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Preparation and characterization of spray-dried mucoadhesive microspheres of aceclofenac.
Drug Dev Ind Pharm. 2009 Oct; 35(10):1155-66.DD

Abstract

OBJECTIVE

Microencapsulation of the anti-inflammatory drug aceclofenac (ACE) was investigated as a means of controlling drug release and minimizing or eliminating local side effects.

METHOD

Microspheres were prepared by a spray-drying technique using solutions of ACE and three polymers, namely, carbopol, chitosan, and polycarbophil, in different weight ratios.

RESULTS

The spray-dried mucoadhesive microspheres were characterized in terms of shape (scanning electron microscope), size (6.60-8.40 mum), production yield (34.10-55.62%), and encapsulation efficiency (58.14-90.57%). In vitro release studies were performed in phosphate buffer (pH 6.8) up to 10 hours. The spray-drying process of solutions of ACE with polymeric blends can give prolonged drug release. The in vitro release data were well fit into Higuchi and Korsmeyer-Peppas model and followed Fickian diffusion mechanism. In vivo data showed that the administration of ACE in polymeric microspheres prevented the gastric side effects.

CONCLUSION

The formulations here described can be proposed for the oral administration of nonsteroidal anti-inflammatory drugs with minimal side effects on gastric mucosa.

Authors+Show Affiliations

Indukaka Ipcowala College of Pharmacy, Beyond GIDC Phase IV, Vithal Udyognagar, New Vallabh Vidyanagar, Anand, Gujarat, India. cnagda_rx@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19555239

Citation

Nagda, Chirag, et al. "Preparation and Characterization of Spray-dried Mucoadhesive Microspheres of Aceclofenac." Drug Development and Industrial Pharmacy, vol. 35, no. 10, 2009, pp. 1155-66.
Nagda C, Chotai NP, Patel U, et al. Preparation and characterization of spray-dried mucoadhesive microspheres of aceclofenac. Drug Dev Ind Pharm. 2009;35(10):1155-66.
Nagda, C., Chotai, N. P., Patel, U., Patel, S., Soni, T., Patel, P., & Hingorani, L. (2009). Preparation and characterization of spray-dried mucoadhesive microspheres of aceclofenac. Drug Development and Industrial Pharmacy, 35(10), 1155-66. https://doi.org/10.1080/03639040902810422
Nagda C, et al. Preparation and Characterization of Spray-dried Mucoadhesive Microspheres of Aceclofenac. Drug Dev Ind Pharm. 2009;35(10):1155-66. PubMed PMID: 19555239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and characterization of spray-dried mucoadhesive microspheres of aceclofenac. AU - Nagda,Chirag, AU - Chotai,Narendra Prabhudas, AU - Patel,Upendra, AU - Patel,Sandip, AU - Soni,Tejal, AU - Patel,Prateek, AU - Hingorani,Lal, PY - 2009/6/27/entrez PY - 2009/6/27/pubmed PY - 2010/1/15/medline SP - 1155 EP - 66 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 35 IS - 10 N2 - OBJECTIVE: Microencapsulation of the anti-inflammatory drug aceclofenac (ACE) was investigated as a means of controlling drug release and minimizing or eliminating local side effects. METHOD: Microspheres were prepared by a spray-drying technique using solutions of ACE and three polymers, namely, carbopol, chitosan, and polycarbophil, in different weight ratios. RESULTS: The spray-dried mucoadhesive microspheres were characterized in terms of shape (scanning electron microscope), size (6.60-8.40 mum), production yield (34.10-55.62%), and encapsulation efficiency (58.14-90.57%). In vitro release studies were performed in phosphate buffer (pH 6.8) up to 10 hours. The spray-drying process of solutions of ACE with polymeric blends can give prolonged drug release. The in vitro release data were well fit into Higuchi and Korsmeyer-Peppas model and followed Fickian diffusion mechanism. In vivo data showed that the administration of ACE in polymeric microspheres prevented the gastric side effects. CONCLUSION: The formulations here described can be proposed for the oral administration of nonsteroidal anti-inflammatory drugs with minimal side effects on gastric mucosa. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/19555239/Preparation_and_characterization_of_spray_dried_mucoadhesive_microspheres_of_aceclofenac_ L2 - http://www.tandfonline.com/doi/full/10.1080/03639040902810422 DB - PRIME DP - Unbound Medicine ER -