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Relationship between various Chinese medicine types and T-cell subsets in patients with ulcerative colitis.
Chin J Integr Med. 2009 Jun; 15(3):220-3.CJ

Abstract

OBJECTIVE

To investigate the relationship between various Chinese medicine (CM) types and T-cell subsets (CD4(+) and CD8(+)) in the colonic mucous membranes of patients with ulcerative colitis (UC).

METHODS

Fifty UC patients were enrolled, after differentiation into four types by CM syndromes, i.e., the internal heat-damp accumulation type (IHDA), the qi-stagnancy with blood stasis type (QSBS), the Pi-Shen yang-deficiency type (PSYD) and the yin-blood deficiency type (YBD). From every patient, 3-5 pieces of intestinal mucous membrane tissues were taken through colonoscopy to determine the levels of the T-cell subsets (CD4(+) and CD8(+)) using immunohistochemical method. The results were compared with those in the normal control.

RESULTS

The level of CD8(+)increased and the ratio of CD4(+)/CD8(+)decreased mainly in colonic mucous membranous tissues in UC patients. The level of CD4(+)decreased significantly in IHDA types (P<0.01), but decreased only slightly in the PSYD, QSBS and YBD types. CD8(+)increased significantly in the IHDA types (P<0.01), but only slightly in the other three types.

CONCLUSION

The IHDA types of UC are closely related with T-cell subsets. The difference of T-cell subsets in various IHDA types of UC patients has provided a theoretical basis for syndrome differentiation in the CM typing of UC.

Authors+Show Affiliations

Department of Internal Digestive Medicine, First Affiliated Hospital of Xinxiang Medical College, Henan 453100, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

19568716

Citation

Chang, Ting-min, et al. "Relationship Between Various Chinese Medicine Types and T-cell Subsets in Patients With Ulcerative Colitis." Chinese Journal of Integrative Medicine, vol. 15, no. 3, 2009, pp. 220-3.
Chang TM, Li XM, Zhao XD. Relationship between various Chinese medicine types and T-cell subsets in patients with ulcerative colitis. Chin J Integr Med. 2009;15(3):220-3.
Chang, T. M., Li, X. M., & Zhao, X. D. (2009). Relationship between various Chinese medicine types and T-cell subsets in patients with ulcerative colitis. Chinese Journal of Integrative Medicine, 15(3), 220-3. https://doi.org/10.1007/s11655-009-0220-y
Chang TM, Li XM, Zhao XD. Relationship Between Various Chinese Medicine Types and T-cell Subsets in Patients With Ulcerative Colitis. Chin J Integr Med. 2009;15(3):220-3. PubMed PMID: 19568716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between various Chinese medicine types and T-cell subsets in patients with ulcerative colitis. AU - Chang,Ting-min, AU - Li,Xiu-min, AU - Zhao,Xi-de, Y1 - 2009/07/02/ PY - 2008/08/01/received PY - 2009/7/2/entrez PY - 2009/7/2/pubmed PY - 2009/8/1/medline SP - 220 EP - 3 JF - Chinese journal of integrative medicine JO - Chin J Integr Med VL - 15 IS - 3 N2 - OBJECTIVE: To investigate the relationship between various Chinese medicine (CM) types and T-cell subsets (CD4(+) and CD8(+)) in the colonic mucous membranes of patients with ulcerative colitis (UC). METHODS: Fifty UC patients were enrolled, after differentiation into four types by CM syndromes, i.e., the internal heat-damp accumulation type (IHDA), the qi-stagnancy with blood stasis type (QSBS), the Pi-Shen yang-deficiency type (PSYD) and the yin-blood deficiency type (YBD). From every patient, 3-5 pieces of intestinal mucous membrane tissues were taken through colonoscopy to determine the levels of the T-cell subsets (CD4(+) and CD8(+)) using immunohistochemical method. The results were compared with those in the normal control. RESULTS: The level of CD8(+)increased and the ratio of CD4(+)/CD8(+)decreased mainly in colonic mucous membranous tissues in UC patients. The level of CD4(+)decreased significantly in IHDA types (P<0.01), but decreased only slightly in the PSYD, QSBS and YBD types. CD8(+)increased significantly in the IHDA types (P<0.01), but only slightly in the other three types. CONCLUSION: The IHDA types of UC are closely related with T-cell subsets. The difference of T-cell subsets in various IHDA types of UC patients has provided a theoretical basis for syndrome differentiation in the CM typing of UC. SN - 1672-0415 UR - https://www.unboundmedicine.com/medline/citation/19568716/Relationship_between_various_Chinese_medicine_types_and_T_cell_subsets_in_patients_with_ulcerative_colitis_ L2 - https://dx.doi.org/10.1007/s11655-009-0220-y DB - PRIME DP - Unbound Medicine ER -