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[Megaloblastic-vitamin B12 deficiency anemia in childhood].
Georgian Med News. 2009 MayGM

Abstract

Megaloblastic anemias are basically caused by vitamin B(12) and/or folic acid deficiency. Childhood vitamin B(12) deficiency is extremely rare. There are congenital and acquired forms of vitamin B(12)-deficiency anemias. The article captures findings of 10 year observation of 3 patients with Imerslund-Gräsbeck Syndrome (congenital chronic megaloblastic anemia with proteinuria), in which the diagnosis was established by us in early childhood and due to correct treatment and prevention complete clinical-laboratory remission is kept so far. We have also observed rare case of acquired megaloblastic anemia - 14 years old vegetarian patient, who was diagnosed with vitamin B(12)-deficiency anemia based on history, clinical and para-clinical data. It was caused by strict vegetarianism of the patient. Therefore first of all the diet was corrected. In 5 days of specific treatment with vitamin B(12) "reticulocyte crisis" was manifested (proving the correctness of diagnosis and treatment) and complete clinical-hematological remission was achieved in 2 weeks. The given cases are interesting as megaloblastic anemias in childhood are both rare and difficult to diagnose. In such cases timely diagnosis, treatment and prevention tactics should be based on cause-and-effect relation of disease.

Authors

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Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

rus

PubMed ID

19556642

Citation

Mtvarelidze, Z G., et al. "[Megaloblastic-vitamin B12 Deficiency Anemia in Childhood]." Georgian Medical News, 2009, pp. 57-60.
Mtvarelidze ZG, Kvezereli-Kopadze AN, Kvezereli-Kopadze MA. [Megaloblastic-vitamin B12 deficiency anemia in childhood]. Georgian Med News. 2009.
Mtvarelidze, Z. G., Kvezereli-Kopadze, A. N., & Kvezereli-Kopadze, M. A. (2009). [Megaloblastic-vitamin B12 deficiency anemia in childhood]. Georgian Medical News, (170), 57-60.
Mtvarelidze ZG, Kvezereli-Kopadze AN, Kvezereli-Kopadze MA. [Megaloblastic-vitamin B12 Deficiency Anemia in Childhood]. Georgian Med News. 2009;(170)57-60. PubMed PMID: 19556642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Megaloblastic-vitamin B12 deficiency anemia in childhood]. AU - Mtvarelidze,Z G, AU - Kvezereli-Kopadze,A N, AU - Kvezereli-Kopadze,M A, PY - 2009/6/27/entrez PY - 2009/6/27/pubmed PY - 2009/10/10/medline SP - 57 EP - 60 JF - Georgian medical news JO - Georgian Med News IS - 170 N2 - Megaloblastic anemias are basically caused by vitamin B(12) and/or folic acid deficiency. Childhood vitamin B(12) deficiency is extremely rare. There are congenital and acquired forms of vitamin B(12)-deficiency anemias. The article captures findings of 10 year observation of 3 patients with Imerslund-Gräsbeck Syndrome (congenital chronic megaloblastic anemia with proteinuria), in which the diagnosis was established by us in early childhood and due to correct treatment and prevention complete clinical-laboratory remission is kept so far. We have also observed rare case of acquired megaloblastic anemia - 14 years old vegetarian patient, who was diagnosed with vitamin B(12)-deficiency anemia based on history, clinical and para-clinical data. It was caused by strict vegetarianism of the patient. Therefore first of all the diet was corrected. In 5 days of specific treatment with vitamin B(12) "reticulocyte crisis" was manifested (proving the correctness of diagnosis and treatment) and complete clinical-hematological remission was achieved in 2 weeks. The given cases are interesting as megaloblastic anemias in childhood are both rare and difficult to diagnose. In such cases timely diagnosis, treatment and prevention tactics should be based on cause-and-effect relation of disease. SN - 1512-0112 UR - https://www.unboundmedicine.com/medline/citation/19556642/[Megaloblastic_vitamin_B12_deficiency_anemia_in_childhood]_ L2 - http://www.diseaseinfosearch.org/result/4562 DB - PRIME DP - Unbound Medicine ER -