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Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis.

Abstract

BACKGROUND/AIMS

Non-alcoholic fatty liver disease (NAFLD) and chronic plaque psoriasis are both associated with metabolic syndrome and increased risk of incident cardiovascular disease. We assessed the frequency and characteristics of NAFLD in patients with chronic plaque psoriasis.

METHODS

One hundred and thirty consecutive patients with chronic plaque psoriasis and 260 apparently healthy controls matched for age, sex and body mass index were enrolled. NAFLD was diagnosed by abdominal ultrasound after excluding other secondary causes of chronic liver disease.

RESULTS

The frequency of NAFLD was remarkably greater in psoriasis patients than in controls (47% vs. 28%; p<0.0001). Patients with psoriasis and NAFLD (n=61) were more likely to have metabolic syndrome and had higher serum C-reactive protein concentrations and greater severity of psoriasis according to the Psoriasis Area and Severity Index (PASI) score (14.2+/-12.6 vs. 9.6+/-7.4; p<0.01) than those with psoriasis alone (n=69). In a subgroup of psoriasis patients (n=43), those with NAFLD (n=21) also had significantly higher serum interleukin-6 and lower serum adiponectin levels. Notably, in multivariate regression analysis, NAFLD was associated with higher PASI score independently of age, gender, body mass index, psoriasis duration, and alcohol consumption.

CONCLUSIONS

NAFLD is frequent in patients with chronic plaque psoriasis - affecting up to nearly half of these patients - and is strongly associated with psoriasis severity. Early recognition of NAFLD by radiological imaging tests in this group of patients is warranted.

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  • Authors+Show Affiliations

    ,

    Section of Dermatology, Department of Biomedical and Surgical Science, University of Verona, Piazzale A. Stefani 1, 37126 Verona, Italy. paolo.gisondi@univr.it

    , ,

    Source

    Journal of hepatology 51:4 2009 Oct pg 758-64

    MeSH

    Adiponectin
    Adult
    C-Reactive Protein
    Case-Control Studies
    Chronic Disease
    Cross-Sectional Studies
    Fatty Liver
    Female
    Humans
    Interleukin-6
    Italy
    Male
    Metabolic Syndrome
    Middle Aged
    Psoriasis

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19560226

    Citation

    Gisondi, Paolo, et al. "Non-alcoholic Fatty Liver Disease in Patients With Chronic Plaque Psoriasis." Journal of Hepatology, vol. 51, no. 4, 2009, pp. 758-64.
    Gisondi P, Targher G, Zoppini G, et al. Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. J Hepatol. 2009;51(4):758-64.
    Gisondi, P., Targher, G., Zoppini, G., & Girolomoni, G. (2009). Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. Journal of Hepatology, 51(4), pp. 758-64. doi:10.1016/j.jhep.2009.04.020.
    Gisondi P, et al. Non-alcoholic Fatty Liver Disease in Patients With Chronic Plaque Psoriasis. J Hepatol. 2009;51(4):758-64. PubMed PMID: 19560226.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. AU - Gisondi,Paolo, AU - Targher,Giovanni, AU - Zoppini,Giacomo, AU - Girolomoni,Giampiero, Y1 - 2009/05/27/ PY - 2009/02/11/received PY - 2009/04/27/revised PY - 2009/04/29/accepted PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2009/12/30/medline SP - 758 EP - 64 JF - Journal of hepatology JO - J. Hepatol. VL - 51 IS - 4 N2 - BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) and chronic plaque psoriasis are both associated with metabolic syndrome and increased risk of incident cardiovascular disease. We assessed the frequency and characteristics of NAFLD in patients with chronic plaque psoriasis. METHODS: One hundred and thirty consecutive patients with chronic plaque psoriasis and 260 apparently healthy controls matched for age, sex and body mass index were enrolled. NAFLD was diagnosed by abdominal ultrasound after excluding other secondary causes of chronic liver disease. RESULTS: The frequency of NAFLD was remarkably greater in psoriasis patients than in controls (47% vs. 28%; p<0.0001). Patients with psoriasis and NAFLD (n=61) were more likely to have metabolic syndrome and had higher serum C-reactive protein concentrations and greater severity of psoriasis according to the Psoriasis Area and Severity Index (PASI) score (14.2+/-12.6 vs. 9.6+/-7.4; p<0.01) than those with psoriasis alone (n=69). In a subgroup of psoriasis patients (n=43), those with NAFLD (n=21) also had significantly higher serum interleukin-6 and lower serum adiponectin levels. Notably, in multivariate regression analysis, NAFLD was associated with higher PASI score independently of age, gender, body mass index, psoriasis duration, and alcohol consumption. CONCLUSIONS: NAFLD is frequent in patients with chronic plaque psoriasis - affecting up to nearly half of these patients - and is strongly associated with psoriasis severity. Early recognition of NAFLD by radiological imaging tests in this group of patients is warranted. SN - 1600-0641 UR - https://www.unboundmedicine.com/medline/citation/19560226/Non_alcoholic_fatty_liver_disease_in_patients_with_chronic_plaque_psoriasis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(09)00364-X DB - PRIME DP - Unbound Medicine ER -