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Alcohol-induced electrical remodeling: effects of sustained short-term ethanol infusion on ion currents in rabbit atrium.
Alcohol Clin Exp Res. 2009 Oct; 33(10):1697-703.AC

Abstract

BACKGROUND

In some patients, above-average alcohol consumption before occurrence of atrial fibrillation (AF) in terms of a "holiday heart syndrome" (HHS) can be determined. There is evidence that long before development of apparent alcohol-induced cardiomyopathy, above-average alcohol consumption generates an arrhythmogenic substrate which abets the onset of AF. Changes of atrial current densities in terms of an electrical remodeling after sustained short-term ethanol infusion in rabbits as a potential part of HHS pathophysiology were examined in this study.

METHODS

Rabbits of the ethanol group (EG) received sustained short-term intravenous alcohol infusion for 120 hours (during infusion period, blood alcohol level did not fall below 158 mg/dl), whereas NaCl 0.9% was infused in the placebo group (PG). Using patch clamp technique in whole-cell mode, atrial current densities were measured and compared between both groups.

RESULTS

Ethanol infusion did not alter current densities of I(to) [58.7 +/- 5.0 pA/pF (PG, n = 20 cells) vs. 53.9 +/- 5.0 pA/pF (EG, n = 24)], I(sus) [11.3 +/- 1.4 pA/pF (PG, n = 20) vs. 10.2 +/- 1.0 pA/pF (EG, n = 24)], and I(K1) [-1.6 +/- 0.3 pA/pF (PG, n = 17) vs. -2.0 +/- 0.3 pA/pF (EG, n = 22)]. However, alcohol infusion resulted in a remarkable reduction of I(Ca,L) current densities [-28.4 +/- 1.8 pA/pF (PG, n = 20) vs. -15.2 +/- 1.4 pA/pF (EG, n = 22)] and I(Na) [-75.4 +/- 3.6 pA/pF (PG, n = 17) vs. -35.4 +/- 4.4 pA/pF (EG, n = 21)], respectively.

CONCLUSION

Sustained short-term ethanol infusion in rabbits alters atrial current densities. HHS might be favored by alcohol-induced atrial electrical remodeling.

Authors+Show Affiliations

Department of Cardiology, University of Tuebingen, Tuebingen, Germany. roman.laszlo@med.uni-tuebingen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

19572985

Citation

Laszlo, Roman, et al. "Alcohol-induced Electrical Remodeling: Effects of Sustained Short-term Ethanol Infusion On Ion Currents in Rabbit Atrium." Alcoholism, Clinical and Experimental Research, vol. 33, no. 10, 2009, pp. 1697-703.
Laszlo R, Eick C, Schwiebert M, et al. Alcohol-induced electrical remodeling: effects of sustained short-term ethanol infusion on ion currents in rabbit atrium. Alcohol Clin Exp Res. 2009;33(10):1697-703.
Laszlo, R., Eick, C., Schwiebert, M., Schreiner, B., Weig, H. J., Weretka, S., Bosch, R. F., & Schreieck, J. (2009). Alcohol-induced electrical remodeling: effects of sustained short-term ethanol infusion on ion currents in rabbit atrium. Alcoholism, Clinical and Experimental Research, 33(10), 1697-703. https://doi.org/10.1111/j.1530-0277.2009.01006.x
Laszlo R, et al. Alcohol-induced Electrical Remodeling: Effects of Sustained Short-term Ethanol Infusion On Ion Currents in Rabbit Atrium. Alcohol Clin Exp Res. 2009;33(10):1697-703. PubMed PMID: 19572985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol-induced electrical remodeling: effects of sustained short-term ethanol infusion on ion currents in rabbit atrium. AU - Laszlo,Roman, AU - Eick,Christian, AU - Schwiebert,Mareike, AU - Schreiner,Birgit, AU - Weig,Hans-Joerg, AU - Weretka,Slawomir, AU - Bosch,Ralph F, AU - Schreieck,Juergen, Y1 - 2009/07/01/ PY - 2009/7/4/entrez PY - 2009/7/4/pubmed PY - 2010/1/12/medline SP - 1697 EP - 703 JF - Alcoholism, clinical and experimental research JO - Alcohol Clin Exp Res VL - 33 IS - 10 N2 - BACKGROUND: In some patients, above-average alcohol consumption before occurrence of atrial fibrillation (AF) in terms of a "holiday heart syndrome" (HHS) can be determined. There is evidence that long before development of apparent alcohol-induced cardiomyopathy, above-average alcohol consumption generates an arrhythmogenic substrate which abets the onset of AF. Changes of atrial current densities in terms of an electrical remodeling after sustained short-term ethanol infusion in rabbits as a potential part of HHS pathophysiology were examined in this study. METHODS: Rabbits of the ethanol group (EG) received sustained short-term intravenous alcohol infusion for 120 hours (during infusion period, blood alcohol level did not fall below 158 mg/dl), whereas NaCl 0.9% was infused in the placebo group (PG). Using patch clamp technique in whole-cell mode, atrial current densities were measured and compared between both groups. RESULTS: Ethanol infusion did not alter current densities of I(to) [58.7 +/- 5.0 pA/pF (PG, n = 20 cells) vs. 53.9 +/- 5.0 pA/pF (EG, n = 24)], I(sus) [11.3 +/- 1.4 pA/pF (PG, n = 20) vs. 10.2 +/- 1.0 pA/pF (EG, n = 24)], and I(K1) [-1.6 +/- 0.3 pA/pF (PG, n = 17) vs. -2.0 +/- 0.3 pA/pF (EG, n = 22)]. However, alcohol infusion resulted in a remarkable reduction of I(Ca,L) current densities [-28.4 +/- 1.8 pA/pF (PG, n = 20) vs. -15.2 +/- 1.4 pA/pF (EG, n = 22)] and I(Na) [-75.4 +/- 3.6 pA/pF (PG, n = 17) vs. -35.4 +/- 4.4 pA/pF (EG, n = 21)], respectively. CONCLUSION: Sustained short-term ethanol infusion in rabbits alters atrial current densities. HHS might be favored by alcohol-induced atrial electrical remodeling. SN - 1530-0277 UR - https://www.unboundmedicine.com/medline/citation/19572985/Alcohol_induced_electrical_remodeling:_effects_of_sustained_short_term_ethanol_infusion_on_ion_currents_in_rabbit_atrium_ L2 - https://doi.org/10.1111/j.1530-0277.2009.01006.x DB - PRIME DP - Unbound Medicine ER -