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Fish oil and heart health.
J Cardiovasc Pharmacol. 2009 Nov; 54(5):378-384.JC

Abstract

Large controlled trials have shown that intake of fish oil (marine n-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid), whether from dietary sources or fish oil supplements, may exhibit beneficial effects on total and cardiovascular disease mortality. Stabilization of cell membranes and suppression of cardiac arrhythmias have been identified as possible mechanisms. Moreover, n-3 fatty acids have anti-inflammatory effects, reduce blood pressure, and may also be antiatherogenic. Finally, high doses of n-3 fatty acids can lower elevated serum triglyceride levels. The n-3 index (erythrocyte eicosapentaenoic acid plus docosahexaenoic acid) may be considered as a potential risk marker for coronary heart disease mortality, especially sudden cardiac death. The balance of n-6 to n-3 fatty acids is an important determinant in decreasing the risk for coronary heart disease, both in the primary and in the secondary prevention of coronary heart disease. Patients with known coronary heart disease should be recommended to consume n-3 fatty acid supplements at 1 g per day, without raising concerns for interactions with other medications or side effects. On the other hand, fish in the diet (preferably oily fish, 1-2 meals/week) should be considered as part of a healthy diet low in saturated fat.

Authors+Show Affiliations

Coeur et Nutrition, Université de Grenoble, La Tronche, France. joel.deleiris@ujf-grenoble.frNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

19568180

Citation

de Leiris, Joël, et al. "Fish Oil and Heart Health." Journal of Cardiovascular Pharmacology, vol. 54, no. 5, 2009, pp. 378-384.
de Leiris J, de Lorgeril M, Boucher F. Fish oil and heart health. J Cardiovasc Pharmacol. 2009;54(5):378-384.
de Leiris, J., de Lorgeril, M., & Boucher, F. (2009). Fish oil and heart health. Journal of Cardiovascular Pharmacology, 54(5), 378-384. https://doi.org/10.1097/FJC.0b013e3181af6c56
de Leiris J, de Lorgeril M, Boucher F. Fish Oil and Heart Health. J Cardiovasc Pharmacol. 2009;54(5):378-384. PubMed PMID: 19568180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish oil and heart health. AU - de Leiris,Joël, AU - de Lorgeril,Michel, AU - Boucher,François, PY - 2009/7/2/entrez PY - 2009/7/2/pubmed PY - 2010/4/10/medline SP - 378 EP - 384 JF - Journal of cardiovascular pharmacology JO - J. Cardiovasc. Pharmacol. VL - 54 IS - 5 N2 - Large controlled trials have shown that intake of fish oil (marine n-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid), whether from dietary sources or fish oil supplements, may exhibit beneficial effects on total and cardiovascular disease mortality. Stabilization of cell membranes and suppression of cardiac arrhythmias have been identified as possible mechanisms. Moreover, n-3 fatty acids have anti-inflammatory effects, reduce blood pressure, and may also be antiatherogenic. Finally, high doses of n-3 fatty acids can lower elevated serum triglyceride levels. The n-3 index (erythrocyte eicosapentaenoic acid plus docosahexaenoic acid) may be considered as a potential risk marker for coronary heart disease mortality, especially sudden cardiac death. The balance of n-6 to n-3 fatty acids is an important determinant in decreasing the risk for coronary heart disease, both in the primary and in the secondary prevention of coronary heart disease. Patients with known coronary heart disease should be recommended to consume n-3 fatty acid supplements at 1 g per day, without raising concerns for interactions with other medications or side effects. On the other hand, fish in the diet (preferably oily fish, 1-2 meals/week) should be considered as part of a healthy diet low in saturated fat. SN - 1533-4023 UR - https://www.unboundmedicine.com/medline/citation/19568180/Fish_oil_and_heart_health_ L2 - http://dx.doi.org/10.1097/FJC.0b013e3181af6c56 DB - PRIME DP - Unbound Medicine ER -