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Influence of highly active antiretroviral treatment (HAART) on risk factors for vertical HIV transmission.
Acta Obstet Gynecol Scand. 2009; 88(8):882-7.AO

Abstract

OBJECTIVE

To analyze the influence of highly active antiretroviral treatment (HAART) on risk factors for perinatal transmission of human immunodeficiency virus (HIV).

DESIGN

A prospective cohort study was performed between HIV pregnant women under HAART therapy and without treatment.

SETTING

The maternity hospital 'La Fe' in Valencia, Spain.

POPULATION OR SAMPLE

Five hundred HIV-positive pregnant women.

METHOD

Known maternal and obstetrical perinatal risk factors were analyzed by univariate and multivariate methods (logistic regression). The influence of HAART on the risk factors was evaluated independently to determine whether there was a modulation in perinatal HIV transmission.

MAIN OUTCOME MEASURES

Known perinatal risk factors were found not to have any significant influence on perinatal HIV transmission in women under HAART therapy.

RESULTS

Vertical transmission risk decreased significantly from 18.2% without treatment to 8.6% with mono/dual therapy and 0.6% with HAART. A CD4+ cell count below 500 cell/microl, intrapartum use of invasive procedures, rupture of membranes >six hours, labor length >five hours, and birthweight were the significant risk factors associated to vertical HIV transmission and elective cesarean section. Antiretroviral treatment administered during delivery was a protective factor in HIV pregnant women before HAART therapy.

CONCLUSIONS

HAART therapy reduces the influence of the perinatal risk factors on vertical HIV transmission.

Authors+Show Affiliations

Department of Obstetric, Hospital Maternal La Fe, Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19557554

Citation

Garcia-Tejedor, Amparo, et al. "Influence of Highly Active Antiretroviral Treatment (HAART) On Risk Factors for Vertical HIV Transmission." Acta Obstetricia Et Gynecologica Scandinavica, vol. 88, no. 8, 2009, pp. 882-7.
Garcia-Tejedor A, Maiques V, Perales A, et al. Influence of highly active antiretroviral treatment (HAART) on risk factors for vertical HIV transmission. Acta Obstet Gynecol Scand. 2009;88(8):882-7.
Garcia-Tejedor, A., Maiques, V., Perales, A., & Lopez-Aldeguer, J. (2009). Influence of highly active antiretroviral treatment (HAART) on risk factors for vertical HIV transmission. Acta Obstetricia Et Gynecologica Scandinavica, 88(8), 882-7. https://doi.org/10.1080/00016340903062836
Garcia-Tejedor A, et al. Influence of Highly Active Antiretroviral Treatment (HAART) On Risk Factors for Vertical HIV Transmission. Acta Obstet Gynecol Scand. 2009;88(8):882-7. PubMed PMID: 19557554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of highly active antiretroviral treatment (HAART) on risk factors for vertical HIV transmission. AU - Garcia-Tejedor,Amparo, AU - Maiques,Vicente, AU - Perales,Alfredo, AU - Lopez-Aldeguer,Jose, PY - 2009/6/27/entrez PY - 2009/6/27/pubmed PY - 2009/8/11/medline SP - 882 EP - 7 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 88 IS - 8 N2 - OBJECTIVE: To analyze the influence of highly active antiretroviral treatment (HAART) on risk factors for perinatal transmission of human immunodeficiency virus (HIV). DESIGN: A prospective cohort study was performed between HIV pregnant women under HAART therapy and without treatment. SETTING: The maternity hospital 'La Fe' in Valencia, Spain. POPULATION OR SAMPLE: Five hundred HIV-positive pregnant women. METHOD: Known maternal and obstetrical perinatal risk factors were analyzed by univariate and multivariate methods (logistic regression). The influence of HAART on the risk factors was evaluated independently to determine whether there was a modulation in perinatal HIV transmission. MAIN OUTCOME MEASURES: Known perinatal risk factors were found not to have any significant influence on perinatal HIV transmission in women under HAART therapy. RESULTS: Vertical transmission risk decreased significantly from 18.2% without treatment to 8.6% with mono/dual therapy and 0.6% with HAART. A CD4+ cell count below 500 cell/microl, intrapartum use of invasive procedures, rupture of membranes >six hours, labor length >five hours, and birthweight were the significant risk factors associated to vertical HIV transmission and elective cesarean section. Antiretroviral treatment administered during delivery was a protective factor in HIV pregnant women before HAART therapy. CONCLUSIONS: HAART therapy reduces the influence of the perinatal risk factors on vertical HIV transmission. SN - 1600-0412 UR - https://www.unboundmedicine.com/medline/citation/19557554/Influence_of_highly_active_antiretroviral_treatment__HAART__on_risk_factors_for_vertical_HIV_transmission_ L2 - https://doi.org/10.1080/00016340903062836 DB - PRIME DP - Unbound Medicine ER -