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Combination of cardiorespiratory reflex parameters and heart rate variability power spectrum analysis for early diagnosis of diabetic cardiac autonomic neuropathy.
Diabetes Metab. 2009 Sep; 35(4):305-11.DM

Abstract

AIM

The study objective was to compare cardiorespiratory reflex (CR-R) parameters and heart rate variability power spectrum (HRV-PS) analysis in the diagnosis of cardiac autonomic neuropathy (CAN) in diabetic patients.

METHODS

Four CR-R tests (Valsalva manoeuvre, deep breathing, and two successive 5-minute periods with the subject supine and standing, respectively) were performed in 399 diabetic patients (58.6% male, median age: 51 years) and 105 healthy controls (40% male, median age: 34 years). Patients with two or more abnormal CR-R parameters were classified as CAN+, while those with only one abnormal CR-R parameter were considered CAN 'borderline'. HRV-PS was performed in all study participants.

RESULTS

The low-frequency (LF) area with the patient standing was reduced in CAN+ diabetics (median 35.6 normalized units [nu], n=31), in CAN 'borderline' diabetics (median 64.3nu, n=70) and even in diabetics without CAN (median 89.4nu, n=298) versus control subjects (median 93.7nu; P<0.001, P<0.001 and P<0.05, respectively). Adding the abnormal (<2.5 nu) LF area to the diagnostic criteria in CAN 'borderline' patients caused 11 (15.7%) patients to be considered CAN+.

CONCLUSION

Combining abnormal CR-R parameters (I - E and I/E the most specific) with HRV-PS (particularly the LF area with the subject standing) allowed diagnosis of diabetic CAN at an earlier stage.

Authors+Show Affiliations

University Department of Medicine and Service of Endocrinology and Nutrition, University Hospital of Santiago, USC, Santiago de Compostela, Spain. jose.cabezas@usc.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

19570704

Citation

Cabezas-Cerrato, J, et al. "Combination of Cardiorespiratory Reflex Parameters and Heart Rate Variability Power Spectrum Analysis for Early Diagnosis of Diabetic Cardiac Autonomic Neuropathy." Diabetes & Metabolism, vol. 35, no. 4, 2009, pp. 305-11.
Cabezas-Cerrato J, Gonzalez-Quintela A, Perez-Rodriguez M, et al. Combination of cardiorespiratory reflex parameters and heart rate variability power spectrum analysis for early diagnosis of diabetic cardiac autonomic neuropathy. Diabetes Metab. 2009;35(4):305-11.
Cabezas-Cerrato, J., Gonzalez-Quintela, A., Perez-Rodriguez, M., Calle, A., Faure-Noguera, E., & Vazquez-Garcia, J. A. (2009). Combination of cardiorespiratory reflex parameters and heart rate variability power spectrum analysis for early diagnosis of diabetic cardiac autonomic neuropathy. Diabetes & Metabolism, 35(4), 305-11. https://doi.org/10.1016/j.diabet.2009.01.006
Cabezas-Cerrato J, et al. Combination of Cardiorespiratory Reflex Parameters and Heart Rate Variability Power Spectrum Analysis for Early Diagnosis of Diabetic Cardiac Autonomic Neuropathy. Diabetes Metab. 2009;35(4):305-11. PubMed PMID: 19570704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of cardiorespiratory reflex parameters and heart rate variability power spectrum analysis for early diagnosis of diabetic cardiac autonomic neuropathy. AU - Cabezas-Cerrato,J, AU - Gonzalez-Quintela,A, AU - Perez-Rodriguez,M, AU - Calle,A, AU - Faure-Noguera,E, AU - Vazquez-Garcia,J A, AU - ,, Y1 - 2009/06/30/ PY - 2008/09/22/received PY - 2009/01/06/revised PY - 2009/01/11/accepted PY - 2009/7/3/entrez PY - 2009/7/3/pubmed PY - 2010/1/9/medline SP - 305 EP - 11 JF - Diabetes & metabolism JO - Diabetes Metab VL - 35 IS - 4 N2 - AIM: The study objective was to compare cardiorespiratory reflex (CR-R) parameters and heart rate variability power spectrum (HRV-PS) analysis in the diagnosis of cardiac autonomic neuropathy (CAN) in diabetic patients. METHODS: Four CR-R tests (Valsalva manoeuvre, deep breathing, and two successive 5-minute periods with the subject supine and standing, respectively) were performed in 399 diabetic patients (58.6% male, median age: 51 years) and 105 healthy controls (40% male, median age: 34 years). Patients with two or more abnormal CR-R parameters were classified as CAN+, while those with only one abnormal CR-R parameter were considered CAN 'borderline'. HRV-PS was performed in all study participants. RESULTS: The low-frequency (LF) area with the patient standing was reduced in CAN+ diabetics (median 35.6 normalized units [nu], n=31), in CAN 'borderline' diabetics (median 64.3nu, n=70) and even in diabetics without CAN (median 89.4nu, n=298) versus control subjects (median 93.7nu; P<0.001, P<0.001 and P<0.05, respectively). Adding the abnormal (<2.5 nu) LF area to the diagnostic criteria in CAN 'borderline' patients caused 11 (15.7%) patients to be considered CAN+. CONCLUSION: Combining abnormal CR-R parameters (I - E and I/E the most specific) with HRV-PS (particularly the LF area with the subject standing) allowed diagnosis of diabetic CAN at an earlier stage. SN - 1878-1780 UR - https://www.unboundmedicine.com/medline/citation/19570704/Combination_of_cardiorespiratory_reflex_parameters_and_heart_rate_variability_power_spectrum_analysis_for_early_diagnosis_of_diabetic_cardiac_autonomic_neuropathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1262-3636(09)00086-X DB - PRIME DP - Unbound Medicine ER -