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Anthropometry and esophageal cancer risk in the European prospective investigation into cancer and nutrition.
Cancer Epidemiol Biomarkers Prev 2009; 18(7):2079-89CE

Abstract

BACKGROUND

Increasing evidence suggests that general obesity [measured by body mass index (BMI)] is positively associated with risk of esophageal adenocarcinoma (EAC). In contrast, previous studies have shown inverse relations with esophageal squamous cell carcinoma (ESCC). However, it is still unclear whether body fat distribution, particularly abdominal obesity, is associated with each type of esophageal cancer.

METHODS

We applied multivariable adjusted Cox proportional hazards regression to investigate the association between anthropometric measures and risk of EAC and ESCC among 346,554 men and women participating in the European Prospective Investigation into Cancer and Nutrition. All statistical tests were two sided.

RESULTS

During 8.9 years of follow-up, we documented 88 incident cases of EAC and 110 cases of ESCC. BMI, waist circumference, and waist-to-hip ratio (WHR) were positively associated with EAC risk [highest versus lowest quintile; relative risk (RR), 2.60; 95% confidence interval (95% CI), 1.23-5.51; P(trend) < 0.01; RR, 3.07; 95% CI, 1.35-6.98; P(trend) < 0.003; and RR, 2.12; 95% CI, 0.98-4.57; P(trend) < 0.004]. In contrast, BMI and waist circumference were inversely related to ESCC risk, whereas WHR showed no association with ESCC. In stratified analyses, BMI and waist circumference were significantly inversely related to ESCC only among smokers but not among nonsmokers. However, when controlled for BMI, we found positive associations for waist circumference and WHR with ESCC, and these associations were observed among smokers and nonsmokers.

CONCLUSION

General and abdominal obesity were associated with higher EAC risk. Further, our study suggests that particularly an abdominal body fat distribution might also be a risk factor for ESCC.

Authors+Show Affiliations

Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. annika.steffen@dife.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19567501

Citation

Steffen, Annika, et al. "Anthropometry and Esophageal Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 18, no. 7, 2009, pp. 2079-89.
Steffen A, Schulze MB, Pischon T, et al. Anthropometry and esophageal cancer risk in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev. 2009;18(7):2079-89.
Steffen, A., Schulze, M. B., Pischon, T., Dietrich, T., Molina, E., Chirlaque, M. D., ... Boeing, H. (2009). Anthropometry and esophageal cancer risk in the European prospective investigation into cancer and nutrition. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 18(7), pp. 2079-89. doi:10.1158/1055-9965.EPI-09-0265.
Steffen A, et al. Anthropometry and Esophageal Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition. Cancer Epidemiol Biomarkers Prev. 2009;18(7):2079-89. PubMed PMID: 19567501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anthropometry and esophageal cancer risk in the European prospective investigation into cancer and nutrition. AU - Steffen,Annika, AU - Schulze,Matthias B, AU - Pischon,Tobias, AU - Dietrich,Thomas, AU - Molina,Esther, AU - Chirlaque,Maria-Dolores, AU - Barricarte,Aurelio, AU - Amiano,Pilar, AU - Quirós,J Ramón, AU - Tumino,Rosario, AU - Mattiello,Amalia, AU - Palli,Domenico, AU - Vineis,Paolo, AU - Agnoli,Claudia, AU - Misirli,Gesthimani, AU - Boffetta,Paolo, AU - Kaaks,Rudolf, AU - Rohrmann,Sabine, AU - Bueno-de-Mesquita,H Bas, AU - Peeters,Petra H M, AU - May,Anne M, AU - Spencer,Elizabeth A, AU - Allen,Naomi E, AU - Bingham,Sheila, AU - Tjønneland,Anne, AU - Halkjaer,Jytte, AU - Overvad,Kim, AU - Stegger,Jakob, AU - Manjer,Jonas, AU - Lindkvist,Björn, AU - Hallmanns,Göran, AU - Stenling,Roger, AU - Lund,Eiliv, AU - Riboli,Elio, AU - Gonzalez,Carlos A, AU - Boeing,Heiner, Y1 - 2009/06/30/ PY - 2009/7/2/entrez PY - 2009/7/2/pubmed PY - 2009/10/9/medline SP - 2079 EP - 89 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 18 IS - 7 N2 - BACKGROUND: Increasing evidence suggests that general obesity [measured by body mass index (BMI)] is positively associated with risk of esophageal adenocarcinoma (EAC). In contrast, previous studies have shown inverse relations with esophageal squamous cell carcinoma (ESCC). However, it is still unclear whether body fat distribution, particularly abdominal obesity, is associated with each type of esophageal cancer. METHODS: We applied multivariable adjusted Cox proportional hazards regression to investigate the association between anthropometric measures and risk of EAC and ESCC among 346,554 men and women participating in the European Prospective Investigation into Cancer and Nutrition. All statistical tests were two sided. RESULTS: During 8.9 years of follow-up, we documented 88 incident cases of EAC and 110 cases of ESCC. BMI, waist circumference, and waist-to-hip ratio (WHR) were positively associated with EAC risk [highest versus lowest quintile; relative risk (RR), 2.60; 95% confidence interval (95% CI), 1.23-5.51; P(trend) < 0.01; RR, 3.07; 95% CI, 1.35-6.98; P(trend) < 0.003; and RR, 2.12; 95% CI, 0.98-4.57; P(trend) < 0.004]. In contrast, BMI and waist circumference were inversely related to ESCC risk, whereas WHR showed no association with ESCC. In stratified analyses, BMI and waist circumference were significantly inversely related to ESCC only among smokers but not among nonsmokers. However, when controlled for BMI, we found positive associations for waist circumference and WHR with ESCC, and these associations were observed among smokers and nonsmokers. CONCLUSION: General and abdominal obesity were associated with higher EAC risk. Further, our study suggests that particularly an abdominal body fat distribution might also be a risk factor for ESCC. SN - 1538-7755 UR - https://www.unboundmedicine.com/medline/citation/19567501/Anthropometry_and_esophageal_cancer_risk_in_the_European_prospective_investigation_into_cancer_and_nutrition_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=19567501 DB - PRIME DP - Unbound Medicine ER -