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Controlled-release carbamazepine matrix granules and tablets comprising lipophilic and hydrophilic components.
Drug Deliv. 2009 Jan; 16(1):57-65.DD

Abstract

The objective of this study was to investigate the effect of lipophilic (Compritol 888 ATO) and hydrophilic components (combination of HPMC and Avicel) on the release of carbamazepine from granules and corresponding tablet. Wet granulation followed by compression was employed for preparation of granules and tablets. The matrix swelling behavior was investigated. The dissolution profiles of each formulation were compared to those of Tegretol CR tablets and the mean dissolution time (MDT), dissolution efficiency (DE%), and similarity factor (f(2) factor) were calculated. It was found that increase in the concentration of HPMC results in reduction in the release rate from granules and achievement of zero-order is difficult from the granules. The amount of HPMC plays a dominant role for the drug release. The release mechanism of CBZ from matrix tablet formulations follows non-Fickian diffusion shifting to Case II by the increase of HPMC content, indicating significant contribution of erosion. Increasing in drug loading resulted in acceleration of the drug release and in anomalous controlled-release mechanism due to delayed hydration of the tablets. These results suggest that wet granulation followed by compression could be a suitable method to formulate sustained release CBZ tablets.

Authors+Show Affiliations

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. nsybarakat@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19555310

Citation

Barakat, Nahla S., et al. "Controlled-release Carbamazepine Matrix Granules and Tablets Comprising Lipophilic and Hydrophilic Components." Drug Delivery, vol. 16, no. 1, 2009, pp. 57-65.
Barakat NS, Elbagory IM, Almurshedi AS. Controlled-release carbamazepine matrix granules and tablets comprising lipophilic and hydrophilic components. Drug Deliv. 2009;16(1):57-65.
Barakat, N. S., Elbagory, I. M., & Almurshedi, A. S. (2009). Controlled-release carbamazepine matrix granules and tablets comprising lipophilic and hydrophilic components. Drug Delivery, 16(1), 57-65. https://doi.org/10.1080/10717540802518157
Barakat NS, Elbagory IM, Almurshedi AS. Controlled-release Carbamazepine Matrix Granules and Tablets Comprising Lipophilic and Hydrophilic Components. Drug Deliv. 2009;16(1):57-65. PubMed PMID: 19555310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Controlled-release carbamazepine matrix granules and tablets comprising lipophilic and hydrophilic components. AU - Barakat,Nahla S, AU - Elbagory,Ibrahim M, AU - Almurshedi,Alanood S, PY - 2009/6/27/entrez PY - 2009/6/27/pubmed PY - 2009/10/1/medline SP - 57 EP - 65 JF - Drug delivery JO - Drug Deliv VL - 16 IS - 1 N2 - The objective of this study was to investigate the effect of lipophilic (Compritol 888 ATO) and hydrophilic components (combination of HPMC and Avicel) on the release of carbamazepine from granules and corresponding tablet. Wet granulation followed by compression was employed for preparation of granules and tablets. The matrix swelling behavior was investigated. The dissolution profiles of each formulation were compared to those of Tegretol CR tablets and the mean dissolution time (MDT), dissolution efficiency (DE%), and similarity factor (f(2) factor) were calculated. It was found that increase in the concentration of HPMC results in reduction in the release rate from granules and achievement of zero-order is difficult from the granules. The amount of HPMC plays a dominant role for the drug release. The release mechanism of CBZ from matrix tablet formulations follows non-Fickian diffusion shifting to Case II by the increase of HPMC content, indicating significant contribution of erosion. Increasing in drug loading resulted in acceleration of the drug release and in anomalous controlled-release mechanism due to delayed hydration of the tablets. These results suggest that wet granulation followed by compression could be a suitable method to formulate sustained release CBZ tablets. SN - 1521-0464 UR - https://www.unboundmedicine.com/medline/citation/19555310/Controlled_release_carbamazepine_matrix_granules_and_tablets_comprising_lipophilic_and_hydrophilic_components_ L2 - http://www.tandfonline.com/doi/full/10.1080/10717540802518157 DB - PRIME DP - Unbound Medicine ER -