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SERS microscopy: nanoparticle probes and biomedical applications.
Chemphyschem. 2009 Jul 13; 10(9-10):1344-54.C

Abstract

Surface-enhanced Raman scattering (SERS) microscopy is a novel method of vibrational microspectroscopic imaging for the selective detection of biomolecules in targeted research. This technique combines the advantages of biofunctionalized metal nanoparticles and Raman microspectroscopy for visualizing and quantifying the distribution of target molecules such as proteins in cells and tissues. Advantages of SERS over existing labeling approaches include the tremendous multiplexing capacity, quantification using the characteristic SERS signatures and high photostability. This review summarizes current designs of nanoparticle-based SERS probes and highlights first biomedical applications of SERS microscopy for protein localization ex and in vivo.

Authors+Show Affiliations

Department of Physics, University of Osnabrück, D-49069 Osnabrück, Germany. sebastian.schluecker@uos.de

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19565576

Citation

Schlücker, Sebastian. "SERS Microscopy: Nanoparticle Probes and Biomedical Applications." Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry, vol. 10, no. 9-10, 2009, pp. 1344-54.
Schlücker S. SERS microscopy: nanoparticle probes and biomedical applications. Chemphyschem. 2009;10(9-10):1344-54.
Schlücker, S. (2009). SERS microscopy: nanoparticle probes and biomedical applications. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry, 10(9-10), 1344-54. https://doi.org/10.1002/cphc.200900119
Schlücker S. SERS Microscopy: Nanoparticle Probes and Biomedical Applications. Chemphyschem. 2009 Jul 13;10(9-10):1344-54. PubMed PMID: 19565576.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SERS microscopy: nanoparticle probes and biomedical applications. A1 - Schlücker,Sebastian, PY - 2009/7/1/entrez PY - 2009/7/1/pubmed PY - 2009/10/14/medline SP - 1344 EP - 54 JF - Chemphyschem : a European journal of chemical physics and physical chemistry JO - Chemphyschem VL - 10 IS - 9-10 N2 - Surface-enhanced Raman scattering (SERS) microscopy is a novel method of vibrational microspectroscopic imaging for the selective detection of biomolecules in targeted research. This technique combines the advantages of biofunctionalized metal nanoparticles and Raman microspectroscopy for visualizing and quantifying the distribution of target molecules such as proteins in cells and tissues. Advantages of SERS over existing labeling approaches include the tremendous multiplexing capacity, quantification using the characteristic SERS signatures and high photostability. This review summarizes current designs of nanoparticle-based SERS probes and highlights first biomedical applications of SERS microscopy for protein localization ex and in vivo. SN - 1439-7641 UR - https://www.unboundmedicine.com/medline/citation/19565576/SERS_microscopy:_nanoparticle_probes_and_biomedical_applications_ L2 - https://doi.org/10.1002/cphc.200900119 DB - PRIME DP - Unbound Medicine ER -