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Dengue virus antibodies in blood donors from an endemic area.
Transfus Med. 2009 Jun; 19(3):125-31.TM

Abstract

We evaluated the incidence of anti-Dengue virus (DENV) antibodies and dengue viremia in a region of Mexico with a high prevalence of dengue. DENV is the most important arthropod-borne virus in terms of human morbidity and mortality in America We tested 800 blood donors from a tertiary care teaching hospital that provides care in Northeast Mexico, to identify anti-DENV IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA) and DENV genome by reverse transcription polymerase chain reaction (RT-PCR). In addition, routine tests for donors including Brucella, Hepatitis C virus (HCV), Venereal Disease Research Laboratory (VDRL), HIV-1 and HBsAg identification were performed. We found that 59% of donors were reactive for anti-DENV IgG and none of them had reported recent DENV infection; however, 16 (2%) were reactive for anti-DENV IgM antibodies. None of them were viremic at the time of donation. Routine tests showed that the prevalence of anti-Brucella was 0.71%, anti-HCV 0.71%, anti-HIV-1-2 0.14%, HBsAg 0.14% and VDRL test 0.57%. Although DENV transmission by blood transfusion had not been confirmed in Mexico, the finding of a high prevalence of anti-DENV IgM-positive donors with asymptomatic manifestations and the recent viremia reported in blood donors suggests that this route of transmission might be possible.

Authors+Show Affiliations

Laboratory of Molecular Infectology, Department of Biochemistry and Molecular Medicine, School of Medicine and Hospital Universitario Dr. Jose E. Gonzalez, Universidad Autónoma de Nuevo León Monterrey, NL, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19566669

Citation

Rodríguez Rodríguez, D, et al. "Dengue Virus Antibodies in Blood Donors From an Endemic Area." Transfusion Medicine (Oxford, England), vol. 19, no. 3, 2009, pp. 125-31.
Rodríguez Rodríguez D, Garza Rodríguez M, Chavarria AM, et al. Dengue virus antibodies in blood donors from an endemic area. Transfus Med. 2009;19(3):125-31.
Rodríguez Rodríguez, D., Garza Rodríguez, M., Chavarria, A. M., Ramos-Jiménez, J., Rivera, M. A., Taméz, R. C., Farfan-Ale, J., & Rivas-Estilla, A. M. (2009). Dengue virus antibodies in blood donors from an endemic area. Transfusion Medicine (Oxford, England), 19(3), 125-31. https://doi.org/10.1111/j.1365-3148.2009.00922.x
Rodríguez Rodríguez D, et al. Dengue Virus Antibodies in Blood Donors From an Endemic Area. Transfus Med. 2009;19(3):125-31. PubMed PMID: 19566669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dengue virus antibodies in blood donors from an endemic area. AU - Rodríguez Rodríguez,D, AU - Garza Rodríguez,M, AU - Chavarria,A M, AU - Ramos-Jiménez,J, AU - Rivera,M A, AU - Taméz,R C, AU - Farfan-Ale,J, AU - Rivas-Estilla,A M, PY - 2009/7/2/entrez PY - 2009/7/2/pubmed PY - 2009/9/30/medline SP - 125 EP - 31 JF - Transfusion medicine (Oxford, England) JO - Transfus Med VL - 19 IS - 3 N2 - We evaluated the incidence of anti-Dengue virus (DENV) antibodies and dengue viremia in a region of Mexico with a high prevalence of dengue. DENV is the most important arthropod-borne virus in terms of human morbidity and mortality in America We tested 800 blood donors from a tertiary care teaching hospital that provides care in Northeast Mexico, to identify anti-DENV IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA) and DENV genome by reverse transcription polymerase chain reaction (RT-PCR). In addition, routine tests for donors including Brucella, Hepatitis C virus (HCV), Venereal Disease Research Laboratory (VDRL), HIV-1 and HBsAg identification were performed. We found that 59% of donors were reactive for anti-DENV IgG and none of them had reported recent DENV infection; however, 16 (2%) were reactive for anti-DENV IgM antibodies. None of them were viremic at the time of donation. Routine tests showed that the prevalence of anti-Brucella was 0.71%, anti-HCV 0.71%, anti-HIV-1-2 0.14%, HBsAg 0.14% and VDRL test 0.57%. Although DENV transmission by blood transfusion had not been confirmed in Mexico, the finding of a high prevalence of anti-DENV IgM-positive donors with asymptomatic manifestations and the recent viremia reported in blood donors suggests that this route of transmission might be possible. SN - 1365-3148 UR - https://www.unboundmedicine.com/medline/citation/19566669/Dengue_virus_antibodies_in_blood_donors_from_an_endemic_area_ L2 - https://doi.org/10.1111/j.1365-3148.2009.00922.x DB - PRIME DP - Unbound Medicine ER -