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Impaired protection against diabetes and coronary heart disease by high-density lipoproteins in Turks.
Metabolism. 2009 Oct; 58(10):1393-9.M

Abstract

The issue of whether or not incident type 2 diabetes mellitus and coronary heart disease (CHD) can be predicted by high-density lipoprotein (HDL) cholesterol in both sexes needs investigation. A representative sample of 3035 middle-aged Turkish adults free of CHD at baseline was studied with this purpose prospectively over a mean of 7.8 years. High-density lipoprotein cholesterol levels were found to be correlated in women positively with plasma fibrinogen and weakly with waist girth and C-reactive protein, and to be not correlated with fasting insulin. High-density lipoprotein cholesterol protected men against future CHD risk (for a 12-mg/dL increment: relative risk = 0.80 [95% confidence interval, 0.69-0.95]) after multivariable adjustment in logistic regression analyses for age, smoking status, physical activity grade, hypertension, abdominal obesity, diabetes, and lipid-lowering drugs. However, men were not protected against risk of diabetes. In women, HDL cholesterol was not associated with risk for CHD, whereas intermediate (40-60 mg/dL) compared with lower HDL cholesterol levels proved protective against risk of diabetes (relative risk = 0.57 [95% confidence interval, 0.36-0.90]) after adjustments that included apolipoprotein A-I tertiles. Yet higher serum concentrations failed to yield protection against diabetes. It was concluded that HDL particles confer partially lacking protection against cardiometabolic risk among Turks, and this impairment is modulated by sex. This highly important observation may result from a setting of prevailing chronic subclinical inflammation.

Authors+Show Affiliations

Turkish Society of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul 34384, Turkey. alt_onat@yahoo.com.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19570555

Citation

Onat, Altan, et al. "Impaired Protection Against Diabetes and Coronary Heart Disease By High-density Lipoproteins in Turks." Metabolism: Clinical and Experimental, vol. 58, no. 10, 2009, pp. 1393-9.
Onat A, Can G, Ayhan E, et al. Impaired protection against diabetes and coronary heart disease by high-density lipoproteins in Turks. Metabolism. 2009;58(10):1393-9.
Onat, A., Can, G., Ayhan, E., Kaya, Z., & Hergenç, G. (2009). Impaired protection against diabetes and coronary heart disease by high-density lipoproteins in Turks. Metabolism: Clinical and Experimental, 58(10), 1393-9. https://doi.org/10.1016/j.metabol.2009.05.004
Onat A, et al. Impaired Protection Against Diabetes and Coronary Heart Disease By High-density Lipoproteins in Turks. Metabolism. 2009;58(10):1393-9. PubMed PMID: 19570555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impaired protection against diabetes and coronary heart disease by high-density lipoproteins in Turks. AU - Onat,Altan, AU - Can,Günay, AU - Ayhan,Erkan, AU - Kaya,Zekeriya, AU - Hergenç,Gülay, Y1 - 2009/07/01/ PY - 2009/02/16/received PY - 2009/04/27/revised PY - 2009/05/07/accepted PY - 2009/7/3/entrez PY - 2009/7/3/pubmed PY - 2009/10/10/medline SP - 1393 EP - 9 JF - Metabolism: clinical and experimental JO - Metabolism VL - 58 IS - 10 N2 - The issue of whether or not incident type 2 diabetes mellitus and coronary heart disease (CHD) can be predicted by high-density lipoprotein (HDL) cholesterol in both sexes needs investigation. A representative sample of 3035 middle-aged Turkish adults free of CHD at baseline was studied with this purpose prospectively over a mean of 7.8 years. High-density lipoprotein cholesterol levels were found to be correlated in women positively with plasma fibrinogen and weakly with waist girth and C-reactive protein, and to be not correlated with fasting insulin. High-density lipoprotein cholesterol protected men against future CHD risk (for a 12-mg/dL increment: relative risk = 0.80 [95% confidence interval, 0.69-0.95]) after multivariable adjustment in logistic regression analyses for age, smoking status, physical activity grade, hypertension, abdominal obesity, diabetes, and lipid-lowering drugs. However, men were not protected against risk of diabetes. In women, HDL cholesterol was not associated with risk for CHD, whereas intermediate (40-60 mg/dL) compared with lower HDL cholesterol levels proved protective against risk of diabetes (relative risk = 0.57 [95% confidence interval, 0.36-0.90]) after adjustments that included apolipoprotein A-I tertiles. Yet higher serum concentrations failed to yield protection against diabetes. It was concluded that HDL particles confer partially lacking protection against cardiometabolic risk among Turks, and this impairment is modulated by sex. This highly important observation may result from a setting of prevailing chronic subclinical inflammation. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/19570555/Impaired_protection_against_diabetes_and_coronary_heart_disease_by_high_density_lipoproteins_in_Turks_ DB - PRIME DP - Unbound Medicine ER -