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The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets.
J Clin Endocrinol Metab. 2009 Sep; 94(9):3314-21.JC

Abstract

CONTEXT

Children with calcium-deficiency rickets have high 1,25-dihydroxyvitamin D values.

OBJECTIVE

The objective of the study was to determine whether vitamin D increased calcium absorption.

DESIGN

This was an experimental study.

SETTING

The study was conducted at a teaching hospital.

PARTICIPANTS

Participants included 17 children with nutritional rickets.

INTERVENTION

The participants were randomized to 1.25 mg oral vitamin D(3) (n = 8) or vitamin D(2) (n = 9).

MAIN OUTCOME MEASURE

Fractional calcium absorption 3 da after vitamin D administration was measured.

RESULTS

Mean baseline 25-hydroxyvitamin D concentrations were 20 ng/ml (range 5-31 ng/ml). The increase in 25-hydroxyvitamin D was equivalent after vitamin D(3) (29 +/- 10 ng/ml) or vitamin D(2) (29 +/- 17 ng/ml). Mean 1,25-dihydroxyvitamin D values increased from 143 +/- 76 pg/ml to 243 +/- 102 pg/ml (P = 0.001), and the increase in 1,25-dihydroxyvitamin D did not differ between vitamin D(2) and vitamin D(3) (107 +/- 110 and 91 +/- 102 ng/ml, respectively). The increment in 1,25-dihydroxyvitamin D was explained almost entirely by the baseline 25-hydroxyvitamin D concentration (r(2) = 0.72; P < 0.001). Mean fractional calcium absorption did not differ before (52.6 +/- 21.4%) or after (53.2 +/- 23.5%) vitamin D, and effects of vitamin D(2) and vitamin D(3) on calcium absorption were not significantly different. Fractional calcium absorption was not closely related to concentrations of 25-hydroxyvitamin D (r = 0.01, P = 0.93) or 1,25-dihydroxyvitamin D (r = 0.21, P = 0.24). The effect of vitamin D on calcium absorption did not vary with baseline 25-hydroxyvitamin D values or with the absolute increase in 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D values.

CONCLUSIONS

Despite similar increases in 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with vitamin D(2) or vitamin D(3), fractional calcium absorption did not increase, indicating that rickets in Nigerian children is not primarily due to vitamin D-deficient calcium malabsorption.

Authors+Show Affiliations

Department of Family Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA. thacher.thomas@mayo.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

19567516

Citation

Thacher, Tom D., et al. "The Effect of Vitamin D2 and Vitamin D3 On Intestinal Calcium Absorption in Nigerian Children With Rickets." The Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 9, 2009, pp. 3314-21.
Thacher TD, Obadofin MO, O'Brien KO, et al. The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets. J Clin Endocrinol Metab. 2009;94(9):3314-21.
Thacher, T. D., Obadofin, M. O., O'Brien, K. O., & Abrams, S. A. (2009). The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets. The Journal of Clinical Endocrinology and Metabolism, 94(9), 3314-21. https://doi.org/10.1210/jc.2009-0018
Thacher TD, et al. The Effect of Vitamin D2 and Vitamin D3 On Intestinal Calcium Absorption in Nigerian Children With Rickets. J Clin Endocrinol Metab. 2009;94(9):3314-21. PubMed PMID: 19567516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets. AU - Thacher,Tom D, AU - Obadofin,Michael O, AU - O'Brien,Kimberly O, AU - Abrams,Steven A, Y1 - 2009/06/30/ PY - 2009/7/2/entrez PY - 2009/7/2/pubmed PY - 2009/9/24/medline SP - 3314 EP - 21 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 94 IS - 9 N2 - CONTEXT: Children with calcium-deficiency rickets have high 1,25-dihydroxyvitamin D values. OBJECTIVE: The objective of the study was to determine whether vitamin D increased calcium absorption. DESIGN: This was an experimental study. SETTING: The study was conducted at a teaching hospital. PARTICIPANTS: Participants included 17 children with nutritional rickets. INTERVENTION: The participants were randomized to 1.25 mg oral vitamin D(3) (n = 8) or vitamin D(2) (n = 9). MAIN OUTCOME MEASURE: Fractional calcium absorption 3 da after vitamin D administration was measured. RESULTS: Mean baseline 25-hydroxyvitamin D concentrations were 20 ng/ml (range 5-31 ng/ml). The increase in 25-hydroxyvitamin D was equivalent after vitamin D(3) (29 +/- 10 ng/ml) or vitamin D(2) (29 +/- 17 ng/ml). Mean 1,25-dihydroxyvitamin D values increased from 143 +/- 76 pg/ml to 243 +/- 102 pg/ml (P = 0.001), and the increase in 1,25-dihydroxyvitamin D did not differ between vitamin D(2) and vitamin D(3) (107 +/- 110 and 91 +/- 102 ng/ml, respectively). The increment in 1,25-dihydroxyvitamin D was explained almost entirely by the baseline 25-hydroxyvitamin D concentration (r(2) = 0.72; P < 0.001). Mean fractional calcium absorption did not differ before (52.6 +/- 21.4%) or after (53.2 +/- 23.5%) vitamin D, and effects of vitamin D(2) and vitamin D(3) on calcium absorption were not significantly different. Fractional calcium absorption was not closely related to concentrations of 25-hydroxyvitamin D (r = 0.01, P = 0.93) or 1,25-dihydroxyvitamin D (r = 0.21, P = 0.24). The effect of vitamin D on calcium absorption did not vary with baseline 25-hydroxyvitamin D values or with the absolute increase in 25-hydroxyvitamin D or 1,25-dihydroxyvitamin D values. CONCLUSIONS: Despite similar increases in 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with vitamin D(2) or vitamin D(3), fractional calcium absorption did not increase, indicating that rickets in Nigerian children is not primarily due to vitamin D-deficient calcium malabsorption. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/19567516/The_effect_of_vitamin_D2_and_vitamin_D3_on_intestinal_calcium_absorption_in_Nigerian_children_with_rickets_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2009-0018 DB - PRIME DP - Unbound Medicine ER -