Tags

Type your tag names separated by a space and hit enter

Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study.

Abstract

BACKGROUND

Although it is believed that fish omega-3 fatty acids may decrease breast cancer risk, epidemiological evidence has been inconclusive. This study examined the association between fish and fish omega-3 fatty acids intake with the risk of breast cancer in a case-control study of Korean women.

METHODS

We recruited 358 incident breast cancer patients and 360 controls with no history of malignant neoplasm from the National Cancer Center Hospital between July 2007 and April 2008. The study participants were given a 103-item food intake frequency questionnaire to determine their dietary consumption of fish (fatty and lean fish) and omega-3 fatty acids derived from fish (eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)).

RESULTS

Using a multivariate logistic regression model, high intake of fatty fish was associated with a reduced risk for breast cancer in both pre- and postmenopausal women (OR [95% CI] for highest vs. lowest intake quartiles, p for trend: 0.19 [0.08 to 0.45], p < 0.001 for premenopausal women, 0.27 [0.11 to 0.66], p = 0.005 for postmenopausal women). Similarly, reductions in breast cancer risk were observed among postmenopausal subjects who consumed more than 0.101 g of EPA (OR [95% CI]: 0.38 [0.15 to 0.96]) and 0.213 g of DHA (OR [95% CI]: 0.32 [0.13 to 0.82]) from fish per day compared to the reference group who consumed less than 0.014 g of EPA and 0.037 g of DHA per day. Among premenopausal women, there was a significant reduction in breast cancer risk for the highest intake quartiles of omega-3 fatty acids (ORs [95% CI]: 0.46 [0.22 to 0.96]), compared to the reference group who consumed the lowest quartile of intake.

CONCLUSION

These results suggest that high consumption of fatty fish is associated with a reduced risk for breast cancer, and that the intake of omega-3 fatty acids from fish is inversely associated with postmenopausal breast cancer risk.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Cancer Epidemiology Branch, Division of Cancer Epidemiology and Management, Research Institute, National Cancer Center, Gyeonggi, South Korea. jskim@ncc.re.kr

    , , , , , , ,

    Source

    BMC cancer 9: 2009 Jun 30 pg 216

    MeSH

    Adult
    Aged
    Animals
    Breast Neoplasms
    Case-Control Studies
    Diet
    Docosahexaenoic Acids
    Eicosapentaenoic Acid
    Fatty Acids, Omega-3
    Female
    Fishes
    Humans
    Korea
    Middle Aged
    Odds Ratio
    Seafood

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    19566923

    Citation

    Kim, Jeongseon, et al. "Fatty Fish and Fish Omega-3 Fatty Acid Intakes Decrease the Breast Cancer Risk: a Case-control Study." BMC Cancer, vol. 9, 2009, p. 216.
    Kim J, Lim SY, Shin A, et al. Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study. BMC Cancer. 2009;9:216.
    Kim, J., Lim, S. Y., Shin, A., Sung, M. K., Ro, J., Kang, H. S., ... Lee, E. S. (2009). Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study. BMC Cancer, 9, p. 216. doi:10.1186/1471-2407-9-216.
    Kim J, et al. Fatty Fish and Fish Omega-3 Fatty Acid Intakes Decrease the Breast Cancer Risk: a Case-control Study. BMC Cancer. 2009 Jun 30;9:216. PubMed PMID: 19566923.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study. AU - Kim,Jeongseon, AU - Lim,Sun-Young, AU - Shin,Aesun, AU - Sung,Mi-Kyung, AU - Ro,Jungsil, AU - Kang,Han-Sung, AU - Lee,Keun Seok, AU - Kim,Seok-Won, AU - Lee,Eun-Sook, Y1 - 2009/06/30/ PY - 2009/01/08/received PY - 2009/06/30/accepted PY - 2009/7/2/entrez PY - 2009/7/2/pubmed PY - 2009/12/16/medline SP - 216 EP - 216 JF - BMC cancer JO - BMC Cancer VL - 9 N2 - BACKGROUND: Although it is believed that fish omega-3 fatty acids may decrease breast cancer risk, epidemiological evidence has been inconclusive. This study examined the association between fish and fish omega-3 fatty acids intake with the risk of breast cancer in a case-control study of Korean women. METHODS: We recruited 358 incident breast cancer patients and 360 controls with no history of malignant neoplasm from the National Cancer Center Hospital between July 2007 and April 2008. The study participants were given a 103-item food intake frequency questionnaire to determine their dietary consumption of fish (fatty and lean fish) and omega-3 fatty acids derived from fish (eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA)). RESULTS: Using a multivariate logistic regression model, high intake of fatty fish was associated with a reduced risk for breast cancer in both pre- and postmenopausal women (OR [95% CI] for highest vs. lowest intake quartiles, p for trend: 0.19 [0.08 to 0.45], p < 0.001 for premenopausal women, 0.27 [0.11 to 0.66], p = 0.005 for postmenopausal women). Similarly, reductions in breast cancer risk were observed among postmenopausal subjects who consumed more than 0.101 g of EPA (OR [95% CI]: 0.38 [0.15 to 0.96]) and 0.213 g of DHA (OR [95% CI]: 0.32 [0.13 to 0.82]) from fish per day compared to the reference group who consumed less than 0.014 g of EPA and 0.037 g of DHA per day. Among premenopausal women, there was a significant reduction in breast cancer risk for the highest intake quartiles of omega-3 fatty acids (ORs [95% CI]: 0.46 [0.22 to 0.96]), compared to the reference group who consumed the lowest quartile of intake. CONCLUSION: These results suggest that high consumption of fatty fish is associated with a reduced risk for breast cancer, and that the intake of omega-3 fatty acids from fish is inversely associated with postmenopausal breast cancer risk. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/19566923/Fatty_fish_and_fish_omega_3_fatty_acid_intakes_decrease_the_breast_cancer_risk:_a_case_control_study_ L2 - https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-9-216 DB - PRIME DP - Unbound Medicine ER -