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Sudomotor, skin vasomotor, and cardiovascular reflexes in 3 clinical forms of Lewy body disease.
Neurology. 2009 Jul 07; 73(1):59-65.Neur

Abstract

OBJECTIVE

To elucidate the differences among dementia with Lewy bodies (DLB), Parkinson disease with dementia (PDD), and Parkinson disease without dementia (PD), with respect to the involvement of the autonomic nervous system, we clinically investigated the cutaneous and cardiovascular autonomic functions in patients with Lewy body disease.

METHODS

We studied 36 patients with Lewy body disorders, including 12 patients with DLB (age, 75.4 +/- 5.9 years), 12 patients with PDD (71.0 +/- 6.8 years), and 12 patients with PD (70.9 +/- 4.2 years), and 12 healthy control subjects (69.9 +/- 5.3 years). Sympathetic sweat response (SSwR) and skin vasomotor reflex (SkVR) on the palm were recorded to estimate the cutaneous sympathetic function, and the head-up tilt test was performed and coefficient of variation of R-R intervals (CV(R-R)) was studied to estimate the cardiovascular function.

RESULTS

The patients with DLB, patients with PDD, and patients with PD showed severely reduced SSwR amplitudes, significantly lower than that in the controls. The mean SkVR amplitudes in the patients with DLB and patients with PDD were significantly lower than that in the controls, but not in the patients with PD. The mean decreases in the systolic blood pressure during the head-up tilt test in the patients with DLB and patients with PDD were less than that in the controls. The mean CV(R-R) value was significantly lower in the patients with DLB.

CONCLUSION

Sudomotor function on the palm may be severely affected in Lewy body disorders, while skin vasomotor function and the cardiovascular system may be more severely affected in dementia with Lewy bodies and Parkinson disease with dementia than in Parkinson disease.

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Authors+Show Affiliations

Akaogi Y
Department of Neurology, Chiba University School of Medicine, Chiba, Japan.
Asahina M
No affiliation info available
Yamanaka Y
No affiliation info available
Koyama Y
No affiliation info available
Hattori T
No affiliation info available

MeSH

AgedAged, 80 and overAutonomic Nervous System DiseasesBlood PressureCardiovascular DiseasesCardiovascular SystemFemaleGalvanic Skin ResponseHumansLewy Body DiseaseMaleMicrocirculationNeurologic ExaminationParkinson DiseaseReflex, AbnormalRegional Blood FlowSkinSweat Gland DiseasesSweat GlandsSympathetic Fibers, PostganglionicTilt-Table TestVasomotor System

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19564585

Citation

Akaogi, Y, et al. "Sudomotor, Skin Vasomotor, and Cardiovascular Reflexes in 3 Clinical Forms of Lewy Body Disease." Neurology, vol. 73, no. 1, 2009, pp. 59-65.
Akaogi Y, Asahina M, Yamanaka Y, et al. Sudomotor, skin vasomotor, and cardiovascular reflexes in 3 clinical forms of Lewy body disease. Neurology. 2009;73(1):59-65.
Akaogi, Y., Asahina, M., Yamanaka, Y., Koyama, Y., & Hattori, T. (2009). Sudomotor, skin vasomotor, and cardiovascular reflexes in 3 clinical forms of Lewy body disease. Neurology, 73(1), 59-65. https://doi.org/10.1212/WNL.0b013e3181aae83c
Akaogi Y, et al. Sudomotor, Skin Vasomotor, and Cardiovascular Reflexes in 3 Clinical Forms of Lewy Body Disease. Neurology. 2009 Jul 7;73(1):59-65. PubMed PMID: 19564585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sudomotor, skin vasomotor, and cardiovascular reflexes in 3 clinical forms of Lewy body disease. AU - Akaogi,Y, AU - Asahina,M, AU - Yamanaka,Y, AU - Koyama,Y, AU - Hattori,T, PY - 2009/7/1/entrez PY - 2009/7/1/pubmed PY - 2009/8/18/medline SP - 59 EP - 65 JF - Neurology JO - Neurology VL - 73 IS - 1 N2 - OBJECTIVE: To elucidate the differences among dementia with Lewy bodies (DLB), Parkinson disease with dementia (PDD), and Parkinson disease without dementia (PD), with respect to the involvement of the autonomic nervous system, we clinically investigated the cutaneous and cardiovascular autonomic functions in patients with Lewy body disease. METHODS: We studied 36 patients with Lewy body disorders, including 12 patients with DLB (age, 75.4 +/- 5.9 years), 12 patients with PDD (71.0 +/- 6.8 years), and 12 patients with PD (70.9 +/- 4.2 years), and 12 healthy control subjects (69.9 +/- 5.3 years). Sympathetic sweat response (SSwR) and skin vasomotor reflex (SkVR) on the palm were recorded to estimate the cutaneous sympathetic function, and the head-up tilt test was performed and coefficient of variation of R-R intervals (CV(R-R)) was studied to estimate the cardiovascular function. RESULTS: The patients with DLB, patients with PDD, and patients with PD showed severely reduced SSwR amplitudes, significantly lower than that in the controls. The mean SkVR amplitudes in the patients with DLB and patients with PDD were significantly lower than that in the controls, but not in the patients with PD. The mean decreases in the systolic blood pressure during the head-up tilt test in the patients with DLB and patients with PDD were less than that in the controls. The mean CV(R-R) value was significantly lower in the patients with DLB. CONCLUSION: Sudomotor function on the palm may be severely affected in Lewy body disorders, while skin vasomotor function and the cardiovascular system may be more severely affected in dementia with Lewy bodies and Parkinson disease with dementia than in Parkinson disease. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/19564585/Sudomotor_skin_vasomotor_and_cardiovascular_reflexes_in_3_clinical_forms_of_Lewy_body_disease_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=19564585 DB - PRIME DP - Unbound Medicine ER -