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Polymorphism of Pro12Ala in the peroxisome proliferator-activated receptor gamma2 gene in Iranian diabetic and obese subjects.
Metab Syndr Relat Disord. 2009 Oct; 7(5):453-8.MS

Abstract

BACKGROUND

Peroxisome proliferator-activated receptor gamma2 (PPARgamma2) is a nuclear receptor that regulates adipocyte differentiation, lipid metabolism, and insulin sensitivity. The aim of this study was to investigate the association between the Pro12Ala single nucleotide polymorphism (SNP) at the PPARgamma2 gene and type II diabetes (T2DM) and obesity in an Iranian population.

METHODS

The genomic DNA of the 312 subjects included four groups: (1) nonobese with type II diabetes, (2) obese without type II diabetes, (3) obese with type II diabetes, and (4) nondiabetic nonobese controls. The Pro12Ala polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis.

RESULTS

Frequencies of the Ala allele in obese subjects were significantly different from those control subjects (odds ratio [OR], 2.358; 95% confidence interval [CI], 1.101-5.05) (P = 0.025). In contrast, no significant association was detected between the Pro12Ala polymorphism and type II diabetes (OR, 0.652; 95% CI, 0.261-1.628). In all subjects, the Ala carriers had a higher body mass index (BMI) compared with the common allele.

CONCLUSIONS

Our results showed that the Pro12Ala polymorphism in the PPARgamma2 gene is associated with obesity in Iranian subjects and the presence of the Ala allele could predict higher BMI.

Authors+Show Affiliations

Department of Hygiene, Golestan University of Medical Sciences, Gorgan, Iran. swt_f@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19558269

Citation

Mirzaei, Hassan, et al. "Polymorphism of Pro12Ala in the Peroxisome Proliferator-activated Receptor Gamma2 Gene in Iranian Diabetic and Obese Subjects." Metabolic Syndrome and Related Disorders, vol. 7, no. 5, 2009, pp. 453-8.
Mirzaei H, Akrami SM, Golmohammadi T, et al. Polymorphism of Pro12Ala in the peroxisome proliferator-activated receptor gamma2 gene in Iranian diabetic and obese subjects. Metab Syndr Relat Disord. 2009;7(5):453-8.
Mirzaei, H., Akrami, S. M., Golmohammadi, T., Doosti, M., Heshmat, R., Nakhjavani, M., & Amiri, P. (2009). Polymorphism of Pro12Ala in the peroxisome proliferator-activated receptor gamma2 gene in Iranian diabetic and obese subjects. Metabolic Syndrome and Related Disorders, 7(5), 453-8. https://doi.org/10.1089/met.2008.0099
Mirzaei H, et al. Polymorphism of Pro12Ala in the Peroxisome Proliferator-activated Receptor Gamma2 Gene in Iranian Diabetic and Obese Subjects. Metab Syndr Relat Disord. 2009;7(5):453-8. PubMed PMID: 19558269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphism of Pro12Ala in the peroxisome proliferator-activated receptor gamma2 gene in Iranian diabetic and obese subjects. AU - Mirzaei,Hassan, AU - Akrami,Seyed Mohammad, AU - Golmohammadi,Taghi, AU - Doosti,Mahmood, AU - Heshmat,Ramin, AU - Nakhjavani,Manouchehr, AU - Amiri,Parvin, PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2009/12/18/medline SP - 453 EP - 8 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 7 IS - 5 N2 - BACKGROUND: Peroxisome proliferator-activated receptor gamma2 (PPARgamma2) is a nuclear receptor that regulates adipocyte differentiation, lipid metabolism, and insulin sensitivity. The aim of this study was to investigate the association between the Pro12Ala single nucleotide polymorphism (SNP) at the PPARgamma2 gene and type II diabetes (T2DM) and obesity in an Iranian population. METHODS: The genomic DNA of the 312 subjects included four groups: (1) nonobese with type II diabetes, (2) obese without type II diabetes, (3) obese with type II diabetes, and (4) nondiabetic nonobese controls. The Pro12Ala polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. RESULTS: Frequencies of the Ala allele in obese subjects were significantly different from those control subjects (odds ratio [OR], 2.358; 95% confidence interval [CI], 1.101-5.05) (P = 0.025). In contrast, no significant association was detected between the Pro12Ala polymorphism and type II diabetes (OR, 0.652; 95% CI, 0.261-1.628). In all subjects, the Ala carriers had a higher body mass index (BMI) compared with the common allele. CONCLUSIONS: Our results showed that the Pro12Ala polymorphism in the PPARgamma2 gene is associated with obesity in Iranian subjects and the presence of the Ala allele could predict higher BMI. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/19558269/Polymorphism_of_Pro12Ala_in_the_peroxisome_proliferator_activated_receptor_gamma2_gene_in_Iranian_diabetic_and_obese_subjects_ L2 - https://www.liebertpub.com/doi/10.1089/met.2008.0099?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -