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Interleukin-6 and tumor necrosis factor-alpha as biochemical markers of heart failure: a head-to-head clinical comparison with B-type natriuretic peptide.
J Cardiovasc Med (Hagerstown). 2009 Oct; 10(10):758-64.JC

Abstract

BACKGROUND

The reliability of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) as biochemical markers of heart failure in comparison to B-type natriuretic peptide (BNP) has not been investigated in depth.

AIM

To compare the correlations between IL-6, TNF, BNP plasma concentrations and some clinical and instrumental variables and their prognostic value in heart failure patients.

METHODS

In 79 patients with heart failure, the correlations between IL-6, TNF and BNP plasma concentrations and a series of 18 variables were studied. Outcome events were death from any cause and combined death and heart transplantation.

RESULTS

At univariate analysis, BNP and IL-6 plasma concentrations correlated with each other (r = 0.4828; P < 0.0001), with New York Heart Association class, fluid retention, left ventricular ejection fraction, mean right atrial pressure, mean pulmonary pressure and cardiac index. All these correlations were stronger with BNP. TNF plasma concentration correlated only with New York Heart Association class and left ventricular ejection fraction.During follow-up, 1-32 months, 14 patients died and nine underwent heart transplantation. At univariate analysis, both BNP and IL-6 plasma concentrations were predictors of death and heart transplantation, but only BNP was a predictor of death; however, only creatinine plasma level was an independent predictor of prognosis.

CONCLUSION

IL-6 and TNF are less reliable biochemical markers than BNP in heart failure patients.

Authors+Show Affiliations

Department of Cardiology, University of Padua, Padua, Italy. giovanni.boffa@unipdNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19553828

Citation

Boffa, Giovanni M., et al. "Interleukin-6 and Tumor Necrosis Factor-alpha as Biochemical Markers of Heart Failure: a Head-to-head Clinical Comparison With B-type Natriuretic Peptide." Journal of Cardiovascular Medicine (Hagerstown, Md.), vol. 10, no. 10, 2009, pp. 758-64.
Boffa GM, Zaninotto M, Sartor R, et al. Interleukin-6 and tumor necrosis factor-alpha as biochemical markers of heart failure: a head-to-head clinical comparison with B-type natriuretic peptide. J Cardiovasc Med (Hagerstown). 2009;10(10):758-64.
Boffa, G. M., Zaninotto, M., Sartor, R., Mion, M., Berton, A., Pasqualetto, C., Razzolini, R., & Plebani, M. (2009). Interleukin-6 and tumor necrosis factor-alpha as biochemical markers of heart failure: a head-to-head clinical comparison with B-type natriuretic peptide. Journal of Cardiovascular Medicine (Hagerstown, Md.), 10(10), 758-64. https://doi.org/10.2459/JCM.0b013e32832ce8e2
Boffa GM, et al. Interleukin-6 and Tumor Necrosis Factor-alpha as Biochemical Markers of Heart Failure: a Head-to-head Clinical Comparison With B-type Natriuretic Peptide. J Cardiovasc Med (Hagerstown). 2009;10(10):758-64. PubMed PMID: 19553828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interleukin-6 and tumor necrosis factor-alpha as biochemical markers of heart failure: a head-to-head clinical comparison with B-type natriuretic peptide. AU - Boffa,Giovanni M, AU - Zaninotto,Martina, AU - Sartor,Riccardo, AU - Mion,Monica, AU - Berton,Alessandra, AU - Pasqualetto,Cristina, AU - Razzolini,Renato, AU - Plebani,Mario, PY - 2009/6/26/entrez PY - 2009/6/26/pubmed PY - 2009/10/16/medline SP - 758 EP - 64 JF - Journal of cardiovascular medicine (Hagerstown, Md.) JO - J Cardiovasc Med (Hagerstown) VL - 10 IS - 10 N2 - BACKGROUND: The reliability of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) as biochemical markers of heart failure in comparison to B-type natriuretic peptide (BNP) has not been investigated in depth. AIM: To compare the correlations between IL-6, TNF, BNP plasma concentrations and some clinical and instrumental variables and their prognostic value in heart failure patients. METHODS: In 79 patients with heart failure, the correlations between IL-6, TNF and BNP plasma concentrations and a series of 18 variables were studied. Outcome events were death from any cause and combined death and heart transplantation. RESULTS: At univariate analysis, BNP and IL-6 plasma concentrations correlated with each other (r = 0.4828; P < 0.0001), with New York Heart Association class, fluid retention, left ventricular ejection fraction, mean right atrial pressure, mean pulmonary pressure and cardiac index. All these correlations were stronger with BNP. TNF plasma concentration correlated only with New York Heart Association class and left ventricular ejection fraction.During follow-up, 1-32 months, 14 patients died and nine underwent heart transplantation. At univariate analysis, both BNP and IL-6 plasma concentrations were predictors of death and heart transplantation, but only BNP was a predictor of death; however, only creatinine plasma level was an independent predictor of prognosis. CONCLUSION: IL-6 and TNF are less reliable biochemical markers than BNP in heart failure patients. SN - 1558-2027 UR - https://www.unboundmedicine.com/medline/citation/19553828/Interleukin_6_and_tumor_necrosis_factor_alpha_as_biochemical_markers_of_heart_failure:_a_head_to_head_clinical_comparison_with_B_type_natriuretic_peptide_ L2 - https://doi.org/10.2459/JCM.0b013e32832ce8e2 DB - PRIME DP - Unbound Medicine ER -