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Comparison of clinicoradiologic manifestation of nonspecific interstitial pneumonia and usual interstitial pneumonia/idiopathic pulmonary fibrosis: a report from NRITLD.
Ann Thorac Med. 2008 Oct; 3(4):140-5.AT

Abstract

BACKGROUND

Ever since Katzenstein and Fiorelli introduced the term nonspecific interstitial pneumonia (NSIP) to denote those cases of interstitial pneumonia that cannot be categorized as any of the other types of idiopathic interstitial pneumonias (IIP), there has been continuing debate on whether it is a real clinical entity or not. The American Thoracic Society/European Respiratory Symposium task group tried to identify idiopathic NSIP as a separate disease and exclude it from the category of IIP. However, it appears that the clinical presentation of NSIP and usual interstitial pneumonia (UIP) are the same.

OBJECTIVE

To show that the radiologic features of NSIP and UIP should be relied upon, instead of clinical presentation and pathologic findings, to differentiate between the two.

MATERIALS AND METHODS

Consecutive patients who had received a diagnosis of either NSIP or UIP on the basis of open lung biopsy between January 2001 and December 2007 were identified for inclusion in this retrospective review. The study included 61 subjects: 32 men and 29 women with a mean age of 59.39 +/- 14.5 years. Chest computed tomography images of all the cases were collected for a review. High resolution computed tomography (HRCT) and all pathologic specimens were also evaluated. A weighted kappa coefficient was used to evaluate whether radiology can be used instead of biopsy for the diagnosis of NSIP and UIP. Comparison of the mean ages and the time intervals (i.e., interval between symptom onset and the time of diagnosis) in the UIP and NSIP groups was done using the Mann-Whitney U test. Association between gender and biopsy result was evaluated by the Fisher exact test. Data were evaluated using SPSS, v.13.

RESULTS

Sixty-one patients were included in this study, 32 were male and 29 were female. On the basis of biopsy findings, 50 (82%) patients had UIP and 11 (18%) had NSIP. Thirty (60%) of the 50 patients who had UIP were male and 20 (40%) were female; 2 (18.2%) of the 11 patients who suffered from NSIP were male and 9 (81.8%) were female. Based on HRCT findings, 36 (60%) patients were diagnosed to have UIP and 24 (40%) were diagnosed with NSIP. When diagnosis was based on biopsy findings, the time interval in the UIP group was 13.59 +/- 8.29 months and in the NSIP group it was 7.90 +/- 4.18 months. When diagnosed on the basis of HRCT findings, the time interval in the UIP group was 14.22 +/- 8.94 months and in the NSIP group it was 10.54 +/- 5.78 months. When diagnosis was on the basis of biopsy, the mean age in the UIP group was 61.30 +/- 14.18 years and in the NSIP group it was 50.73 +/- 13.14 years.

CONCLUSION

HRCT can be used instead of invasive methods like lung biopsy to differentiate between UIP and NSIP.

Authors+Show Affiliations

Department of Internal Medicine, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences and Health Services MC, Shaheed Bahonar Ave., Darabad, Tehran 19569, P.O: 19575/154, Iran. saeid_ftafti@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19561896

