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Studies on the effect of water-soluble polymers on drug-cyclodextrin complex solubility.
AAPS PharmSciTech. 2009; 10(3):858-63.AP

Abstract

The effect of complexation of irbesartan (IRB), a practically water-insoluble drug, with cyclodextrins in presence of different concentrations of water-soluble polymers (PEG 4000 and PVP K-90) on the dissolution rate of the drug has been investigated. Phase solubility studies were carried out to evaluate the solubilizing power of betaCD in association with water-soluble polymers towards IRB and to determine the apparent stability constant (K (S)) of the complexes. Improvement in K(S) value for ternary complexes (IRB-betaCD-polymers) clearly proved the benefit on the addition of water-soluble polymer to increase complexation efficiency. The dissolution rate of the drug from ternary systems containing PEG 4000 and PVP K-90 was higher as compared to the binary system. An optimum increase in the dissolution rate of the drug was observed at a polymer concentration of 5% w/w for PVP K-90 and 10% w/w for PEG 4000. DSC, FTIR, SEM, and XRD studies were carried out to characterize the complexes.

Authors+Show Affiliations

Department of Pharmaceutics, Bharati Vidyapeeth's College of Pharmacy, Sec-8, CBD Belapur, Navi Mumbai 400 614, Maharashtra, India. rshirlekar@rediffmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19562489

Citation

Hirlekar, Rajashree S., et al. "Studies On the Effect of Water-soluble Polymers On Drug-cyclodextrin Complex Solubility." AAPS PharmSciTech, vol. 10, no. 3, 2009, pp. 858-63.
Hirlekar RS, Sonawane SN, Kadam VJ. Studies on the effect of water-soluble polymers on drug-cyclodextrin complex solubility. AAPS PharmSciTech. 2009;10(3):858-63.
Hirlekar, R. S., Sonawane, S. N., & Kadam, V. J. (2009). Studies on the effect of water-soluble polymers on drug-cyclodextrin complex solubility. AAPS PharmSciTech, 10(3), 858-63. https://doi.org/10.1208/s12249-009-9274-6
Hirlekar RS, Sonawane SN, Kadam VJ. Studies On the Effect of Water-soluble Polymers On Drug-cyclodextrin Complex Solubility. AAPS PharmSciTech. 2009;10(3):858-63. PubMed PMID: 19562489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies on the effect of water-soluble polymers on drug-cyclodextrin complex solubility. AU - Hirlekar,Rajashree S, AU - Sonawane,Suneeta N, AU - Kadam,Vilasrao J, Y1 - 2009/06/27/ PY - 2008/08/25/received PY - 2009/06/10/accepted PY - 2009/6/30/entrez PY - 2009/6/30/pubmed PY - 2010/2/4/medline SP - 858 EP - 63 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 10 IS - 3 N2 - The effect of complexation of irbesartan (IRB), a practically water-insoluble drug, with cyclodextrins in presence of different concentrations of water-soluble polymers (PEG 4000 and PVP K-90) on the dissolution rate of the drug has been investigated. Phase solubility studies were carried out to evaluate the solubilizing power of betaCD in association with water-soluble polymers towards IRB and to determine the apparent stability constant (K (S)) of the complexes. Improvement in K(S) value for ternary complexes (IRB-betaCD-polymers) clearly proved the benefit on the addition of water-soluble polymer to increase complexation efficiency. The dissolution rate of the drug from ternary systems containing PEG 4000 and PVP K-90 was higher as compared to the binary system. An optimum increase in the dissolution rate of the drug was observed at a polymer concentration of 5% w/w for PVP K-90 and 10% w/w for PEG 4000. DSC, FTIR, SEM, and XRD studies were carried out to characterize the complexes. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/19562489/Studies_on_the_effect_of_water_soluble_polymers_on_drug_cyclodextrin_complex_solubility_ L2 - https://dx.doi.org/10.1208/s12249-009-9274-6 DB - PRIME DP - Unbound Medicine ER -