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Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi.
Fungal Genet Biol. 2009 Apr; 46(4):287-98.FG

Abstract

Mitogen-activated protein kinase (MAPK) cascades and the calcium-calcineurin pathway control fundamental aspects of fungal growth, development and reproduction. Core elements of these signalling pathways are required for virulence in a wide array of fungal pathogens of plants and mammals. In this review, we have used the available genome databases to explore the structural conservation of three MAPK cascades and the calcium-calcineurin pathway in ten different fungal species, including model organisms, plant pathogens and human pathogens. While most known pathway components from the model yeast Saccharomyces cerevisiae appear to be widely conserved among taxonomically and biologically diverse fungi, some of them were found to be restricted to the Saccharomycotina. The presence of multiple paralogues in certain species such as the zygomycete Rhizopus oryzae and the incorporation of new functional domains that are lacking in S. cerevisiae signalling proteins, most likely reflect functional diversification or adaptation as filamentous fungi have evolved to occupy distinct ecological niches.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Rispail N
Departamento de Genética, Universidad de Córdoba, Córdoba, Spain.
Soanes DM
No affiliation info available
Ant C
No affiliation info available
Czajkowski R
No affiliation info available
Grünler A
No affiliation info available
Huguet R
No affiliation info available
Perez-Nadales E
No affiliation info available
Poli A
No affiliation info available
Sartorel E
No affiliation info available
Valiante V
No affiliation info available
Yang M
No affiliation info available
Beffa R
No affiliation info available
Brakhage AA
No affiliation info available
Gow NA
No affiliation info available
Kahmann R
No affiliation info available
Lebrun MH
No affiliation info available
Lenasi H
No affiliation info available
Perez-Martin J
No affiliation info available
Talbot NJ
No affiliation info available
Wendland J
No affiliation info available
Di Pietro A
No affiliation info available

MeSH

CalcineurinCalciumFungal ProteinsFungiGenomicsHumansMAP Kinase Signaling SystemMycosesPlant DiseasesPlantsProtein KinasesSignal Transduction

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

19570501

Citation

Rispail, Nicolas, et al. "Comparative Genomics of MAP Kinase and Calcium-calcineurin Signalling Components in Plant and Human Pathogenic Fungi." Fungal Genetics and Biology : FG & B, vol. 46, no. 4, 2009, pp. 287-98.
Rispail N, Soanes DM, Ant C, et al. Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi. Fungal Genet Biol. 2009;46(4):287-98.
Rispail, N., Soanes, D. M., Ant, C., Czajkowski, R., Grünler, A., Huguet, R., Perez-Nadales, E., Poli, A., Sartorel, E., Valiante, V., Yang, M., Beffa, R., Brakhage, A. A., Gow, N. A., Kahmann, R., Lebrun, M. H., Lenasi, H., Perez-Martin, J., Talbot, N. J., ... Di Pietro, A. (2009). Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi. Fungal Genetics and Biology : FG & B, 46(4), 287-98. https://doi.org/10.1016/j.fgb.2009.01.002
Rispail N, et al. Comparative Genomics of MAP Kinase and Calcium-calcineurin Signalling Components in Plant and Human Pathogenic Fungi. Fungal Genet Biol. 2009;46(4):287-98. PubMed PMID: 19570501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi. AU - Rispail,Nicolas, AU - Soanes,Darren M, AU - Ant,Cemile, AU - Czajkowski,Robert, AU - Grünler,Anke, AU - Huguet,Romain, AU - Perez-Nadales,Elena, AU - Poli,Anna, AU - Sartorel,Elodie, AU - Valiante,Vito, AU - Yang,Meng, AU - Beffa,Roland, AU - Brakhage,Axel A, AU - Gow,Neil A R, AU - Kahmann,Regine, AU - Lebrun,Marc-Henri, AU - Lenasi,Helena, AU - Perez-Martin,José, AU - Talbot,Nicholas J, AU - Wendland,Jürgen, AU - Di Pietro,Antonio, Y1 - 2009/02/07/ PY - 2008/11/25/received PY - 2009/01/16/revised PY - 2009/01/17/accepted PY - 2009/7/3/entrez PY - 2009/7/3/pubmed PY - 2009/8/27/medline SP - 287 EP - 98 JF - Fungal genetics and biology : FG & B JO - Fungal Genet Biol VL - 46 IS - 4 N2 - Mitogen-activated protein kinase (MAPK) cascades and the calcium-calcineurin pathway control fundamental aspects of fungal growth, development and reproduction. Core elements of these signalling pathways are required for virulence in a wide array of fungal pathogens of plants and mammals. In this review, we have used the available genome databases to explore the structural conservation of three MAPK cascades and the calcium-calcineurin pathway in ten different fungal species, including model organisms, plant pathogens and human pathogens. While most known pathway components from the model yeast Saccharomyces cerevisiae appear to be widely conserved among taxonomically and biologically diverse fungi, some of them were found to be restricted to the Saccharomycotina. The presence of multiple paralogues in certain species such as the zygomycete Rhizopus oryzae and the incorporation of new functional domains that are lacking in S. cerevisiae signalling proteins, most likely reflect functional diversification or adaptation as filamentous fungi have evolved to occupy distinct ecological niches. SN - 1096-0937 UR - https://www.unboundmedicine.com/medline/citation/19570501/Comparative_genomics_of_MAP_kinase_and_calcium_calcineurin_signalling_components_in_plant_and_human_pathogenic_fungi_ DB - PRIME DP - Unbound Medicine ER -