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Comorbidity of cardiovascular diseases with mood and anxiety disorder: a population based 4-year study.
Psychiatry Clin Neurosci 2009; 63(3):401-9PC

Abstract

AIMS

Accumulating evidence from Caucasian patients has shown that depression, bipolar and anxiety disorders are associated with an increased risk of cardiovascular diseases (CVD), but reports in the Asian population are limited, and age effect is rarely investigated. This population-based study was carried out to examine and compare the CVD comorbidities among patients with mood and anxiety disorders in different age groups.

METHOD

A 4-year cross-sectional survey was carried out using the Taiwan National Health Insurance Research Database from 2000 to 2003.

RESULTS

An average total of 1,031,557 patients with mood and anxiety disorders were enrolled as study participants, including 76,430 cases of major depressive disorder, 41,557 cases of bipolar disorder, and 913,570 cases of anxiety disorder. When compared with the insured population without mood or anxiety disorders (average 21,356,304 people), the average relative risk (RR) of developing ischemic heart disease and hypertensive disorders in 1,031,557 study participants was 2.0 and 2.05, respectively. The highest RR was found in the age group under 20 years (RR = 4.74 and 4.08, respectively), and the lowest RR in the age group equal to or older than 65 years (RR = 0.47 and 0.58, respectively).

CONCLUSIONS

Taiwanese patients with mood and anxiety disorders experience high cardiovascular morbidity, especially patients with anxiety disorders. Age acted as an important modifier variable that influenced the relationship between mood, anxiety disorder and CVD. This study highlights the need for future research in different age groups, in order to elucidate the causality and the trajectory of developing CVD among patients with mental disorders.

Authors+Show Affiliations

Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19566773

Citation

Huang, Kai-Lin, et al. "Comorbidity of Cardiovascular Diseases With Mood and Anxiety Disorder: a Population Based 4-year Study." Psychiatry and Clinical Neurosciences, vol. 63, no. 3, 2009, pp. 401-9.
Huang KL, Su TP, Chen TJ, et al. Comorbidity of cardiovascular diseases with mood and anxiety disorder: a population based 4-year study. Psychiatry Clin Neurosci. 2009;63(3):401-9.
Huang, K. L., Su, T. P., Chen, T. J., Chou, Y. H., & Bai, Y. M. (2009). Comorbidity of cardiovascular diseases with mood and anxiety disorder: a population based 4-year study. Psychiatry and Clinical Neurosciences, 63(3), pp. 401-9. doi:10.1111/j.1440-1819.2009.01974.x.
Huang KL, et al. Comorbidity of Cardiovascular Diseases With Mood and Anxiety Disorder: a Population Based 4-year Study. Psychiatry Clin Neurosci. 2009;63(3):401-9. PubMed PMID: 19566773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comorbidity of cardiovascular diseases with mood and anxiety disorder: a population based 4-year study. AU - Huang,Kai-Lin, AU - Su,Tung-Ping, AU - Chen,Tzeng-Ji, AU - Chou,Yuan-Hwa, AU - Bai,Ya-Mei, PY - 2009/7/2/entrez PY - 2009/7/2/pubmed PY - 2009/9/17/medline SP - 401 EP - 9 JF - Psychiatry and clinical neurosciences JO - Psychiatry Clin. Neurosci. VL - 63 IS - 3 N2 - AIMS: Accumulating evidence from Caucasian patients has shown that depression, bipolar and anxiety disorders are associated with an increased risk of cardiovascular diseases (CVD), but reports in the Asian population are limited, and age effect is rarely investigated. This population-based study was carried out to examine and compare the CVD comorbidities among patients with mood and anxiety disorders in different age groups. METHOD: A 4-year cross-sectional survey was carried out using the Taiwan National Health Insurance Research Database from 2000 to 2003. RESULTS: An average total of 1,031,557 patients with mood and anxiety disorders were enrolled as study participants, including 76,430 cases of major depressive disorder, 41,557 cases of bipolar disorder, and 913,570 cases of anxiety disorder. When compared with the insured population without mood or anxiety disorders (average 21,356,304 people), the average relative risk (RR) of developing ischemic heart disease and hypertensive disorders in 1,031,557 study participants was 2.0 and 2.05, respectively. The highest RR was found in the age group under 20 years (RR = 4.74 and 4.08, respectively), and the lowest RR in the age group equal to or older than 65 years (RR = 0.47 and 0.58, respectively). CONCLUSIONS: Taiwanese patients with mood and anxiety disorders experience high cardiovascular morbidity, especially patients with anxiety disorders. Age acted as an important modifier variable that influenced the relationship between mood, anxiety disorder and CVD. This study highlights the need for future research in different age groups, in order to elucidate the causality and the trajectory of developing CVD among patients with mental disorders. SN - 1440-1819 UR - https://www.unboundmedicine.com/medline/citation/19566773/Comorbidity_of_cardiovascular_diseases_with_mood_and_anxiety_disorder:_a_population_based_4_year_study_ L2 - https://doi.org/10.1111/j.1440-1819.2009.01974.x DB - PRIME DP - Unbound Medicine ER -