Citation

Tafti, Saeid Fallah, et al. "Comparison of Clinicoradiologic Manifestation of Nonspecific Interstitial Pneumonia and Usual Interstitial Pneumonia/idiopathic Pulmonary Fibrosis: a Report From NRITLD." Annals of Thoracic Medicine, vol. 3, no. 4, 2008, pp. 140-5.
Tafti SF, Mokri B, Mohammadi F, et al. Comparison of clinicoradiologic manifestation of nonspecific interstitial pneumonia and usual interstitial pneumonia/idiopathic pulmonary fibrosis: a report from NRITLD. Ann Thorac Med. 2008;3(4):140-5.
Tafti, S. F., Mokri, B., Mohammadi, F., Bakhshayesh-Karam, M., Emami, H., & Masjedi, M. R. (2008). Comparison of clinicoradiologic manifestation of nonspecific interstitial pneumonia and usual interstitial pneumonia/idiopathic pulmonary fibrosis: a report from NRITLD. Annals of Thoracic Medicine, 3(4), 140-5. https://doi.org/10.4103/1817-1737.43081
Tafti SF, et al. Comparison of Clinicoradiologic Manifestation of Nonspecific Interstitial Pneumonia and Usual Interstitial Pneumonia/idiopathic Pulmonary Fibrosis: a Report From NRITLD. Ann Thorac Med. 2008;3(4):140-5. PubMed PMID: 19561896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of clinicoradiologic manifestation of nonspecific interstitial pneumonia and usual interstitial pneumonia/idiopathic pulmonary fibrosis: a report from NRITLD. AU - Tafti,Saeid Fallah, AU - Mokri,Bahareh, AU - Mohammadi,Foroozan, AU - Bakhshayesh-Karam,Mehrdad, AU - Emami,Habib, AU - Masjedi,Mohammad Reza, PY - 2008/04/19/received PY - 2008/06/15/accepted PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2009/6/30/medline KW - Interstitial lung diseases KW - X-ray KW - computed KW - pneumonitis KW - tomography SP - 140 EP - 5 JF - Annals of thoracic medicine JO - Ann Thorac Med VL - 3 IS - 4 N2 - BACKGROUND: Ever since Katzenstein and Fiorelli introduced the term nonspecific interstitial pneumonia (NSIP) to denote those cases of interstitial pneumonia that cannot be categorized as any of the other types of idiopathic interstitial pneumonias (IIP), there has been continuing debate on whether it is a real clinical entity or not. The American Thoracic Society/European Respiratory Symposium task group tried to identify idiopathic NSIP as a separate disease and exclude it from the category of IIP. However, it appears that the clinical presentation of NSIP and usual interstitial pneumonia (UIP) are the same. OBJECTIVE: To show that the radiologic features of NSIP and UIP should be relied upon, instead of clinical presentation and pathologic findings, to differentiate between the two. MATERIALS AND METHODS: Consecutive patients who had received a diagnosis of either NSIP or UIP on the basis of open lung biopsy between January 2001 and December 2007 were identified for inclusion in this retrospective review. The study included 61 subjects: 32 men and 29 women with a mean age of 59.39 +/- 14.5 years. Chest computed tomography images of all the cases were collected for a review. High resolution computed tomography (HRCT) and all pathologic specimens were also evaluated. A weighted kappa coefficient was used to evaluate whether radiology can be used instead of biopsy for the diagnosis of NSIP and UIP. Comparison of the mean ages and the time intervals (i.e., interval between symptom onset and the time of diagnosis) in the UIP and NSIP groups was done using the Mann-Whitney U test. Association between gender and biopsy result was evaluated by the Fisher exact test. Data were evaluated using SPSS, v.13. RESULTS: Sixty-one patients were included in this study, 32 were male and 29 were female. On the basis of biopsy findings, 50 (82%) patients had UIP and 11 (18%) had NSIP. Thirty (60%) of the 50 patients who had UIP were male and 20 (40%) were female; 2 (18.2%) of the 11 patients who suffered from NSIP were male and 9 (81.8%) were female. Based on HRCT findings, 36 (60%) patients were diagnosed to have UIP and 24 (40%) were diagnosed with NSIP. When diagnosis was based on biopsy findings, the time interval in the UIP group was 13.59 +/- 8.29 months and in the NSIP group it was 7.90 +/- 4.18 months. When diagnosed on the basis of HRCT findings, the time interval in the UIP group was 14.22 +/- 8.94 months and in the NSIP group it was 10.54 +/- 5.78 months. When diagnosis was on the basis of biopsy, the mean age in the UIP group was 61.30 +/- 14.18 years and in the NSIP group it was 50.73 +/- 13.14 years. CONCLUSION: HRCT can be used instead of invasive methods like lung biopsy to differentiate between UIP and NSIP. SN - 1817-1737 UR - https://www.unboundmedicine.com/medline/citation/19561896/Comparison_of_clinicoradiologic_manifestation_of_nonspecific_interstitial_pneumonia_and_usual_interstitial_pneumonia/idiopathic_pulmonary_fibrosis:_a_report_from_NRITLD_ L2 - http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2008;volume=3;issue=4;spage=140;epage=145;aulast=Tafti DB - PRIME DP - Unbound Medicine ER -
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