TY - JOUR T1 - Relationship between various Chinese medicine types and T-cell subsets in patients with ulcerative colitis. AU - Chang,Ting-min, AU - Li,Xiu-min, AU - Zhao,Xi-de, Y1 - 2009/07/02/ PY - 2008/08/01/received PY - 2009/7/2/entrez PY - 2009/7/2/pubmed PY - 2009/8/1/medline SP - 220 EP - 3 JF - Chinese journal of integrative medicine JO - Chin J Integr Med VL - 15 IS - 3 N2 - OBJECTIVE: To investigate the relationship between various Chinese medicine (CM) types and T-cell subsets (CD4(+) and CD8(+)) in the colonic mucous membranes of patients with ulcerative colitis (UC). METHODS: Fifty UC patients were enrolled, after differentiation into four types by CM syndromes, i.e., the internal heat-damp accumulation type (IHDA), the qi-stagnancy with blood stasis type (QSBS), the Pi-Shen yang-deficiency type (PSYD) and the yin-blood deficiency type (YBD). From every patient, 3-5 pieces of intestinal mucous membrane tissues were taken through colonoscopy to determine the levels of the T-cell subsets (CD4(+) and CD8(+)) using immunohistochemical method. The results were compared with those in the normal control. RESULTS: The level of CD8(+)increased and the ratio of CD4(+)/CD8(+)decreased mainly in colonic mucous membranous tissues in UC patients. The level of CD4(+)decreased significantly in IHDA types (P<0.01), but decreased only slightly in the PSYD, QSBS and YBD types. CD8(+)increased significantly in the IHDA types (P<0.01), but only slightly in the other three types. CONCLUSION: The IHDA types of UC are closely related with T-cell subsets. The difference of T-cell subsets in various IHDA types of UC patients has provided a theoretical basis for syndrome differentiation in the CM typing of UC. SN - 1672-0415 UR - https://www.unboundmedicine.com/medline/citation/19568716/Relationship_between_various_Chinese_medicine_types_and_T_cell_subsets_in_patients_with_ulcerative_colitis_ L2 - https://dx.doi.org/10.1007/s11655-009-0220-y DB - PRIME DP - Unbound Medicine ER -