TY - JOUR T1 - Studies on the effect of water-soluble polymers on drug-cyclodextrin complex solubility. AU - Hirlekar,Rajashree S, AU - Sonawane,Suneeta N, AU - Kadam,Vilasrao J, Y1 - 2009/06/27/ PY - 2008/08/25/received PY - 2009/06/10/accepted PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2010/2/4/medline SP - 858 EP - 63 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 10 IS - 3 N2 - The effect of complexation of irbesartan (IRB), a practically water-insoluble drug, with cyclodextrins in presence of different concentrations of water-soluble polymers (PEG 4000 and PVP K-90) on the dissolution rate of the drug has been investigated. Phase solubility studies were carried out to evaluate the solubilizing power of betaCD in association with water-soluble polymers towards IRB and to determine the apparent stability constant (K (S)) of the complexes. Improvement in K(S) value for ternary complexes (IRB-betaCD-polymers) clearly proved the benefit on the addition of water-soluble polymer to increase complexation efficiency. The dissolution rate of the drug from ternary systems containing PEG 4000 and PVP K-90 was higher as compared to the binary system. An optimum increase in the dissolution rate of the drug was observed at a polymer concentration of 5% w/w for PVP K-90 and 10% w/w for PEG 4000. DSC, FTIR, SEM, and XRD studies were carried out to characterize the complexes. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/19562489/Studies_on_the_effect_of_water_soluble_polymers_on_drug_cyclodextrin_complex_solubility_ L2 - https://dx.doi.org/10.1208/s12249-009-9274-6 DB - PRIME DP - Unbound Medicine ER -