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[Therapeutic effects of traditional Chinese herbal formula with Smilax glabra on mice's lead poisoning].
Zhong Yao Cai 2009; 32(3):404-6ZY

Abstract

OBJECTIVE

To investigate the influence of traditional Chinese herbal formula with Smilax glabra on lead expelling and oxidative damage in lead-poisoned mice.

METHODS

Mice were received intraperitoneal injections of lead acetate to establish lead-poisoned models. The concentration of lead, zinc and copper in blood, brain, liver, kidney and bone were determined. The lipid peroxidation of liver was systematically evaluated.

RESULTS

The traditional Chinese herbal formula had no influence on body weight and organ weight/body weight ratio of lead-poisoned mice. The traditional Chinese herbal formula might significantly reduce the concentration of lead in blood, rain, liver, kidney and bone, and the rate were 74%, 48%, 56%, 51% and 44%, but had no influence on zinc's and copper' s concentration. The decreasing rate of MDA levels in liver by the traditional Chinese herbal formula was 31%. In addition, the increase rate of GSH levels and the activities of GSH-Px and SOD in liver by traditional Chinese herbal formula were 63% ,76% and 66%, respectively.

CONCLUSIONS

The traditional Chinese herbal formula with Smilax glabra can significantly advance the excretion of lead and protect liver against oxidative damage induced by lead.

Authors+Show Affiliations

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China. xiadaozong@zjtcm.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

19565723

Citation

Xia, Dao-Zong, et al. "[Therapeutic Effects of Traditional Chinese Herbal Formula With Smilax Glabra On Mice's Lead Poisoning]." Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, vol. 32, no. 3, 2009, pp. 404-6.
Xia DZ, Wang HM, Yang Q, et al. [Therapeutic effects of traditional Chinese herbal formula with Smilax glabra on mice's lead poisoning]. Zhong Yao Cai. 2009;32(3):404-6.
Xia, D. Z., Wang, H. M., Yang, Q., Jiang, L. Q., & Xia, M. (2009). [Therapeutic effects of traditional Chinese herbal formula with Smilax glabra on mice's lead poisoning]. Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials, 32(3), pp. 404-6.
Xia DZ, et al. [Therapeutic Effects of Traditional Chinese Herbal Formula With Smilax Glabra On Mice's Lead Poisoning]. Zhong Yao Cai. 2009;32(3):404-6. PubMed PMID: 19565723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Therapeutic effects of traditional Chinese herbal formula with Smilax glabra on mice's lead poisoning]. AU - Xia,Dao-Zong, AU - Wang,Hui-Ming, AU - Yang,Qing, AU - Jiang,Li-Qin, AU - Xia,Ming, PY - 2009/7/2/entrez PY - 2009/7/2/pubmed PY - 2009/9/9/medline SP - 404 EP - 6 JF - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials JO - Zhong Yao Cai VL - 32 IS - 3 N2 - OBJECTIVE: To investigate the influence of traditional Chinese herbal formula with Smilax glabra on lead expelling and oxidative damage in lead-poisoned mice. METHODS: Mice were received intraperitoneal injections of lead acetate to establish lead-poisoned models. The concentration of lead, zinc and copper in blood, brain, liver, kidney and bone were determined. The lipid peroxidation of liver was systematically evaluated. RESULTS: The traditional Chinese herbal formula had no influence on body weight and organ weight/body weight ratio of lead-poisoned mice. The traditional Chinese herbal formula might significantly reduce the concentration of lead in blood, rain, liver, kidney and bone, and the rate were 74%, 48%, 56%, 51% and 44%, but had no influence on zinc's and copper' s concentration. The decreasing rate of MDA levels in liver by the traditional Chinese herbal formula was 31%. In addition, the increase rate of GSH levels and the activities of GSH-Px and SOD in liver by traditional Chinese herbal formula were 63% ,76% and 66%, respectively. CONCLUSIONS: The traditional Chinese herbal formula with Smilax glabra can significantly advance the excretion of lead and protect liver against oxidative damage induced by lead. SN - 1001-4454 UR - https://www.unboundmedicine.com/medline/citation/19565723/[Therapeutic_effects_of_traditional_Chinese_herbal_formula_with_Smilax_glabra_on_mice's_lead_poisoning]_ L2 - https://medlineplus.gov/leadpoisoning.html DB - PRIME DP - Unbound Medicine ER -