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[Study on the mechanism of electroacupuncture scalp point penetration therapy in action on apoptosis in the Parkinson's disease rat model].

Abstract

OBJECTIVE

To explore the mechanism of electroacupuncture scalp point penetration therapy in treatment of the Parkinson's disease (PD).

METHODS

Forty Wistar rats were randomly divided into a normal group, a sham-operation group, a model group and an electroacupuncture (EA) group. 6-OHDA was injected into the left striatum to make lateralization PD rat model. Acupuncture at "Baihui" (GV 20)-through-"Taiyang" (EX-HN 5), once each day, 6 days constituting one course. Immunohistochemical method was used to observe the facio-density and the integral optical density of brain-derived neurotrophic factor (BDNF) in the left substantia nigra, and TUNEL method was used to observe the apoptotic amount, and high performance liquid chromatography was used to observe DA contents of the left striatum in each group.

RESULTS

As compared with the model group, in the acupuncture group, the facio-density and the integral optical density in the left substantia nigra increased significantly (P < 0.05), the amount of apoptosis decreased significantly (P < 0.05), and the content of striatum DA increased significantly (P < 0.05).

CONCLUSION

EA scalp point-through-point therapy may enhance BDNF protein expression level in the substantia nigra to decrease the amount of apoptosis in the PD model rat.

Authors+Show Affiliations

,

Department of Acup-Moxibustion, Heilongjiang Academy of TCM, Harbin 150036, China. hljwang@yahoo.com.cn

,

Source

MeSH

Acupuncture Points
Animals
Apoptosis
Brain-Derived Neurotrophic Factor
Electroacupuncture
Female
Immunohistochemistry
In Situ Nick-End Labeling
Male
Oxidopamine
Parkinson Disease, Secondary
Random Allocation
Rats
Rats, Wistar
Scalp
Substantia Nigra
Treatment Outcome

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

19565741

Citation

Wang, Shun, et al. "[Study On the Mechanism of Electroacupuncture Scalp Point Penetration Therapy in Action On Apoptosis in the Parkinson's Disease Rat Model]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 29, no. 4, 2009, pp. 309-13.
Wang S, Jiang H, Qu L. [Study on the mechanism of electroacupuncture scalp point penetration therapy in action on apoptosis in the Parkinson's disease rat model]. Zhongguo Zhen Jiu. 2009;29(4):309-13.
Wang, S., Jiang, H., & Qu, L. (2009). [Study on the mechanism of electroacupuncture scalp point penetration therapy in action on apoptosis in the Parkinson's disease rat model]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 29(4), pp. 309-13.
Wang S, Jiang H, Qu L. [Study On the Mechanism of Electroacupuncture Scalp Point Penetration Therapy in Action On Apoptosis in the Parkinson's Disease Rat Model]. Zhongguo Zhen Jiu. 2009;29(4):309-13. PubMed PMID: 19565741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on the mechanism of electroacupuncture scalp point penetration therapy in action on apoptosis in the Parkinson's disease rat model]. AU - Wang,Shun, AU - Jiang,Hua, AU - Qu,Long, PY - 2009/7/2/entrez PY - 2009/7/2/pubmed PY - 2009/7/29/medline SP - 309 EP - 13 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 29 IS - 4 N2 - OBJECTIVE: To explore the mechanism of electroacupuncture scalp point penetration therapy in treatment of the Parkinson's disease (PD). METHODS: Forty Wistar rats were randomly divided into a normal group, a sham-operation group, a model group and an electroacupuncture (EA) group. 6-OHDA was injected into the left striatum to make lateralization PD rat model. Acupuncture at "Baihui" (GV 20)-through-"Taiyang" (EX-HN 5), once each day, 6 days constituting one course. Immunohistochemical method was used to observe the facio-density and the integral optical density of brain-derived neurotrophic factor (BDNF) in the left substantia nigra, and TUNEL method was used to observe the apoptotic amount, and high performance liquid chromatography was used to observe DA contents of the left striatum in each group. RESULTS: As compared with the model group, in the acupuncture group, the facio-density and the integral optical density in the left substantia nigra increased significantly (P < 0.05), the amount of apoptosis decreased significantly (P < 0.05), and the content of striatum DA increased significantly (P < 0.05). CONCLUSION: EA scalp point-through-point therapy may enhance BDNF protein expression level in the substantia nigra to decrease the amount of apoptosis in the PD model rat. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/19565741/[Study_on_the_mechanism_of_electroacupuncture_scalp_point_penetration_therapy_in_action_on_apoptosis_in_the_Parkinson's_disease_rat_model]_ DB - PRIME DP - Unbound Medicine ER -