Tags

Type your tag names separated by a space and hit enter

Involvement of neuropeptide Y in the acute, chronic and withdrawal responses of morphine in nociception in neuropathic rats: behavioral and neuroanatomical correlates.
Neuropeptides. 2009 Aug; 43(4):303-14.N

Abstract

Although morphine is a potent antinociceptive agent, its chronic use developed tolerance in neuropathic pain (NP). Furthermore, opioid antagonist naloxone attenuated the antinociceptive effect of neuropeptide Y (NPY). The present study investigated the role of NPY and NPY Y1/Y5 receptors in acute and chronic actions of morphine in neuropathic rats using thermal paw withdrawal test and immunocytochemistry. In acute study, intracerebroventricular (icv) administration of morphine, NPY or NPY Y1/Y5 receptors agonist [Leu(31),Pro(34)]-NPY produced antinociception, whereas selective NPY Y1 receptors antagonist BIBP3226 caused hyperalgesia. While NPY or [Leu(31),Pro(34)]-NPY potentiated, BIBP3226 attenuated morphine induced antinociception. Chronic icv infusion of morphine via osmotic minipumps developed tolerance to its antinociceptive effect, and produced hyperalgesia following withdrawal. However, co-administration of NPY or [Leu(31),Pro(34)]-NPY prevented the development of tolerance and withdrawal hyperalgesia. Sciatic nerve ligation resulted in significant increase in the NPY-immunoreactive (NPY-ir) fibers in ventrolateral periaqueductal gray (VLPAG) and locus coeruleus (LC); fibers in the dorsal part of dorsal raphe nucleus (DRD) did not respond. While chronic morphine treatment significantly reduced NPY-ir fibers in VLPAG and DRD, morphine withdrawal triggered significant augmentation in NPY-immunoreactivity in the VLPAG. NPY-immunoreactivity profile of LC remained unchanged in all the morphine treatment conditions. Furthermore, removal of sciatic nerve ligation reversed the effects of NP, increased pain threshold and restored NPY-ir fiber population in VLPAG. NPY, perhaps acting via Y1/Y5 receptors, might profoundly influence the processing of NP information and interact with the endogenous opioid system primarily within the framework of the VLPAG.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Nagpur 440 033, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19556004

Citation

Upadhya, Manoj A., et al. "Involvement of Neuropeptide Y in the Acute, Chronic and Withdrawal Responses of Morphine in Nociception in Neuropathic Rats: Behavioral and Neuroanatomical Correlates." Neuropeptides, vol. 43, no. 4, 2009, pp. 303-14.
Upadhya MA, Dandekar MP, Kokare DM, et al. Involvement of neuropeptide Y in the acute, chronic and withdrawal responses of morphine in nociception in neuropathic rats: behavioral and neuroanatomical correlates. Neuropeptides. 2009;43(4):303-14.
Upadhya, M. A., Dandekar, M. P., Kokare, D. M., Singru, P. S., & Subhedar, N. K. (2009). Involvement of neuropeptide Y in the acute, chronic and withdrawal responses of morphine in nociception in neuropathic rats: behavioral and neuroanatomical correlates. Neuropeptides, 43(4), 303-14. https://doi.org/10.1016/j.npep.2009.05.003
Upadhya MA, et al. Involvement of Neuropeptide Y in the Acute, Chronic and Withdrawal Responses of Morphine in Nociception in Neuropathic Rats: Behavioral and Neuroanatomical Correlates. Neuropeptides. 2009;43(4):303-14. PubMed PMID: 19556004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of neuropeptide Y in the acute, chronic and withdrawal responses of morphine in nociception in neuropathic rats: behavioral and neuroanatomical correlates. AU - Upadhya,Manoj A, AU - Dandekar,Manoj P, AU - Kokare,Dadasaheb M, AU - Singru,Praful S, AU - Subhedar,Nishikant K, Y1 - 2009/06/24/ PY - 2009/02/04/received PY - 2009/05/14/revised PY - 2009/05/20/accepted PY - 2009/6/27/entrez PY - 2009/6/27/pubmed PY - 2009/10/15/medline SP - 303 EP - 14 JF - Neuropeptides JO - Neuropeptides VL - 43 IS - 4 N2 - Although morphine is a potent antinociceptive agent, its chronic use developed tolerance in neuropathic pain (NP). Furthermore, opioid antagonist naloxone attenuated the antinociceptive effect of neuropeptide Y (NPY). The present study investigated the role of NPY and NPY Y1/Y5 receptors in acute and chronic actions of morphine in neuropathic rats using thermal paw withdrawal test and immunocytochemistry. In acute study, intracerebroventricular (icv) administration of morphine, NPY or NPY Y1/Y5 receptors agonist [Leu(31),Pro(34)]-NPY produced antinociception, whereas selective NPY Y1 receptors antagonist BIBP3226 caused hyperalgesia. While NPY or [Leu(31),Pro(34)]-NPY potentiated, BIBP3226 attenuated morphine induced antinociception. Chronic icv infusion of morphine via osmotic minipumps developed tolerance to its antinociceptive effect, and produced hyperalgesia following withdrawal. However, co-administration of NPY or [Leu(31),Pro(34)]-NPY prevented the development of tolerance and withdrawal hyperalgesia. Sciatic nerve ligation resulted in significant increase in the NPY-immunoreactive (NPY-ir) fibers in ventrolateral periaqueductal gray (VLPAG) and locus coeruleus (LC); fibers in the dorsal part of dorsal raphe nucleus (DRD) did not respond. While chronic morphine treatment significantly reduced NPY-ir fibers in VLPAG and DRD, morphine withdrawal triggered significant augmentation in NPY-immunoreactivity in the VLPAG. NPY-immunoreactivity profile of LC remained unchanged in all the morphine treatment conditions. Furthermore, removal of sciatic nerve ligation reversed the effects of NP, increased pain threshold and restored NPY-ir fiber population in VLPAG. NPY, perhaps acting via Y1/Y5 receptors, might profoundly influence the processing of NP information and interact with the endogenous opioid system primarily within the framework of the VLPAG. SN - 1532-2785 UR - https://www.unboundmedicine.com/medline/citation/19556004/Involvement_of_neuropeptide_Y_in_the_acute_chronic_and_withdrawal_responses_of_morphine_in_nociception_in_neuropathic_rats:_behavioral_and_neuroanatomical_correlates_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0143-4179(09)00049-3 DB - PRIME DP - Unbound Medicine ER -