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Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health study.

Abstract

BACKGROUND

Previous research relating dietary fat, a modifiable risk factor, to pancreatic cancer has been inconclusive.

METHODS

We prospectively analyzed the association between intakes of fat, fat subtypes, and fat food sources and exocrine pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study, a US cohort of 308 736 men and 216 737 women who completed a 124-item food frequency questionnaire in 1995-1996. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models, with adjustment for energy intake, smoking history, body mass index, and diabetes. Statistical tests were two-sided.

RESULTS

Over an average follow-up of 6.3 years, 865 men and 472 women were diagnosed with exocrine pancreatic cancer (45.0 and 34.5 cases per 100 000 person-years, respectively). After multivariable adjustment and combination of data for men and women, pancreatic cancer risk was directly related to the intakes of total fat (highest vs lowest quintile, 46.8 vs 33.2 cases per 100 000 person-years, HR = 1.23, 95% CI = 1.03 to 1.46; P(trend) = .03), saturated fat (51.5 vs 33.1 cases per 100 000 person-years, HR = 1.36, 95% CI = 1.14 to 1.62; P(trend) < .001), and monounsaturated fat (46.2 vs 32.9 cases per 100 000 person-years, HR = 1.22, 95% CI = 1.02 to 1.46; P(trend) = .05) but not polyunsaturated fat. The associations were strongest for saturated fat from animal food sources (52.0 vs 32.2 cases per 100 000 person-years, HR = 1.43, 95% CI = 1.20 to 1.70; P(trend) < .001); specifically, intakes from red meat and dairy products were both statistically significantly associated with increased pancreatic cancer risk (HR = 1.27 and 1.19, respectively).

CONCLUSION

In this large prospective cohort with a wide range of intakes, dietary fat of animal origin was associated with increased pancreatic cancer risk.

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  • Authors+Show Affiliations

    ,

    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA.

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    Source

    Journal of the National Cancer Institute 101:14 2009 Jul 15 pg 1001-11

    MeSH

    Aged
    Animals
    Cattle
    Dairy Products
    Diet Surveys
    Dietary Fats
    Fatty Acids
    Feeding Behavior
    Female
    Humans
    Male
    Meat
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Pancreatic Neoplasms
    Proportional Hazards Models
    Prospective Studies
    Research Design
    Surveys and Questionnaires
    Swine

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Intramural

    Language

    eng

    PubMed ID

    19561318

    Citation

    Thiébaut, Anne C M., et al. "Dietary Fatty Acids and Pancreatic Cancer in the NIH-AARP Diet and Health Study." Journal of the National Cancer Institute, vol. 101, no. 14, 2009, pp. 1001-11.
    Thiébaut AC, Jiao L, Silverman DT, et al. Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health study. J Natl Cancer Inst. 2009;101(14):1001-11.
    Thiébaut, A. C., Jiao, L., Silverman, D. T., Cross, A. J., Thompson, F. E., Subar, A. F., ... Stolzenberg-Solomon, R. Z. (2009). Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health study. Journal of the National Cancer Institute, 101(14), pp. 1001-11. doi:10.1093/jnci/djp168.
    Thiébaut AC, et al. Dietary Fatty Acids and Pancreatic Cancer in the NIH-AARP Diet and Health Study. J Natl Cancer Inst. 2009 Jul 15;101(14):1001-11. PubMed PMID: 19561318.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary fatty acids and pancreatic cancer in the NIH-AARP diet and health study. AU - Thiébaut,Anne C M, AU - Jiao,Li, AU - Silverman,Debra T, AU - Cross,Amanda J, AU - Thompson,Frances E, AU - Subar,Amy F, AU - Hollenbeck,Albert R, AU - Schatzkin,Arthur, AU - Stolzenberg-Solomon,Rachael Z, Y1 - 2009/06/26/ PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2009/7/28/medline SP - 1001 EP - 11 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 101 IS - 14 N2 - BACKGROUND: Previous research relating dietary fat, a modifiable risk factor, to pancreatic cancer has been inconclusive. METHODS: We prospectively analyzed the association between intakes of fat, fat subtypes, and fat food sources and exocrine pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study, a US cohort of 308 736 men and 216 737 women who completed a 124-item food frequency questionnaire in 1995-1996. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models, with adjustment for energy intake, smoking history, body mass index, and diabetes. Statistical tests were two-sided. RESULTS: Over an average follow-up of 6.3 years, 865 men and 472 women were diagnosed with exocrine pancreatic cancer (45.0 and 34.5 cases per 100 000 person-years, respectively). After multivariable adjustment and combination of data for men and women, pancreatic cancer risk was directly related to the intakes of total fat (highest vs lowest quintile, 46.8 vs 33.2 cases per 100 000 person-years, HR = 1.23, 95% CI = 1.03 to 1.46; P(trend) = .03), saturated fat (51.5 vs 33.1 cases per 100 000 person-years, HR = 1.36, 95% CI = 1.14 to 1.62; P(trend) < .001), and monounsaturated fat (46.2 vs 32.9 cases per 100 000 person-years, HR = 1.22, 95% CI = 1.02 to 1.46; P(trend) = .05) but not polyunsaturated fat. The associations were strongest for saturated fat from animal food sources (52.0 vs 32.2 cases per 100 000 person-years, HR = 1.43, 95% CI = 1.20 to 1.70; P(trend) < .001); specifically, intakes from red meat and dairy products were both statistically significantly associated with increased pancreatic cancer risk (HR = 1.27 and 1.19, respectively). CONCLUSION: In this large prospective cohort with a wide range of intakes, dietary fat of animal origin was associated with increased pancreatic cancer risk. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/19561318/Dietary_fatty_acids_and_pancreatic_cancer_in_the_NIH_AARP_diet_and_health_study_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djp168 DB - PRIME DP - Unbound Medicine ER -