Prime

Type your tag names separated by a space and hit enter

Characterization of dextrin-based hydrogels: rheology, biocompatibility, and degradation.

Abstract

A new class of degradable dextrin-based hydrogels (dextrin-HEMA) was developed. The hydroxyethyl methacrylate ester (HEMA) hydroxyl groups were activated with N,N'-carbonyldiimidazole (CDI), followed by their coupling to dextrin, yielding a derivatized material that can be polymerized in aqueous solution to form hydrogels. A comparative study of the stability of the dextrin-HEMA hydrogels and dextrin-vinyl acrylate (dextrin-VA, produced in previous work) revealed that only the firsts are effectively hydrolyzed under physiological conditions. A severe mass loss of dextrin-HEMA gels occurs over time, culminating in the complete dissolution of the gels. Rheologic analysis confirmed that physical structuring is less pronounced when dextrin is modified with methacrylate side groups. The biocompatibility results revealed that the dextrin hydrogels have negligible cell toxicity, irrespective of the hydrogel type (HEMA and VA), allowing cell adhesion and proliferation. Gathering the biocompatibility and the ability to tailor the release profiles, we consider dextrin a promising biomaterial for biomedical applications, namely for controlled release.

Links

  • Publisher Full Text
  • Authors

    , , ,

    Source

    MeSH

    3T3 Cells
    Animals
    Biocompatible Materials
    Cell Adhesion
    Cell Proliferation
    Cells, Cultured
    Dextrins
    Embryo, Mammalian
    Fibroblasts
    Fluorescence
    Hydrogels
    Imidazoles
    Magnetic Resonance Spectroscopy
    Materials Testing
    Mechanical Phenomena
    Methacrylates
    Mice
    Rheology

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    19569221

    Citation

    TY - JOUR T1 - Characterization of dextrin-based hydrogels: rheology, biocompatibility, and degradation. AU - Carvalho,Joana, AU - Moreira,Susana, AU - Maia,João, AU - Gama,Francisco M, PY - 2009/7/2/entrez PY - 2009/7/2/pubmed PY - 2010/5/19/medline SP - 389 EP - 99 JF - Journal of biomedical materials research. Part A JO - J Biomed Mater Res A VL - 93 IS - 1 N2 - A new class of degradable dextrin-based hydrogels (dextrin-HEMA) was developed. The hydroxyethyl methacrylate ester (HEMA) hydroxyl groups were activated with N,N'-carbonyldiimidazole (CDI), followed by their coupling to dextrin, yielding a derivatized material that can be polymerized in aqueous solution to form hydrogels. A comparative study of the stability of the dextrin-HEMA hydrogels and dextrin-vinyl acrylate (dextrin-VA, produced in previous work) revealed that only the firsts are effectively hydrolyzed under physiological conditions. A severe mass loss of dextrin-HEMA gels occurs over time, culminating in the complete dissolution of the gels. Rheologic analysis confirmed that physical structuring is less pronounced when dextrin is modified with methacrylate side groups. The biocompatibility results revealed that the dextrin hydrogels have negligible cell toxicity, irrespective of the hydrogel type (HEMA and VA), allowing cell adhesion and proliferation. Gathering the biocompatibility and the ability to tailor the release profiles, we consider dextrin a promising biomaterial for biomedical applications, namely for controlled release. SN - 1552-4965 UR - https://www.unboundmedicine.com/medline/citation/19569221/Characterization_of_dextrin_based_hydrogels:_rheology_biocompatibility_and_degradation_ L2 - http://dx.doi.org/10.1002/jbm.a.32553 ER -