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Is plasma homocysteine level associated with metabolic syndrome components in adolescents?
Metab Syndr Relat Disord. 2009 Aug; 7(4):357-62.MS

Abstract

BACKGROUND

This study investigated whether serum homocysteine (Hcy) level is associated with metabolic syndrome components, including high waist circumference (WC), hypertriglyceridemia, low high-density lipoprotein-cholesterol (HDL-C), elevated systolic blood pressure (SBP), and insulin resistance (IR) in adolescents living in Central Anatolia, Turkey.

METHODS

The data of The Prevalence of Metabolic Syndrome Among Adolescents Study, a cross-sectional study carried out in two of the central and ten outlying districts of Kayseri was used. Components of metabolic syndrome were modified from the Adult Treatment Panel III (ATP III). A multivariate regression model was developed to examine the relationships between the homocysteine (Hcy) level and metabolic syndrome components. Hyperhomocysteinemia (HH) was defined as level of Hcy > or = 15 micromol/L.

RESULTS

Mean plasma Hcy level of adolescents with metabolic syndrome was found to be 11.8 +/- 5.0 micromol/L. Although the Hcy level of females (11.4 +/- 5.5 micromol/L) was lower than that of males (12.0 +/- 4.7 micromol/L), the difference was not statistically significant (P > 0.05). In all, 40.5% of adolescents had Hcy levels between 10 and 15 micromol/L (mild HH) and 17.7% of adolescents had Hcy levels of > or = 15 micromol/L. The Hcy level was negative and weakly correlated with insulin resistance in females (r = -0.319, P = 0.058) and negative strongly correlated with SBP in males (r = - 0.385, P = 0.011). There were no associations between Hcy level and other components of metabolic syndrome.

CONCLUSIONS

An elevated plasma Hcy level is not considered to be related to components of metabolic syndrome. But HH may be an independent risk factor, especially for diabetic adolescents or those who have cardiovascular events as in adults.

Authors+Show Affiliations

Rectorate, School of Medicine, University of Erciyes, Kayseri 38039, Turkey. nbudak@erciyes.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19558275

Citation

Budak, Nurten, et al. "Is Plasma Homocysteine Level Associated With Metabolic Syndrome Components in Adolescents?" Metabolic Syndrome and Related Disorders, vol. 7, no. 4, 2009, pp. 357-62.
Budak N, Yazici C, Oztürk A, et al. Is plasma homocysteine level associated with metabolic syndrome components in adolescents? Metab Syndr Relat Disord. 2009;7(4):357-62.
Budak, N., Yazici, C., Oztürk, A., Bayram, F., Mazicioğlu, M. M., & Kurtoglu, S. (2009). Is plasma homocysteine level associated with metabolic syndrome components in adolescents? Metabolic Syndrome and Related Disorders, 7(4), 357-62. https://doi.org/10.1089/met.2008.0037
Budak N, et al. Is Plasma Homocysteine Level Associated With Metabolic Syndrome Components in Adolescents. Metab Syndr Relat Disord. 2009;7(4):357-62. PubMed PMID: 19558275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is plasma homocysteine level associated with metabolic syndrome components in adolescents? AU - Budak,Nurten, AU - Yazici,Cevad, AU - Oztürk,Ahmet, AU - Bayram,Fahri, AU - Mazicioğlu,M Mümtaz, AU - Kurtoglu,Selim, PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2009/11/17/medline SP - 357 EP - 62 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 7 IS - 4 N2 - BACKGROUND: This study investigated whether serum homocysteine (Hcy) level is associated with metabolic syndrome components, including high waist circumference (WC), hypertriglyceridemia, low high-density lipoprotein-cholesterol (HDL-C), elevated systolic blood pressure (SBP), and insulin resistance (IR) in adolescents living in Central Anatolia, Turkey. METHODS: The data of The Prevalence of Metabolic Syndrome Among Adolescents Study, a cross-sectional study carried out in two of the central and ten outlying districts of Kayseri was used. Components of metabolic syndrome were modified from the Adult Treatment Panel III (ATP III). A multivariate regression model was developed to examine the relationships between the homocysteine (Hcy) level and metabolic syndrome components. Hyperhomocysteinemia (HH) was defined as level of Hcy > or = 15 micromol/L. RESULTS: Mean plasma Hcy level of adolescents with metabolic syndrome was found to be 11.8 +/- 5.0 micromol/L. Although the Hcy level of females (11.4 +/- 5.5 micromol/L) was lower than that of males (12.0 +/- 4.7 micromol/L), the difference was not statistically significant (P > 0.05). In all, 40.5% of adolescents had Hcy levels between 10 and 15 micromol/L (mild HH) and 17.7% of adolescents had Hcy levels of > or = 15 micromol/L. The Hcy level was negative and weakly correlated with insulin resistance in females (r = -0.319, P = 0.058) and negative strongly correlated with SBP in males (r = - 0.385, P = 0.011). There were no associations between Hcy level and other components of metabolic syndrome. CONCLUSIONS: An elevated plasma Hcy level is not considered to be related to components of metabolic syndrome. But HH may be an independent risk factor, especially for diabetic adolescents or those who have cardiovascular events as in adults. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/19558275/Is_plasma_homocysteine_level_associated_with_metabolic_syndrome_components_in_adolescents L2 - https://www.liebertpub.com/doi/10.1089/met.2008.0037?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -