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Association of plasma homocysteine and methylenetetrahydrofolate reductase C677T gene variant with schizophrenia: A Chinese Han population-based case-control study.
Psychiatry Res 2009; 168(3):205-8PR

Abstract

This study examined the association of plasma homocysteine levels and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with schizophrenia in the Han population residing in northern China. We detected the MTHFR C677T genotype in 123 schizophrenia patients and compared it with the genotype of 123 controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In addition, by using the cyclophorase method, the plasma homocysteine concentration in 62 schizophrenia patients was determined and then compared with that in 62 controls; these 62 patients and 62 controls were a subset of the 123 patients and 123 controls. We found that the homocysteine levels in the patients were significantly higher than those in the controls. The frequency of homozygosity for the 677T allele of the MTHFR gene was higher in the patient group than in the control group, and the difference between the two groups was statistically significant for both the MTHFR genotype and the frequency of allele homozygosity. A significant difference was observed in the plasma homocysteine levels among the different genotypes in the patient and control groups. In conclusion, both elevated plasma homocysteine levels and variation in the MTHFR 677C-->T gene are related to increased rates of schizophrenia and are risk factors for schizophrenia.

Authors+Show Affiliations

Harbin Medical University, No.23 Youzheng Street, Nangang Block, Harbin, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19564051

Citation

Feng, Lei-Guang, et al. "Association of Plasma Homocysteine and Methylenetetrahydrofolate Reductase C677T Gene Variant With Schizophrenia: a Chinese Han Population-based Case-control Study." Psychiatry Research, vol. 168, no. 3, 2009, pp. 205-8.
Feng LG, Song ZW, Xin F, et al. Association of plasma homocysteine and methylenetetrahydrofolate reductase C677T gene variant with schizophrenia: A Chinese Han population-based case-control study. Psychiatry Res. 2009;168(3):205-8.
Feng, L. G., Song, Z. W., Xin, F., & Hu, J. (2009). Association of plasma homocysteine and methylenetetrahydrofolate reductase C677T gene variant with schizophrenia: A Chinese Han population-based case-control study. Psychiatry Research, 168(3), pp. 205-8. doi:10.1016/j.psychres.2008.05.009.
Feng LG, et al. Association of Plasma Homocysteine and Methylenetetrahydrofolate Reductase C677T Gene Variant With Schizophrenia: a Chinese Han Population-based Case-control Study. Psychiatry Res. 2009 Aug 15;168(3):205-8. PubMed PMID: 19564051.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of plasma homocysteine and methylenetetrahydrofolate reductase C677T gene variant with schizophrenia: A Chinese Han population-based case-control study. AU - Feng,Lei-Guang, AU - Song,Zhi-Wei, AU - Xin,Feng, AU - Hu,Jian, Y1 - 2009/06/28/ PY - 2007/09/05/received PY - 2008/02/26/revised PY - 2008/05/21/accepted PY - 2009/7/1/entrez PY - 2009/7/1/pubmed PY - 2009/9/18/medline SP - 205 EP - 8 JF - Psychiatry research JO - Psychiatry Res VL - 168 IS - 3 N2 - This study examined the association of plasma homocysteine levels and the methylenetetrahydrofolate reductase (MTHFR) gene polymorphism with schizophrenia in the Han population residing in northern China. We detected the MTHFR C677T genotype in 123 schizophrenia patients and compared it with the genotype of 123 controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In addition, by using the cyclophorase method, the plasma homocysteine concentration in 62 schizophrenia patients was determined and then compared with that in 62 controls; these 62 patients and 62 controls were a subset of the 123 patients and 123 controls. We found that the homocysteine levels in the patients were significantly higher than those in the controls. The frequency of homozygosity for the 677T allele of the MTHFR gene was higher in the patient group than in the control group, and the difference between the two groups was statistically significant for both the MTHFR genotype and the frequency of allele homozygosity. A significant difference was observed in the plasma homocysteine levels among the different genotypes in the patient and control groups. In conclusion, both elevated plasma homocysteine levels and variation in the MTHFR 677C-->T gene are related to increased rates of schizophrenia and are risk factors for schizophrenia. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/19564051/Association_of_plasma_homocysteine_and_methylenetetrahydrofolate_reductase_C677T_gene_variant_with_schizophrenia:_A_Chinese_Han_population_based_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(08)00160-1 DB - PRIME DP - Unbound Medicine ER -