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High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease.
J Infect. 2009 Aug; 59(2):115-21.JI

Abstract

OBJECTIVE

To determine the prevalence of human rhinoviruses (HRV) infections in children with lower respiratory disease in Thailand and monitor the association between species of HRV and clinical presentation in hospitalized paediatric patients.

METHOD

Two hundred and eighty-nine nasopharyngeal (NP) suction specimens were collected from hospitalized paediatric patients admitted to King Chulalongkorn Memorial Hospital, Thailand during February 2006-2007. Nucleic acids were extracted from each sample with subsequent amplification of VP4/2 by semi-nested RT-PCR for HRV detection. Other viral respiratory pathogens were also detected by PCR, RT-PCR or real time PCR. Nucleotide sequences of the VP4 region were used for genotyping and phylogenetic tree construction.

RESULT

In total, 87 of 289 specimens were positive for HRV indicating an annual prevalence of 30%. Wheezing or asthma exacerbation was the most common clinical presentation observed in infected patients. Sequence analysis and phylogenetic tree showed that 29 (33%) and 8 (9%) specimens belonged to HRV-A and HRV-B, respectively. Most of the HRV positive samples were HRV-C (58%). Moreover, species C was predominantly found in the paediatric population of Thailand in raining season (p<0.05). The frequency of co-infection of HRV-C with other respiratory viral pathogens was approximately 40%.

CONCLUSION

HRV-C represents the predominant species and is one of the etiologic agents in acute lower respiratory tract infection, causes of wheezing and asthma exacerbation in infants and young children in Thailand.

Authors+Show Affiliations

Center of Excellence in Clinical Virology, Department of Paediatrics, Chulalongkorn University, Rama IV, Patumwan, Bangkok 10330, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19556008

Citation

Linsuwanon, Piyada, et al. "High Prevalence of Human Rhinovirus C Infection in Thai Children With Acute Lower Respiratory Tract Disease." The Journal of Infection, vol. 59, no. 2, 2009, pp. 115-21.
Linsuwanon P, Payungporn S, Samransamruajkit R, et al. High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease. J Infect. 2009;59(2):115-21.
Linsuwanon, P., Payungporn, S., Samransamruajkit, R., Posuwan, N., Makkoch, J., Theanboonlers, A., & Poovorawan, Y. (2009). High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease. The Journal of Infection, 59(2), 115-21. https://doi.org/10.1016/j.jinf.2009.05.009
Linsuwanon P, et al. High Prevalence of Human Rhinovirus C Infection in Thai Children With Acute Lower Respiratory Tract Disease. J Infect. 2009;59(2):115-21. PubMed PMID: 19556008.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease. AU - Linsuwanon,Piyada, AU - Payungporn,Sunchai, AU - Samransamruajkit,Rujipat, AU - Posuwan,Nawarat, AU - Makkoch,Jarika, AU - Theanboonlers,Apiradee, AU - Poovorawan,Yong, Y1 - 2009/06/06/ PY - 2009/02/24/received PY - 2009/05/22/revised PY - 2009/05/22/accepted PY - 2009/6/27/entrez PY - 2009/6/27/pubmed PY - 2009/10/2/medline SP - 115 EP - 21 JF - The Journal of infection JO - J Infect VL - 59 IS - 2 N2 - OBJECTIVE: To determine the prevalence of human rhinoviruses (HRV) infections in children with lower respiratory disease in Thailand and monitor the association between species of HRV and clinical presentation in hospitalized paediatric patients. METHOD: Two hundred and eighty-nine nasopharyngeal (NP) suction specimens were collected from hospitalized paediatric patients admitted to King Chulalongkorn Memorial Hospital, Thailand during February 2006-2007. Nucleic acids were extracted from each sample with subsequent amplification of VP4/2 by semi-nested RT-PCR for HRV detection. Other viral respiratory pathogens were also detected by PCR, RT-PCR or real time PCR. Nucleotide sequences of the VP4 region were used for genotyping and phylogenetic tree construction. RESULT: In total, 87 of 289 specimens were positive for HRV indicating an annual prevalence of 30%. Wheezing or asthma exacerbation was the most common clinical presentation observed in infected patients. Sequence analysis and phylogenetic tree showed that 29 (33%) and 8 (9%) specimens belonged to HRV-A and HRV-B, respectively. Most of the HRV positive samples were HRV-C (58%). Moreover, species C was predominantly found in the paediatric population of Thailand in raining season (p<0.05). The frequency of co-infection of HRV-C with other respiratory viral pathogens was approximately 40%. CONCLUSION: HRV-C represents the predominant species and is one of the etiologic agents in acute lower respiratory tract infection, causes of wheezing and asthma exacerbation in infants and young children in Thailand. SN - 1532-2742 UR - https://www.unboundmedicine.com/medline/citation/19556008/High_prevalence_of_human_rhinovirus_C_infection_in_Thai_children_with_acute_lower_respiratory_tract_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-4453(09)00156-X DB - PRIME DP - Unbound Medicine ER -