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Effectiveness of honey on Staphylococcus aureus and Pseudomonas aeruginosa biofilms.
Otolaryngol Head Neck Surg. 2009 Jul; 141(1):114-8.OH

Abstract

OBJECTIVES

Biofilms formed by Pseudomonas aeruginosa (PA) and Staphylococcus aureus (SA) have been shown to be an important factor in the pathophysiology of chronic rhinosinusitis (CRS). As well, honey has been used as an effective topical antimicrobial agent for years. Our objective is to determine the in vitro effect of honey against biofilms produced by PA and SA.

STUDY DESIGN

In vitro testing of honey against bacterial biofilms.

METHODS

We used a previously established biofilm model to assess antibacterial activity of honey against 11 methicillin-susceptible SA (MSSA), 11 methicillin-resistant SA (MRSA), and 11 PA isolates. Honeys were tested against both planktonic and biofilm-grown bacteria.

RESULTS

Honey was effective in killing 100 percent of the isolates in the planktonic form. The bactericidal rates for the Sidr and Manuka honeys against MSSA, MRSA, and PA biofilms were 63-82 percent, 73-63 percent, and 91-91 percent, respectively. These rates were significantly higher (P<0.001) than those seen with single antibiotics commonly used against SA.

CONCLUSION

Honey, which is a natural, nontoxic, and inexpensive product, is effective in killing SA and PA bacterial biofilms. This intriguing observation may have important clinical implications and could lead to a new approach for treating refractory CRS.

Authors+Show Affiliations

Department of Otolaryngology, University of Ottawa, and Childrens Hospital of Eastern Ontario, Ottawa, Ontario, Canada. dr_talloo@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19559969

Citation

Alandejani, Talal, et al. "Effectiveness of Honey On Staphylococcus Aureus and Pseudomonas Aeruginosa Biofilms." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 141, no. 1, 2009, pp. 114-8.
Alandejani T, Marsan J, Ferris W, et al. Effectiveness of honey on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Otolaryngol Head Neck Surg. 2009;141(1):114-8.
Alandejani, T., Marsan, J., Ferris, W., Slinger, R., & Chan, F. (2009). Effectiveness of honey on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 141(1), 114-8. https://doi.org/10.1016/j.otohns.2009.01.005
Alandejani T, et al. Effectiveness of Honey On Staphylococcus Aureus and Pseudomonas Aeruginosa Biofilms. Otolaryngol Head Neck Surg. 2009;141(1):114-8. PubMed PMID: 19559969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of honey on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. AU - Alandejani,Talal, AU - Marsan,Joseph, AU - Ferris,Wendy, AU - Slinger,Robert, AU - Chan,Frank, Y1 - 2009/03/09/ PY - 2008/09/02/received PY - 2009/01/07/revised PY - 2009/01/07/accepted PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2009/9/18/medline SP - 114 EP - 8 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 141 IS - 1 N2 - OBJECTIVES: Biofilms formed by Pseudomonas aeruginosa (PA) and Staphylococcus aureus (SA) have been shown to be an important factor in the pathophysiology of chronic rhinosinusitis (CRS). As well, honey has been used as an effective topical antimicrobial agent for years. Our objective is to determine the in vitro effect of honey against biofilms produced by PA and SA. STUDY DESIGN: In vitro testing of honey against bacterial biofilms. METHODS: We used a previously established biofilm model to assess antibacterial activity of honey against 11 methicillin-susceptible SA (MSSA), 11 methicillin-resistant SA (MRSA), and 11 PA isolates. Honeys were tested against both planktonic and biofilm-grown bacteria. RESULTS: Honey was effective in killing 100 percent of the isolates in the planktonic form. The bactericidal rates for the Sidr and Manuka honeys against MSSA, MRSA, and PA biofilms were 63-82 percent, 73-63 percent, and 91-91 percent, respectively. These rates were significantly higher (P<0.001) than those seen with single antibiotics commonly used against SA. CONCLUSION: Honey, which is a natural, nontoxic, and inexpensive product, is effective in killing SA and PA bacterial biofilms. This intriguing observation may have important clinical implications and could lead to a new approach for treating refractory CRS. SN - 0194-5998 UR - https://www.unboundmedicine.com/medline/citation/19559969/Effectiveness_of_honey_on_Staphylococcus_aureus_and_Pseudomonas_aeruginosa_biofilms_ L2 - https://journals.sagepub.com/doi/10.1016/j.otohns.2009.01.005?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -