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Influence of soluble and insoluble cyclodextrin polymers on drug release from hydroxypropyl methylcellulose tablets.
Drug Dev Ind Pharm. 2009 Oct; 35(10):1264-70.DD

Abstract

BACKGROUND

The influence of beta-cyclodextrin (beta-CD) polymers on drug release from hydroxypropyl methylcellulose (HPMC) matrices has not been reported in the literature.

AIM

The influence of monomeric beta-CD and both soluble and insoluble beta-CD polymers on drug release from tablets containing either 30% or 50% hydroxypropyl methylcellulose has been studied using diflunisal (DF) as model drug.

METHOD

The DF-beta-CD inclusion complex (1:1 M) was prepared by coevaporation and characterised using X-ray diffraction, differential thermal analysis, and IR spectroscopy. The dissolution assays were performed according to the USP paddle method.

RESULTS

The incorporation of beta-CD in the complexed form increases drug release from hydroxypropyl methylcellulose tablets in comparison with the physical mixture because of the better solubilization of the drug. The soluble polymer promotes drug release to a higher extent than the physical mixture with monomeric beta-CD, but the insoluble polymer, which is itself a hydrogel, gives rise to the most retarded release profile, probably by retention of the drug in its structure. The formulations containing physical mixtures with either beta-CD or the soluble polymer present an optimum adjustment to zero-order release kinetics, and the inclusion complex followed non-Fickian diffusion according to the Korsmeyer-Peppas model.

CONCLUSION

The release profile of DF from a HPMC matrix can be modulated in different ways by the use of either monomeric or polymeric beta-CD.

Authors+Show Affiliations

Department of Pharmacy and Pharmaceutical Technology, University of Navarra, Pamplona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19555243

Citation

Zugasti, Maria Esther, et al. "Influence of Soluble and Insoluble Cyclodextrin Polymers On Drug Release From Hydroxypropyl Methylcellulose Tablets." Drug Development and Industrial Pharmacy, vol. 35, no. 10, 2009, pp. 1264-70.
Zugasti ME, Zornoza A, Goñi Mdel M, et al. Influence of soluble and insoluble cyclodextrin polymers on drug release from hydroxypropyl methylcellulose tablets. Drug Dev Ind Pharm. 2009;35(10):1264-70.
Zugasti, M. E., Zornoza, A., Goñi, M. d. e. l. . M., Isasi, J. R., Vélaz, I., Martín, C., Sánchez, M., & Martínez-Ohárriz, M. C. (2009). Influence of soluble and insoluble cyclodextrin polymers on drug release from hydroxypropyl methylcellulose tablets. Drug Development and Industrial Pharmacy, 35(10), 1264-70. https://doi.org/10.1080/03639040902882306
Zugasti ME, et al. Influence of Soluble and Insoluble Cyclodextrin Polymers On Drug Release From Hydroxypropyl Methylcellulose Tablets. Drug Dev Ind Pharm. 2009;35(10):1264-70. PubMed PMID: 19555243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of soluble and insoluble cyclodextrin polymers on drug release from hydroxypropyl methylcellulose tablets. AU - Zugasti,Maria Esther, AU - Zornoza,Arantza, AU - Goñi,María Del Mar, AU - Isasi,José Ramón, AU - Vélaz,Itziar, AU - Martín,Carmen, AU - Sánchez,Miguel, AU - Martínez-Ohárriz,María Cristina, PY - 2009/6/27/entrez PY - 2009/6/27/pubmed PY - 2010/1/15/medline SP - 1264 EP - 70 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 35 IS - 10 N2 - BACKGROUND: The influence of beta-cyclodextrin (beta-CD) polymers on drug release from hydroxypropyl methylcellulose (HPMC) matrices has not been reported in the literature. AIM: The influence of monomeric beta-CD and both soluble and insoluble beta-CD polymers on drug release from tablets containing either 30% or 50% hydroxypropyl methylcellulose has been studied using diflunisal (DF) as model drug. METHOD: The DF-beta-CD inclusion complex (1:1 M) was prepared by coevaporation and characterised using X-ray diffraction, differential thermal analysis, and IR spectroscopy. The dissolution assays were performed according to the USP paddle method. RESULTS: The incorporation of beta-CD in the complexed form increases drug release from hydroxypropyl methylcellulose tablets in comparison with the physical mixture because of the better solubilization of the drug. The soluble polymer promotes drug release to a higher extent than the physical mixture with monomeric beta-CD, but the insoluble polymer, which is itself a hydrogel, gives rise to the most retarded release profile, probably by retention of the drug in its structure. The formulations containing physical mixtures with either beta-CD or the soluble polymer present an optimum adjustment to zero-order release kinetics, and the inclusion complex followed non-Fickian diffusion according to the Korsmeyer-Peppas model. CONCLUSION: The release profile of DF from a HPMC matrix can be modulated in different ways by the use of either monomeric or polymeric beta-CD. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/19555243/Influence_of_soluble_and_insoluble_cyclodextrin_polymers_on_drug_release_from_hydroxypropyl_methylcellulose_tablets_ DB - PRIME DP - Unbound Medicine ER -