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Dietary beta-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Abstract

So far, studies on dietary antioxidant intake, including beta-carotene, vitamin C and vitamin E, and breast cancer risk are inconclusive. Thus, we addressed this question in the European Prospective Investigation into Cancer and Nutrition. During a median follow-up time of 8.8 years, 7,502 primary invasive breast cancer cases were identified. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). All analyses were run stratified by menopausal status at recruitment and, additionally, by smoking status, alcohol intake, use of exogenous hormones and use of dietary supplements. In the multivariate analyses, dietary intake of beta-carotene, vitamin C and E was not associated with breast cancer risk in premenopausal [highest vs. lowest quintile: HR, 1.04 (95% CI, 0.85-1.27), 1.12 (0.92-1.36) and 1.11 (0.84-1.46), respectively] and postmenopausal women [0.93 (0.82-1.04), 0.98 (0.87-1.11) and 0.92 (0.77-1.11), respectively]. However, in postmenopausal women using exogenous hormones, high intake of beta-carotene [highest vs. lowest quintile; HR 0.79 (95% CI, 0.66-0.96), P (trend) 0.06] and vitamin C [0.88 (0.72-1.07), P (trend) 0.05] was associated with reduced breast cancer risk. In addition, dietary beta-carotene was associated with a decreased risk in postmenopausal women with high alcohol intake. Overall, dietary intake of beta-carotene, vitamin C and E was not related to breast cancer risk in neither pre- nor postmenopausal women. However, in subgroups of postmenopausal women, a weak protective effect between beta-carotene and vitamin E from food and breast cancer risk cannot be excluded.

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  • Authors+Show Affiliations

    ,

    Institute of Epidemiology, Ulm University, Helmholtzstr.22, 89081 Ulm, Germany. gabriele.nagel@uni-ulm.de

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    Breast cancer research and treatment 119:3 2010 Feb pg 753-65

    MeSH

    Adult
    Aged
    Antioxidants
    Ascorbic Acid
    Breast Neoplasms
    Diet
    Europe
    Female
    Humans
    Middle Aged
    Postmenopause
    Premenopause
    Proportional Hazards Models
    Risk
    Surveys and Questionnaires
    Vitamin E
    beta Carotene

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19565333

    Citation

    Nagel, G, et al. "Dietary Beta-carotene, Vitamin C and E Intake and Breast Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC)." Breast Cancer Research and Treatment, vol. 119, no. 3, 2010, pp. 753-65.
    Nagel G, Linseisen J, van Gils CH, et al. Dietary beta-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Breast Cancer Res Treat. 2010;119(3):753-65.
    Nagel, G., Linseisen, J., van Gils, C. H., Peeters, P. H., Boutron-Ruault, M. C., Clavel-Chapelon, F., ... Riboli, E. (2010). Dietary beta-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Breast Cancer Research and Treatment, 119(3), pp. 753-65. doi:10.1007/s10549-009-0444-8.
    Nagel G, et al. Dietary Beta-carotene, Vitamin C and E Intake and Breast Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC). Breast Cancer Res Treat. 2010;119(3):753-65. PubMed PMID: 19565333.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary beta-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). AU - Nagel,G, AU - Linseisen,J, AU - van Gils,C H, AU - Peeters,P H, AU - Boutron-Ruault,M C, AU - Clavel-Chapelon,F, AU - Romieu,I, AU - Tjønneland,A, AU - Olsen,A, AU - Roswall,N, AU - Witt,P M, AU - Overvad,K, AU - Rohrmann,S, AU - Kaaks,R, AU - Drogan,D, AU - Boeing,H, AU - Trichopoulou,A, AU - Stratigakou,V, AU - Zylis,D, AU - Engeset,D, AU - Lund,E, AU - Skeie,G, AU - Berrino,F, AU - Grioni,S, AU - Mattiello,A, AU - Masala,G, AU - Tumino,R, AU - Zanetti,R, AU - Ros,M M, AU - Bueno-de-Mesquita,H B, AU - Ardanaz,E, AU - Sánchez,M J, AU - Huerta,J M, AU - Amiano,P, AU - Rodríguez,L, AU - Manjer,J, AU - Wirfält,E, AU - Lenner,P, AU - Hallmans,G, AU - Spencer,E A, AU - Key,T J, AU - Bingham,S, AU - Khaw,K T, AU - Rinaldi,S, AU - Slimani,N, AU - Boffetta,P, AU - Gallo,V, AU - Norat,T, AU - Riboli,E, Y1 - 2009/06/30/ PY - 2009/03/05/received PY - 2009/06/10/accepted PY - 2009/7/1/entrez PY - 2009/7/1/pubmed PY - 2010/3/24/medline SP - 753 EP - 65 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 119 IS - 3 N2 - So far, studies on dietary antioxidant intake, including beta-carotene, vitamin C and vitamin E, and breast cancer risk are inconclusive. Thus, we addressed this question in the European Prospective Investigation into Cancer and Nutrition. During a median follow-up time of 8.8 years, 7,502 primary invasive breast cancer cases were identified. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). All analyses were run stratified by menopausal status at recruitment and, additionally, by smoking status, alcohol intake, use of exogenous hormones and use of dietary supplements. In the multivariate analyses, dietary intake of beta-carotene, vitamin C and E was not associated with breast cancer risk in premenopausal [highest vs. lowest quintile: HR, 1.04 (95% CI, 0.85-1.27), 1.12 (0.92-1.36) and 1.11 (0.84-1.46), respectively] and postmenopausal women [0.93 (0.82-1.04), 0.98 (0.87-1.11) and 0.92 (0.77-1.11), respectively]. However, in postmenopausal women using exogenous hormones, high intake of beta-carotene [highest vs. lowest quintile; HR 0.79 (95% CI, 0.66-0.96), P (trend) 0.06] and vitamin C [0.88 (0.72-1.07), P (trend) 0.05] was associated with reduced breast cancer risk. In addition, dietary beta-carotene was associated with a decreased risk in postmenopausal women with high alcohol intake. Overall, dietary intake of beta-carotene, vitamin C and E was not related to breast cancer risk in neither pre- nor postmenopausal women. However, in subgroups of postmenopausal women, a weak protective effect between beta-carotene and vitamin E from food and breast cancer risk cannot be excluded. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/19565333/Dietary_beta_carotene_vitamin_C_and_E_intake_and_breast_cancer_risk_in_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC__ L2 - https://doi.org/10.1007/s10549-009-0444-8 DB - PRIME DP - Unbound Medicine ER -