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Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature.
Int J Clin Pract. 2009 Jul; 63(7):1061-7.IJ

Abstract

Elevated serum homocysteine, decreased folate and low vitamin B(12) serum levels are associated with poor cognitive function, cognitive decline and dementia. Despite evidence of an epidemiological association, randomised controlled trials did not provide any clear evidence so far that supplementation with vitamin B(12) and/or folate improves dementia or slows cognitive decline, even though it might normalise homocysteine levels. In this report, we review the current knowledge on the relationship between homocysteine, folate and vitamin B(12) levels and the way their disruption influences cognitive function in adults.

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Authors+Show Affiliations

Vogel T
Pôle de Gériatrie, Hôpitaux Universitaires de Strasbourg, Hôpital de la Robertsau, Pavillon Schutzenberger, Strasbourg Cedex, France.
Dali-Youcef N
No affiliation info available
Kaltenbach G
No affiliation info available
Andrès E
No affiliation info available

MeSH

AdultClinical Trials as TopicCognition DisordersCross-Sectional StudiesDietary SupplementsFolic AcidHomocysteineHumansLongitudinal StudiesVitamin B 12Vitamin B 12 DeficiencyVitamin B Complex

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

19570123

Citation

Vogel, T, et al. "Homocysteine, Vitamin B12, Folate and Cognitive Functions: a Systematic and Critical Review of the Literature." International Journal of Clinical Practice, vol. 63, no. 7, 2009, pp. 1061-7.
Vogel T, Dali-Youcef N, Kaltenbach G, et al. Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature. Int J Clin Pract. 2009;63(7):1061-7.
Vogel, T., Dali-Youcef, N., Kaltenbach, G., & Andrès, E. (2009). Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature. International Journal of Clinical Practice, 63(7), 1061-7. https://doi.org/10.1111/j.1742-1241.2009.02026.x
Vogel T, et al. Homocysteine, Vitamin B12, Folate and Cognitive Functions: a Systematic and Critical Review of the Literature. Int J Clin Pract. 2009;63(7):1061-7. PubMed PMID: 19570123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature. AU - Vogel,T, AU - Dali-Youcef,N, AU - Kaltenbach,G, AU - Andrès,E, PY - 2009/7/3/entrez PY - 2009/7/3/pubmed PY - 2010/11/3/medline SP - 1061 EP - 7 JF - International journal of clinical practice JO - Int J Clin Pract VL - 63 IS - 7 N2 - Elevated serum homocysteine, decreased folate and low vitamin B(12) serum levels are associated with poor cognitive function, cognitive decline and dementia. Despite evidence of an epidemiological association, randomised controlled trials did not provide any clear evidence so far that supplementation with vitamin B(12) and/or folate improves dementia or slows cognitive decline, even though it might normalise homocysteine levels. In this report, we review the current knowledge on the relationship between homocysteine, folate and vitamin B(12) levels and the way their disruption influences cognitive function in adults. SN - 1742-1241 UR - https://www.unboundmedicine.com/medline/citation/19570123/Homocysteine_vitamin_B12_folate_and_cognitive_functions:_a_systematic_and_critical_review_of_the_literature_ L2 - https://doi.org/10.1111/j.1742-1241.2009.02026.x DB - PRIME DP - Unbound Medicine ER -