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Antinociceptive and anti-inflammatory effects of the ethanol extract of Alpinia conchigera Griff. leaves in various animal models.
Methods Find Exp Clin Pharmacol. 2009 May; 31(4):241-7.MF

Abstract

The ethanolic extract of Alpinia conchigera Griff. leaves (EACL) was evaluated for its antinociceptive and anti-inflammatory activities in several in vivo experimental models. Antinociceptive activity was determined using the acetic acid-induced abdominal writhing test, the hot plate test and the formalin test. Anti-inflammatory activity was determined using the carrageenan-induced paw edema test. The extract (30, 100 and 300 mg/kg i.p.) was found to possess significant, dose-dependent inhibitory activity in all test models. In addition, the antinociceptive effect of the extract in the acetic acid-induced writhing and hot plate tests was reversed by naloxone, suggesting that this activity is mediated through activation of the opioid system. These findings suggest that EACL presents notable analgesic and anti-inflammatory activities, which support its folkloric use for painful and inflammatory conditions.

Authors+Show Affiliations

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia. mrs@medic.upm.edu.myNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19557202

Citation

Sulaiman, M R., et al. "Antinociceptive and Anti-inflammatory Effects of the Ethanol Extract of Alpinia Conchigera Griff. Leaves in Various Animal Models." Methods and Findings in Experimental and Clinical Pharmacology, vol. 31, no. 4, 2009, pp. 241-7.
Sulaiman MR, Zakaria ZA, Adilius M, et al. Antinociceptive and anti-inflammatory effects of the ethanol extract of Alpinia conchigera Griff. leaves in various animal models. Methods Find Exp Clin Pharmacol. 2009;31(4):241-7.
Sulaiman, M. R., Zakaria, Z. A., Adilius, M., Mohamad, A. S., Ismail, M., & Israf, D. A. (2009). Antinociceptive and anti-inflammatory effects of the ethanol extract of Alpinia conchigera Griff. leaves in various animal models. Methods and Findings in Experimental and Clinical Pharmacology, 31(4), 241-7. https://doi.org/10.1358/mf.2009.31.4.1371198
Sulaiman MR, et al. Antinociceptive and Anti-inflammatory Effects of the Ethanol Extract of Alpinia Conchigera Griff. Leaves in Various Animal Models. Methods Find Exp Clin Pharmacol. 2009;31(4):241-7. PubMed PMID: 19557202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive and anti-inflammatory effects of the ethanol extract of Alpinia conchigera Griff. leaves in various animal models. AU - Sulaiman,M R, AU - Zakaria,Z A, AU - Adilius,M, AU - Mohamad,A S, AU - Ismail,M, AU - Israf,D A, PY - 2009/6/27/entrez PY - 2009/6/27/pubmed PY - 2009/9/4/medline SP - 241 EP - 7 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 31 IS - 4 N2 - The ethanolic extract of Alpinia conchigera Griff. leaves (EACL) was evaluated for its antinociceptive and anti-inflammatory activities in several in vivo experimental models. Antinociceptive activity was determined using the acetic acid-induced abdominal writhing test, the hot plate test and the formalin test. Anti-inflammatory activity was determined using the carrageenan-induced paw edema test. The extract (30, 100 and 300 mg/kg i.p.) was found to possess significant, dose-dependent inhibitory activity in all test models. In addition, the antinociceptive effect of the extract in the acetic acid-induced writhing and hot plate tests was reversed by naloxone, suggesting that this activity is mediated through activation of the opioid system. These findings suggest that EACL presents notable analgesic and anti-inflammatory activities, which support its folkloric use for painful and inflammatory conditions. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/19557202/Antinociceptive_and_anti_inflammatory_effects_of_the_ethanol_extract_of_Alpinia_conchigera_Griff__leaves_in_various_animal_models_ L2 - http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summaryn_pr?p_JournalId=6&p_RefId=1371198 DB - PRIME DP - Unbound Medicine ER -