Di(methylimidazole)prolinol silyl ether catalyzed highly Michael addition of aldehydes to nitroolefins in water.Org Lett. 2009 Aug 06; 11(15):3354-6.OL
Abstract
A new pyrrolidine-based organocatalyst for asymmetric reactions has been developed and shown to be a very effective catalyst for the Michael reaction involving various nitroolefins and aldehydes in water. This design is based on the introduction of a hydrophilic group into the pyrrolidine side chain. This catalyst, di(methylimidazole)prolinol silyl ether in combination with sodium bicarbonate as additive effectively catalyzed the Michael addition of aldehydes to nitroolefins in water as solvent in high yields and excellent enantioselectivities.
Links
Pub Type(s)
Journal Article
Language
eng
PubMed ID
19572597
Citation
Wu, Jianbin, et al. "Di(methylimidazole)prolinol Silyl Ether Catalyzed Highly Michael Addition of Aldehydes to Nitroolefins in Water." Organic Letters, vol. 11, no. 15, 2009, pp. 3354-6.
Wu J, Ni B, Headley AD. Di(methylimidazole)prolinol silyl ether catalyzed highly Michael addition of aldehydes to nitroolefins in water. Org Lett. 2009;11(15):3354-6.
Wu, J., Ni, B., & Headley, A. D. (2009). Di(methylimidazole)prolinol silyl ether catalyzed highly Michael addition of aldehydes to nitroolefins in water. Organic Letters, 11(15), 3354-6. https://doi.org/10.1021/ol901204b
Wu J, Ni B, Headley AD. Di(methylimidazole)prolinol Silyl Ether Catalyzed Highly Michael Addition of Aldehydes to Nitroolefins in Water. Org Lett. 2009 Aug 6;11(15):3354-6. PubMed PMID: 19572597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Di(methylimidazole)prolinol silyl ether catalyzed highly Michael addition of aldehydes to nitroolefins in water.
AU - Wu,Jianbin,
AU - Ni,Bukuo,
AU - Headley,Allan D,
PY - 2009/7/4/entrez
PY - 2009/7/4/pubmed
PY - 2009/7/4/medline
SP - 3354
EP - 6
JF - Organic letters
JO - Org Lett
VL - 11
IS - 15
N2 - A new pyrrolidine-based organocatalyst for asymmetric reactions has been developed and shown to be a very effective catalyst for the Michael reaction involving various nitroolefins and aldehydes in water. This design is based on the introduction of a hydrophilic group into the pyrrolidine side chain. This catalyst, di(methylimidazole)prolinol silyl ether in combination with sodium bicarbonate as additive effectively catalyzed the Michael addition of aldehydes to nitroolefins in water as solvent in high yields and excellent enantioselectivities.
SN - 1523-7052
UR - https://www.unboundmedicine.com/medline/citation/19572597/Di_methylimidazole_prolinol_silyl_ether_catalyzed_highly_Michael_addition_of_aldehydes_to_nitroolefins_in_water_
L2 - https://doi.org/10.1021/ol901204b
DB - PRIME
DP - Unbound Medicine
ER -
