - https://www.unboundmedicine.com/medline/citation/19553694/Mitochondrial_dysfunction_and_Parkinson's_disease_genes:_insights_from_Drosophila_ L2 - http://dmm.biologists.org/cgi/pmidlookup?view=long&pmid=19553694 DB - PRIME DP - Unbound Medicine ER -