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Prevalence, number and morphological types of multinucleated histiocytic giant cells in equine inflammatory dermatoses: a retrospective light microscopic study of skin-biopsy specimens from 362 horses.
Equine Vet J. 2009 Apr; 41(4):406-9.EV

Abstract

REASONS FOR PERFORMING STUDY

Multinucleated histiocytic giant cells (MHGC) are seen frequently in skin-biopsy specimens from horses with inflammatory dermatoses. However, the prevalence, number and morphological types of these cells have not been reported.

OBJECTIVE

To determine the prevalence, number and morphological types of MHGC in equine inflammatory dermatoses, and the association of these cells with specific conditions.

METHODS

Skin-biopsy specimens from 335 horses with inflammatory dermatoses and from 27 horses with normal skin were evaluated for the prevalence, number and morphological types of MHGC.

RESULTS

The prevalence and number of MHGC were greater in granulomatous dermatoses than in nongranulomatous dermatoses. Infectious and noninfectious dermatoses were not different in terms of prevalence or morphological types of MHGC. Foreign-body MHGC were the predominant type in almost all cases. MHGC were not seen in normal skin.

CONCLUSIONS

MHGC are seen in a wide variety of equine inflammatory dermatoses, especially those that are granulomatous. Number and morphological types of MHGC are of no apparent diagnostic significance.

POTENTIAL RELEVANCE

MHGC are frequently present in a wide variety of inflammatory dermatoses in the horse. Because the prevalence, number and morphological types of MHGC are of minimal diagnostic significance, special stains and tissue cultures are necessary to confirm specific diagnoses.

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Authors+Show Affiliations

Cohen RD
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Scott DW
No affiliation info available
Erb HN
No affiliation info available

MeSH

AnimalsBiopsyGiant CellsHorse DiseasesHorsesInflammationMicroscopyRetrospective StudiesSkinSkin Diseases

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19562905

Citation

Cohen, R D., et al. "Prevalence, Number and Morphological Types of Multinucleated Histiocytic Giant Cells in Equine Inflammatory Dermatoses: a Retrospective Light Microscopic Study of Skin-biopsy Specimens From 362 Horses." Equine Veterinary Journal, vol. 41, no. 4, 2009, pp. 406-9.
Cohen RD, Scott DW, Erb HN. Prevalence, number and morphological types of multinucleated histiocytic giant cells in equine inflammatory dermatoses: a retrospective light microscopic study of skin-biopsy specimens from 362 horses. Equine Vet J. 2009;41(4):406-9.
Cohen, R. D., Scott, D. W., & Erb, H. N. (2009). Prevalence, number and morphological types of multinucleated histiocytic giant cells in equine inflammatory dermatoses: a retrospective light microscopic study of skin-biopsy specimens from 362 horses. Equine Veterinary Journal, 41(4), 406-9.
Cohen RD, Scott DW, Erb HN. Prevalence, Number and Morphological Types of Multinucleated Histiocytic Giant Cells in Equine Inflammatory Dermatoses: a Retrospective Light Microscopic Study of Skin-biopsy Specimens From 362 Horses. Equine Vet J. 2009;41(4):406-9. PubMed PMID: 19562905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence, number and morphological types of multinucleated histiocytic giant cells in equine inflammatory dermatoses: a retrospective light microscopic study of skin-biopsy specimens from 362 horses. AU - Cohen,R D, AU - Scott,D W, AU - Erb,H N, PY - 2009/7/1/entrez PY - 2009/7/1/pubmed PY - 2009/7/29/medline SP - 406 EP - 9 JF - Equine veterinary journal JO - Equine Vet J VL - 41 IS - 4 N2 - REASONS FOR PERFORMING STUDY: Multinucleated histiocytic giant cells (MHGC) are seen frequently in skin-biopsy specimens from horses with inflammatory dermatoses. However, the prevalence, number and morphological types of these cells have not been reported. OBJECTIVE: To determine the prevalence, number and morphological types of MHGC in equine inflammatory dermatoses, and the association of these cells with specific conditions. METHODS: Skin-biopsy specimens from 335 horses with inflammatory dermatoses and from 27 horses with normal skin were evaluated for the prevalence, number and morphological types of MHGC. RESULTS: The prevalence and number of MHGC were greater in granulomatous dermatoses than in nongranulomatous dermatoses. Infectious and noninfectious dermatoses were not different in terms of prevalence or morphological types of MHGC. Foreign-body MHGC were the predominant type in almost all cases. MHGC were not seen in normal skin. CONCLUSIONS: MHGC are seen in a wide variety of equine inflammatory dermatoses, especially those that are granulomatous. Number and morphological types of MHGC are of no apparent diagnostic significance. POTENTIAL RELEVANCE: MHGC are frequently present in a wide variety of inflammatory dermatoses in the horse. Because the prevalence, number and morphological types of MHGC are of minimal diagnostic significance, special stains and tissue cultures are necessary to confirm specific diagnoses. SN - 0425-1644 UR - https://www.unboundmedicine.com/medline/citation/19562905/Prevalence_number_and_morphological_types_of_multinucleated_histiocytic_giant_cells_in_equine_inflammatory_dermatoses:_a_retrospective_light_microscopic_study_of_skin_biopsy_specimens_from_362_horses_ L2 - https://doi.org/10.2746/042516409x374212 DB - PRIME DP - Unbound Medicine ER -