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[Values of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide in evaluation of cardiac function in children with congenital heart disease].
Zhongguo Dang Dai Er Ke Za Zhi. 2009 Jun; 11(6):429-32.ZD

Abstract

OBJECTIVE

To study the values of brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in the evaluation of cardiac function in children with congenital heart disease (CHD).

METHODS

Seventy-one children with CHD were classified to two groups: congestive heart failure (CHF) (n=23) and non-CHF (n=48). Thirty-five age-matched normal children were used as the control group. Plasma BNP content was measured using a microparticle enzyme immunoassay (MEIA) on the AxSYM. Plasma NT-proBNP content was measured using an automated electrochemiluminescence immunoassay on a Roche Modular Analytics E170 analyzer. Echocardiographic parameters, including left ventricular end diastolic dimension index (LVEDDI) and left ventricular ejection fraction (LVEF), were measured.

RESULTS

Plasma BNP and NT-proBNP contents in the CHF group were significantly higher than those in the non-CHF group (P<0.01). The non-CHF group had higher plasma BNP and NT-proBNP contents than the control group (P<0.01). LogBNP and LogNT-proBNP values were negatively correlated with the LVEF in the CHF group (r=-0.64, r=-0.67 respectively, P<0.01), and they were positively correlated with the LVEDDI (r=0.58, r=0.76 respectively, P<0.01). In the non-CHF group, LogBNP and LogNT-proBNP values were not correlated with the LVEF, but a positive correlation was found between the LogNT-proBNP value and the LVEDDI (r=0.35, P<0.05). Using plasma BNP content > or =149.8 pg/mL and NT-proBNP content > or =820.1 pg/mL as cut-off values for diagnosing CHF respectively, the sensitivities were 87.0 % and 91.3% respectively, the specificities were 91.7% and 97.9% respectively, and the areas under the ROC curves were 0.935 and 0.987 respectively.

CONCLUSIONS

Both BNP and NT-proBNP can be useful in assessment of cardiac function and diagnosis of CHF in children with CHD. NT-proBNP appears to be more sensitive and specific in the diagnosis of CHF than BNP.

Authors+Show Affiliations

Department of Pediatric Cardiology, Yuying Children's Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325027, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19558803

Citation

Zhang, Shen-Rong, et al. "[Values of Brain Natriuretic Peptide and N-terminal Pro-brain Natriuretic Peptide in Evaluation of Cardiac Function in Children With Congenital Heart Disease]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 11, no. 6, 2009, pp. 429-32.
Zhang SR, Zhang YH, Xu Q, et al. [Values of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide in evaluation of cardiac function in children with congenital heart disease]. Zhongguo Dang Dai Er Ke Za Zhi. 2009;11(6):429-32.
Zhang, S. R., Zhang, Y. H., Xu, Q., Qiu, H. X., & Chen, Q. (2009). [Values of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide in evaluation of cardiac function in children with congenital heart disease]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 11(6), 429-32.
Zhang SR, et al. [Values of Brain Natriuretic Peptide and N-terminal Pro-brain Natriuretic Peptide in Evaluation of Cardiac Function in Children With Congenital Heart Disease]. Zhongguo Dang Dai Er Ke Za Zhi. 2009;11(6):429-32. PubMed PMID: 19558803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Values of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide in evaluation of cardiac function in children with congenital heart disease]. AU - Zhang,Shen-Rong, AU - Zhang,Yuan-Hai, AU - Xu,Qiang, AU - Qiu,Hui-Xian, AU - Chen,Qi, PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2009/8/26/medline SP - 429 EP - 32 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 11 IS - 6 N2 - OBJECTIVE: To study the values of brain natriuretic peptide (BNP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in the evaluation of cardiac function in children with congenital heart disease (CHD). METHODS: Seventy-one children with CHD were classified to two groups: congestive heart failure (CHF) (n=23) and non-CHF (n=48). Thirty-five age-matched normal children were used as the control group. Plasma BNP content was measured using a microparticle enzyme immunoassay (MEIA) on the AxSYM. Plasma NT-proBNP content was measured using an automated electrochemiluminescence immunoassay on a Roche Modular Analytics E170 analyzer. Echocardiographic parameters, including left ventricular end diastolic dimension index (LVEDDI) and left ventricular ejection fraction (LVEF), were measured. RESULTS: Plasma BNP and NT-proBNP contents in the CHF group were significantly higher than those in the non-CHF group (P<0.01). The non-CHF group had higher plasma BNP and NT-proBNP contents than the control group (P<0.01). LogBNP and LogNT-proBNP values were negatively correlated with the LVEF in the CHF group (r=-0.64, r=-0.67 respectively, P<0.01), and they were positively correlated with the LVEDDI (r=0.58, r=0.76 respectively, P<0.01). In the non-CHF group, LogBNP and LogNT-proBNP values were not correlated with the LVEF, but a positive correlation was found between the LogNT-proBNP value and the LVEDDI (r=0.35, P<0.05). Using plasma BNP content > or =149.8 pg/mL and NT-proBNP content > or =820.1 pg/mL as cut-off values for diagnosing CHF respectively, the sensitivities were 87.0 % and 91.3% respectively, the specificities were 91.7% and 97.9% respectively, and the areas under the ROC curves were 0.935 and 0.987 respectively. CONCLUSIONS: Both BNP and NT-proBNP can be useful in assessment of cardiac function and diagnosis of CHF in children with CHD. NT-proBNP appears to be more sensitive and specific in the diagnosis of CHF than BNP. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/19558803/[Values_of_brain_natriuretic_peptide_and_N_terminal_pro_brain_natriuretic_peptide_in_evaluation_of_cardiac_function_in_children_with_congenital_heart_disease]_ L2 - http://www.zgddek.com/EN/abstract/abstract9724.shtml DB - PRIME DP - Unbound Medicine ER -