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Differential damage in the frontal cortex with aging, sporadic and familial Alzheimer's disease.
Brain Res Bull 2009; 80(4-5):196-202BR

Abstract

In order to understand relationships between executive and structural deficits in the frontal cortex of patients within normal aging or Alzheimer's disease, we studied frontal pathological changes in young and old controls compared to cases with sporadic (AD) or familial Alzheimer's disease (FAD). We performed a semi-automatic computer assisted analysis of the distribution of beta-amyloid (Abeta) deposits revealed by Abeta immunostaining as well as of neurofibrillary tangles (NFT) revealed by Gallyas silver staining in Brodman areas 10 (frontal polar), 12 (ventro-infero-median) and 24 (anterior cingular), using tissue samples from 5 FAD, 6 sporadic AD and 10 control brains. We also performed densitometric measurements of glial fibrillary acidic protein, principal compound of intermediate filaments of astrocytes, and of phosphorylated neurofilament H and M epitopes in areas 10 and 24. All regions studied seem almost completely spared in normal old controls, with only the oldest ones exhibiting a weak percentage of beta-amyloid deposit and hardly any NFT. On the contrary, all AD and FAD cases were severely damaged as shown by statistically significant increased percentages of beta-amyloid deposit, as well as by a high number of NFT. FAD cases (all from the same family) had statistically more beta-amyloid and GFAP than sporadic AD cases in both areas 10 and 24 and statistically more NFT only in area 24. The correlation between the percentage of beta-amyloid and the number of NFT was significant only for area 24. Altogether, these data suggest that the frontal cortex can be spared by AD type lesions in normal aging, but is severely damaged in sporadic and still more in familial Alzheimer's disease. The frontal regions appear to be differentially vulnerable, with area 12 having the less amyloid burden, area 24 the less NFT and area 10 having both more amyloid and more NFT. This pattern of damage in frontal regions may represent a strong neuroanatomical support for the deterioration of attention and cognitive capacities as well as for the presence of emotional and behavioral troubles in AD patients.

Authors+Show Affiliations

Department of Psychiatry, CHUV, Center for Psychiatric Neuroscience, Lausanne, Switzerland. Genevieve.Leuba@chuv.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19559767

Citation

Leuba, Geneviève, et al. "Differential Damage in the Frontal Cortex With Aging, Sporadic and Familial Alzheimer's Disease." Brain Research Bulletin, vol. 80, no. 4-5, 2009, pp. 196-202.
Leuba G, Vernay A, Zimmermann V, et al. Differential damage in the frontal cortex with aging, sporadic and familial Alzheimer's disease. Brain Res Bull. 2009;80(4-5):196-202.
Leuba, G., Vernay, A., Zimmermann, V., Saini, K., Kraftsik, R., & Savioz, A. (2009). Differential damage in the frontal cortex with aging, sporadic and familial Alzheimer's disease. Brain Research Bulletin, 80(4-5), pp. 196-202. doi:10.1016/j.brainresbull.2009.06.009.
Leuba G, et al. Differential Damage in the Frontal Cortex With Aging, Sporadic and Familial Alzheimer's Disease. Brain Res Bull. 2009 Oct 28;80(4-5):196-202. PubMed PMID: 19559767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential damage in the frontal cortex with aging, sporadic and familial Alzheimer's disease. AU - Leuba,Geneviève, AU - Vernay,André, AU - Zimmermann,Vincent, AU - Saini,Krishan, AU - Kraftsik,Rudolf, AU - Savioz,Armand, Y1 - 2009/06/25/ PY - 2009/05/11/received PY - 2009/06/17/revised PY - 2009/06/18/accepted PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2009/11/18/medline SP - 196 EP - 202 JF - Brain research bulletin JO - Brain Res. Bull. VL - 80 IS - 4-5 N2 - In order to understand relationships between executive and structural deficits in the frontal cortex of patients within normal aging or Alzheimer's disease, we studied frontal pathological changes in young and old controls compared to cases with sporadic (AD) or familial Alzheimer's disease (FAD). We performed a semi-automatic computer assisted analysis of the distribution of beta-amyloid (Abeta) deposits revealed by Abeta immunostaining as well as of neurofibrillary tangles (NFT) revealed by Gallyas silver staining in Brodman areas 10 (frontal polar), 12 (ventro-infero-median) and 24 (anterior cingular), using tissue samples from 5 FAD, 6 sporadic AD and 10 control brains. We also performed densitometric measurements of glial fibrillary acidic protein, principal compound of intermediate filaments of astrocytes, and of phosphorylated neurofilament H and M epitopes in areas 10 and 24. All regions studied seem almost completely spared in normal old controls, with only the oldest ones exhibiting a weak percentage of beta-amyloid deposit and hardly any NFT. On the contrary, all AD and FAD cases were severely damaged as shown by statistically significant increased percentages of beta-amyloid deposit, as well as by a high number of NFT. FAD cases (all from the same family) had statistically more beta-amyloid and GFAP than sporadic AD cases in both areas 10 and 24 and statistically more NFT only in area 24. The correlation between the percentage of beta-amyloid and the number of NFT was significant only for area 24. Altogether, these data suggest that the frontal cortex can be spared by AD type lesions in normal aging, but is severely damaged in sporadic and still more in familial Alzheimer's disease. The frontal regions appear to be differentially vulnerable, with area 12 having the less amyloid burden, area 24 the less NFT and area 10 having both more amyloid and more NFT. This pattern of damage in frontal regions may represent a strong neuroanatomical support for the deterioration of attention and cognitive capacities as well as for the presence of emotional and behavioral troubles in AD patients. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/19559767/Differential_damage_in_the_frontal_cortex_with_aging_sporadic_and_familial_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(09)00192-0 DB - PRIME DP - Unbound Medicine ER -