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Smoking and venous thromboembolism: a Danish follow-up study.

Abstract

BACKGROUND

Large-scale prospective studies are needed to assess whether smoking is associated with venous thromboembolism (VTE) (i.e. deep venous thrombosis and pulmonary embolism) independently of established risk factors.

OBJECTIVE

To investigate the association between smoking and the risk of VTE among middle-aged men and women.

METHODS

From 1993 to 1997, 27,178 men and 29,875 women, aged 50-64 years and born in Denmark, were recruited into the Danish prospective study 'Diet, Cancer and Health'. During follow-up, VTE cases were identified in the Danish National Patient Registry. Medical records were reviewed and only verified VTE cases were included in the study. Baseline data on smoking and potential confounders were included in gender stratified Cox proportional hazard models to asses the association between smoking and the risk of VTE. The analyses were adjusted for alcohol intake, body mass index, physical activity, and in women also for use of hormone replacement therapy.

RESULTS

During follow-up, 641 incident cases of VTE were verified. We found a positive association between current smoking and VTE, with a hazard ratio of 1.52 (95% CI, 1.15-2.00) for smoking women and 1.32 (95% CI, 1.00-1.74) for smoking men, and a positive dose-response relationship. Former smokers had the same hazard as never smokers.

CONCLUSIONS

Smoking was an independent risk factor for VTE among middle-aged men and women. Former smokers have the same risk of VTE as never smokers, indicating acute effects of smoking, and underscoring the potential benefits of smoking cessation.

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  • Authors+Show Affiliations

    ,

    Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark. m.severinsen@rn.dk

    , , , ,

    Source

    MeSH

    Denmark
    Female
    Follow-Up Studies
    Humans
    Male
    Middle Aged
    Proportional Hazards Models
    Risk Factors
    Sex Factors
    Smoking
    Venous Thromboembolism

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19566546

    Citation

    Severinsen, M T., et al. "Smoking and Venous Thromboembolism: a Danish Follow-up Study." Journal of Thrombosis and Haemostasis : JTH, vol. 7, no. 8, 2009, pp. 1297-303.
    Severinsen MT, Kristensen SR, Johnsen SP, et al. Smoking and venous thromboembolism: a Danish follow-up study. J Thromb Haemost. 2009;7(8):1297-303.
    Severinsen, M. T., Kristensen, S. R., Johnsen, S. P., Dethlefsen, C., Tjønneland, A., & Overvad, K. (2009). Smoking and venous thromboembolism: a Danish follow-up study. Journal of Thrombosis and Haemostasis : JTH, 7(8), pp. 1297-303. doi:10.1111/j.1538-7836.2009.03490.x.
    Severinsen MT, et al. Smoking and Venous Thromboembolism: a Danish Follow-up Study. J Thromb Haemost. 2009;7(8):1297-303. PubMed PMID: 19566546.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Smoking and venous thromboembolism: a Danish follow-up study. AU - Severinsen,M T, AU - Kristensen,S R, AU - Johnsen,S P, AU - Dethlefsen,C, AU - Tjønneland,A, AU - Overvad,K, Y1 - 2009/06/30/ PY - 2009/7/2/entrez PY - 2009/7/2/pubmed PY - 2009/12/31/medline SP - 1297 EP - 303 JF - Journal of thrombosis and haemostasis : JTH JO - J. Thromb. Haemost. VL - 7 IS - 8 N2 - BACKGROUND: Large-scale prospective studies are needed to assess whether smoking is associated with venous thromboembolism (VTE) (i.e. deep venous thrombosis and pulmonary embolism) independently of established risk factors. OBJECTIVE: To investigate the association between smoking and the risk of VTE among middle-aged men and women. METHODS: From 1993 to 1997, 27,178 men and 29,875 women, aged 50-64 years and born in Denmark, were recruited into the Danish prospective study 'Diet, Cancer and Health'. During follow-up, VTE cases were identified in the Danish National Patient Registry. Medical records were reviewed and only verified VTE cases were included in the study. Baseline data on smoking and potential confounders were included in gender stratified Cox proportional hazard models to asses the association between smoking and the risk of VTE. The analyses were adjusted for alcohol intake, body mass index, physical activity, and in women also for use of hormone replacement therapy. RESULTS: During follow-up, 641 incident cases of VTE were verified. We found a positive association between current smoking and VTE, with a hazard ratio of 1.52 (95% CI, 1.15-2.00) for smoking women and 1.32 (95% CI, 1.00-1.74) for smoking men, and a positive dose-response relationship. Former smokers had the same hazard as never smokers. CONCLUSIONS: Smoking was an independent risk factor for VTE among middle-aged men and women. Former smokers have the same risk of VTE as never smokers, indicating acute effects of smoking, and underscoring the potential benefits of smoking cessation. SN - 1538-7836 UR - https://www.unboundmedicine.com/medline/citation/19566546/Smoking_and_venous_thromboembolism:_a_Danish_follow_up_study_ L2 - https://doi.org/10.1111/j.1538-7836.2009.03490.x DB - PRIME DP - Unbound Medicine ER -