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Breast feeding, parental allergy and asthma in children followed for 8 years. The PIAMA birth cohort study.
Thorax. 2009 Jul; 64(7):604-9.T

Abstract

BACKGROUND

It is unclear how the association between breast feeding and asthma develops with age of the child and how this association over time is influenced by maternal or paternal allergy. These factors--the age of the child and maternal or paternal allergy--might partly explain the conflicting results observed in cross-sectional studies.

METHODS

The study population consisted of 3115 Dutch children born in 1996/1997 who participated in the PIAMA (Prevention and Incidence of Asthma and Mite Allergy) birth cohort study. Data on breast feeding and asthma (based on wheeze, dyspnoea and prescription of inhaled steroids) were collected by yearly questionnaires. At 8 years, specific immunoglobulin E (IgE) to airborne allergens and bronchial responsiveness were measured. Data were analysed by logistic regression and generalised estimating equations (GEEs), and stratified by maternal and paternal allergic status.

RESULTS

35% (n = 1081) of the children were breast fed for >16 weeks. At 8 years of age, 12.6% (n = 392) had asthma. Breast feeding (>16 weeks vs no breast feeding) was significantly associated with a lower asthma prevalence from 3 to 8 years of age, in children of both non-allergic and allergic mothers. The inverse association between breast feeding and sensitisation to airborne allergens at 8 years was non-significant. Breast feeding was not associated with bronchial hyper-responsiveness. No interaction between breast feeding and gender, maternal allergy or paternal allergy was observed in any of the associations.

CONCLUSIONS

Breast feeding is associated with a lower asthma risk in children until 8 years of age without evidence of attenuation and regardless of the family history of allergy.

Authors+Show Affiliations

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. salome.scholtens@rivm.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19561280

Citation

Scholtens, S, et al. "Breast Feeding, Parental Allergy and Asthma in Children Followed for 8 Years. the PIAMA Birth Cohort Study." Thorax, vol. 64, no. 7, 2009, pp. 604-9.
Scholtens S, Wijga AH, Brunekreef B, et al. Breast feeding, parental allergy and asthma in children followed for 8 years. The PIAMA birth cohort study. Thorax. 2009;64(7):604-9.
Scholtens, S., Wijga, A. H., Brunekreef, B., Kerkhof, M., Hoekstra, M. O., Gerritsen, J., Aalberse, R., de Jongste, J. C., & Smit, H. A. (2009). Breast feeding, parental allergy and asthma in children followed for 8 years. The PIAMA birth cohort study. Thorax, 64(7), 604-9. https://doi.org/10.1136/thx.2007.094938
Scholtens S, et al. Breast Feeding, Parental Allergy and Asthma in Children Followed for 8 Years. the PIAMA Birth Cohort Study. Thorax. 2009;64(7):604-9. PubMed PMID: 19561280.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast feeding, parental allergy and asthma in children followed for 8 years. The PIAMA birth cohort study. AU - Scholtens,S, AU - Wijga,A H, AU - Brunekreef,B, AU - Kerkhof,M, AU - Hoekstra,M O, AU - Gerritsen,J, AU - Aalberse,R, AU - de Jongste,J C, AU - Smit,H A, PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2009/8/8/medline SP - 604 EP - 9 JF - Thorax JO - Thorax VL - 64 IS - 7 N2 - BACKGROUND: It is unclear how the association between breast feeding and asthma develops with age of the child and how this association over time is influenced by maternal or paternal allergy. These factors--the age of the child and maternal or paternal allergy--might partly explain the conflicting results observed in cross-sectional studies. METHODS: The study population consisted of 3115 Dutch children born in 1996/1997 who participated in the PIAMA (Prevention and Incidence of Asthma and Mite Allergy) birth cohort study. Data on breast feeding and asthma (based on wheeze, dyspnoea and prescription of inhaled steroids) were collected by yearly questionnaires. At 8 years, specific immunoglobulin E (IgE) to airborne allergens and bronchial responsiveness were measured. Data were analysed by logistic regression and generalised estimating equations (GEEs), and stratified by maternal and paternal allergic status. RESULTS: 35% (n = 1081) of the children were breast fed for >16 weeks. At 8 years of age, 12.6% (n = 392) had asthma. Breast feeding (>16 weeks vs no breast feeding) was significantly associated with a lower asthma prevalence from 3 to 8 years of age, in children of both non-allergic and allergic mothers. The inverse association between breast feeding and sensitisation to airborne allergens at 8 years was non-significant. Breast feeding was not associated with bronchial hyper-responsiveness. No interaction between breast feeding and gender, maternal allergy or paternal allergy was observed in any of the associations. CONCLUSIONS: Breast feeding is associated with a lower asthma risk in children until 8 years of age without evidence of attenuation and regardless of the family history of allergy. SN - 1468-3296 UR - https://www.unboundmedicine.com/medline/citation/19561280/Breast_feeding_parental_allergy_and_asthma_in_children_followed_for_8_years__The_PIAMA_birth_cohort_study_ L2 - https://thorax.bmj.com/lookup/pmidlookup?view=long&pmid=19561280 DB - PRIME DP - Unbound Medicine ER -