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Anthropometric assessment of abdominal obesity and coronary heart disease risk in men: the PRIME study.
Heart 2010; 96(2):136-40H

Abstract

OBJECTIVE

Waist-to-height ratio is an anthropometric indicator of abdominal obesity that accounts for stature. Earlier studies have reported marked associations between the waist-to-height ratio and cardiovascular risk factors. The goal of this study was to compare the associations of waist-to-height ratio, waist girth, waist-to-hip ratio or body mass index (BMI) with incidence of coronary events.

DESIGN

Prospective study with 10 602 men, aged 50-59 years, recruited between 1991 and 1993 in three centres in France and one centre in Northern Ireland. Clinical and biological data were obtained at interview by trained staff. During the 10 years of follow-up 659 incident coronary events (CHD) were recorded. The relations between anthropometric markers and coronary events were estimated by Cox proportional hazards models.

RESULTS

Waist circumference, waist-to-hip ratio, waist-to-height ratios and BMI were positively associated with blood pressure (p<0.0001), diabetes (p<0.0001), low-density lipoprotein (LDL)-cholesterol (p<0.0001), triglycerides (p<0.0001) and inversely correlated to high-density lipoprotein (HDL)-cholesterol (p<0.0001). There was a linear association between waist circumference, waist-to-hip ratio, waist-to-height ratio, BMI and CHD events. The age-adjusted and centre-adjusted relative risks (95% CI) for CHD were 1.57 (1.22 to 2.01), 1.75 (1.34 to 2.87), 2.3 (1.79 to 2.99) and 1.99 (1.54 to 2.56) in the 5th quintile vs the first quintile of waist circumference, waist-to-hip ratio, waist-to-height ratio and BMI distribution, respectively. After further adjustment for school duration, physical activity, tobacco and alcohol consumption, hypertension, diabetes, HDL-cholesterol and triglycerides, the relative risks for CHD were 0.99 (0.76 to 1.30) for waist circumference (p = 0.5), 1.22 (0.93 to 1.60) for waist-to-hip ratio (p = 0.1), 1.53 (1.16 to 2.01) for waist-to-height ratio (p = 0.03) and 1.30 (0.99 to 1.71) for BMI (p = 0.06).

CONCLUSION

In middle-aged European men, waist-to-height ratio identifies coronary risk more strongly than waist circumference, waist-to-hip ratio or BMI, though the difference is marginal.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19561364

Citation

Gruson, E, et al. "Anthropometric Assessment of Abdominal Obesity and Coronary Heart Disease Risk in Men: the PRIME Study." Heart (British Cardiac Society), vol. 96, no. 2, 2010, pp. 136-40.
Gruson E, Montaye M, Kee F, et al. Anthropometric assessment of abdominal obesity and coronary heart disease risk in men: the PRIME study. Heart. 2010;96(2):136-40.
Gruson, E., Montaye, M., Kee, F., Wagner, A., Bingham, A., Ruidavets, J. B., ... Dallongeville, J. (2010). Anthropometric assessment of abdominal obesity and coronary heart disease risk in men: the PRIME study. Heart (British Cardiac Society), 96(2), pp. 136-40. doi:10.1136/hrt.2009.171447.
Gruson E, et al. Anthropometric Assessment of Abdominal Obesity and Coronary Heart Disease Risk in Men: the PRIME Study. Heart. 2010;96(2):136-40. PubMed PMID: 19561364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthropometric assessment of abdominal obesity and coronary heart disease risk in men: the PRIME study. AU - Gruson,E, AU - Montaye,M, AU - Kee,F, AU - Wagner,A, AU - Bingham,A, AU - Ruidavets,J-B, AU - Haas,B, AU - Evans,A, AU - Ferrières,J, AU - Ducimetière,P P, AU - Amouyel,P, AU - Dallongeville,J, Y1 - 2009/06/28/ PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2010/3/26/medline SP - 136 EP - 40 JF - Heart (British Cardiac Society) JO - Heart VL - 96 IS - 2 N2 - OBJECTIVE: Waist-to-height ratio is an anthropometric indicator of abdominal obesity that accounts for stature. Earlier studies have reported marked associations between the waist-to-height ratio and cardiovascular risk factors. The goal of this study was to compare the associations of waist-to-height ratio, waist girth, waist-to-hip ratio or body mass index (BMI) with incidence of coronary events. DESIGN: Prospective study with 10 602 men, aged 50-59 years, recruited between 1991 and 1993 in three centres in France and one centre in Northern Ireland. Clinical and biological data were obtained at interview by trained staff. During the 10 years of follow-up 659 incident coronary events (CHD) were recorded. The relations between anthropometric markers and coronary events were estimated by Cox proportional hazards models. RESULTS: Waist circumference, waist-to-hip ratio, waist-to-height ratios and BMI were positively associated with blood pressure (p<0.0001), diabetes (p<0.0001), low-density lipoprotein (LDL)-cholesterol (p<0.0001), triglycerides (p<0.0001) and inversely correlated to high-density lipoprotein (HDL)-cholesterol (p<0.0001). There was a linear association between waist circumference, waist-to-hip ratio, waist-to-height ratio, BMI and CHD events. The age-adjusted and centre-adjusted relative risks (95% CI) for CHD were 1.57 (1.22 to 2.01), 1.75 (1.34 to 2.87), 2.3 (1.79 to 2.99) and 1.99 (1.54 to 2.56) in the 5th quintile vs the first quintile of waist circumference, waist-to-hip ratio, waist-to-height ratio and BMI distribution, respectively. After further adjustment for school duration, physical activity, tobacco and alcohol consumption, hypertension, diabetes, HDL-cholesterol and triglycerides, the relative risks for CHD were 0.99 (0.76 to 1.30) for waist circumference (p = 0.5), 1.22 (0.93 to 1.60) for waist-to-hip ratio (p = 0.1), 1.53 (1.16 to 2.01) for waist-to-height ratio (p = 0.03) and 1.30 (0.99 to 1.71) for BMI (p = 0.06). CONCLUSION: In middle-aged European men, waist-to-height ratio identifies coronary risk more strongly than waist circumference, waist-to-hip ratio or BMI, though the difference is marginal. SN - 1468-201X UR - https://www.unboundmedicine.com/medline/citation/19561364/Anthropometric_assessment_of_abdominal_obesity_and_coronary_heart_disease_risk_in_men:_the_PRIME_study_ L2 - http://heart.bmj.com/cgi/pmidlookup?view=long&amp;pmid=19561364 DB - PRIME DP - Unbound Medicine ER -