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Somatostatin, tau, and beta-amyloid within the anterior olfactory nucleus in Alzheimer disease.
Exp Neurol. 2010 Jun; 223(2):347-50.EN

Abstract

Impaired olfaction is an early symptom of Alzheimer disease (AD). This likely to reflect neurodegenerative processes taking place in basal telencephalic structures that mediate olfactory processing, including the anterior olfactory nucleus. Betaeta-amyloid (Abeta) accumulation in AD brain may relate to decline in somatostatin levels: somatostatin induces the expression of the Abeta-degrading enzyme neprilysin and somatostatin deficiency in AD may therefore reduce Abeta clearance. We have investigated the expression of somatostatin in the anterior olfactory nucleus of AD and control brain. We report that somatostatin levels were reduced by approximately 50% in AD brain. Furthermore, triple-immunofluorescence revealed co-localization of somatostatin expression with Abeta (65.43%) with Abeta and tau (19.75%) and with tau (2.47%). These data indicate that somatostatin decreases in AD and its expression may be linked with Abeta deposition.

Authors+Show Affiliations

Laboratorio de Neuroanatomía Humana, Departamento de Ciencias Médicas, Facultad de Medicina, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 02006 Albacete, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19559700

Citation

Saiz-Sanchez, D, et al. "Somatostatin, Tau, and Beta-amyloid Within the Anterior Olfactory Nucleus in Alzheimer Disease." Experimental Neurology, vol. 223, no. 2, 2010, pp. 347-50.
Saiz-Sanchez D, Ubeda-Bañon I, de la Rosa-Prieto C, et al. Somatostatin, tau, and beta-amyloid within the anterior olfactory nucleus in Alzheimer disease. Exp Neurol. 2010;223(2):347-50.
Saiz-Sanchez, D., Ubeda-Bañon, I., de la Rosa-Prieto, C., Argandoña-Palacios, L., Garcia-Muñozguren, S., Insausti, R., & Martinez-Marcos, A. (2010). Somatostatin, tau, and beta-amyloid within the anterior olfactory nucleus in Alzheimer disease. Experimental Neurology, 223(2), 347-50. https://doi.org/10.1016/j.expneurol.2009.06.010
Saiz-Sanchez D, et al. Somatostatin, Tau, and Beta-amyloid Within the Anterior Olfactory Nucleus in Alzheimer Disease. Exp Neurol. 2010;223(2):347-50. PubMed PMID: 19559700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Somatostatin, tau, and beta-amyloid within the anterior olfactory nucleus in Alzheimer disease. AU - Saiz-Sanchez,D, AU - Ubeda-Bañon,I, AU - de la Rosa-Prieto,C, AU - Argandoña-Palacios,L, AU - Garcia-Muñozguren,S, AU - Insausti,R, AU - Martinez-Marcos,A, Y1 - 2009/06/25/ PY - 2009/04/02/received PY - 2009/06/08/revised PY - 2009/06/17/accepted PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2010/7/2/medline SP - 347 EP - 50 JF - Experimental neurology JO - Exp. Neurol. VL - 223 IS - 2 N2 - Impaired olfaction is an early symptom of Alzheimer disease (AD). This likely to reflect neurodegenerative processes taking place in basal telencephalic structures that mediate olfactory processing, including the anterior olfactory nucleus. Betaeta-amyloid (Abeta) accumulation in AD brain may relate to decline in somatostatin levels: somatostatin induces the expression of the Abeta-degrading enzyme neprilysin and somatostatin deficiency in AD may therefore reduce Abeta clearance. We have investigated the expression of somatostatin in the anterior olfactory nucleus of AD and control brain. We report that somatostatin levels were reduced by approximately 50% in AD brain. Furthermore, triple-immunofluorescence revealed co-localization of somatostatin expression with Abeta (65.43%) with Abeta and tau (19.75%) and with tau (2.47%). These data indicate that somatostatin decreases in AD and its expression may be linked with Abeta deposition. SN - 1090-2430 UR - https://www.unboundmedicine.com/medline/citation/19559700/Somatostatin_tau_and_beta_amyloid_within_the_anterior_olfactory_nucleus_in_Alzheimer_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(09)00237-4 DB - PRIME DP - Unbound Medicine ER -